Cardiovascular Syphilis (Syphilitic Aortitis)

Cardiovascular manifestations of SYPHILIS, an infection of TREPONEMA PALLIDUM. In the late stage of syphilis, sometimes 20-30 years after the initial infection, damages are often seen in the blood vessels including the AORTA and the AORTIC VALVE. Clinical signs include syphilitic aortitis, aortic insufficiency, or aortic ANEURYSM.

Also Known As:

Networked: 81 relevant articles (3 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	tertiary Syphilis
2.	Pathologic Constriction (Stenosis)
3.	Aortic Valve Insufficiency (Aortic Regurgitation)
4.	Syphilis
5.	Neurosyphilis (General Paresis of the Insane)

Experts

1.	Guo, Yingqiang: 1 article (04/2022)
2.	Kang, Zhefeng: 1 article (04/2022)
3.	Liu, Lulu: 1 article (04/2022)
4.	Peng, Ying: 1 article (04/2022)
5.	Xiao, Bowen: 1 article (04/2022)
6.	Chen, Hong: 1 article (12/2021)
7.	Lin, Li-Rong: 1 article (12/2021)
8.	Lin, Yong: 1 article (12/2021)
9.	Shen, Xu: 1 article (12/2021)
10.	Zheng, Ya-Wen: 1 article (12/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cardiovascular Syphilis:

1.	Penicillins (Penicillin)FDA Link 11/03/1951 - "Treatment of cardiovascular syphilis; efficacy of penicillin: studies based on Ill cases." 11/01/2015 - "Cardiovascular syphilis is a rare entity since the discovery of penicillin. " 06/01/1961 - "[Syphilitic aortitis with penicillin]." 03/01/1956 - "[Cardiovascular syphilis; treatment by penicillin]." 01/01/1955 - "The penicillin treatment of cardiovascular syphilis."
2.	Anti-Bacterial Agents (Antibiotics)IBA 07/01/2017 - "We present a rare case of syphilitic aortitis in a era of highly effective antibiotics. " 12/01/2003 - "Today, however, cardiovascular syphilis is a medical curiosity because the disease can successfully be treated with antibiotics in its early phase. " 12/01/2009 - "If the findings are positive or if characteristic morphologic features of cardiovascular syphilis are suspected, irrespective of the results of the serologic tests, antibiotic therapy appears desirable." 12/01/1983 - "Syphilitic aortitis can be treated successfully if an accurate diagnosis is made early and if appropriate antibiotic therapy is instituted. " 03/25/2023 - "A syphilitic aortitis is a late cardiovascular lesion of tertiary syphilis that has become exceptionally rare in the antibiotic era but not eradicated completely. "
3.	IodineIBA 12/10/1949 - "[On the efficacy of iodine and its compounds in cardiovascular syphilis]." 01/01/2000 - "Highly iodinated oil such as lipiodol from Lafay discovered in 1901 were part of expanding the therapeutic use of iodine for various pathologies such as syphilis, cardiovascular and respiratory diseases, leprosy, goiter... "
4.	MercuryIBA 10/14/1949 - "Treatment of syphilitic aortitis with mercury cyanide in very prolonged cures." 03/01/1946 - "Extended cures of mercury cyanide in the treatment of syphilitic aortitis."
5.	Lipoproteins (Lipoprotein)IBA 04/01/1964 - "[LIPOPROTEINS AND FREE CHOLESTEROL IN PATIENTS WITH SYPHILITIC AORTITIS]." 08/01/1962 - "[Protein composition and lipoproteins in the blood serum in patients with syphilitic aortitis]."
6.	Cyanides (Isocyanides)IBA 10/14/1949 - "Treatment of syphilitic aortitis with mercury cyanide in very prolonged cures." 03/01/1946 - "Extended cures of mercury cyanide in the treatment of syphilitic aortitis."
7.	CholesterolIBA 01/01/1955 - "[Cholesterol blood level in syphilitic aortitis]." 04/01/1964 - "[LIPOPROTEINS AND FREE CHOLESTEROL IN PATIENTS WITH SYPHILITIC AORTITIS]."
8.	Therapeutic UsesIBA 01/01/2000 - "Highly iodinated oil such as lipiodol from Lafay discovered in 1901 were part of expanding the therapeutic use of iodine for various pathologies such as syphilis, cardiovascular and respiratory diseases, leprosy, goiter... "
9.	ReaginsIBA 06/01/2011 - "We report a case of syphilitic aortitis complicated by multiple aortic aneurysms in a 50-year-old man with elevated rapid plasma reagin titer of 1:128 and positive Treponema pallidum particle agglutination test. "
10.	Proteins (Proteins, Gene)FDA Link 08/01/1962 - "[Protein composition and lipoproteins in the blood serum in patients with syphilitic aortitis]."

Therapies and Procedures

1.	Therapeutics 10/01/2006 - "This paper reviews the natural history, diagnosis and therapy of cardiovascular syphilis." 12/24/1956 - "[Cardiovascular syphilis and its therapy]." 11/20/1953 - "[Present state of therapy of cardiovascular syphilis]." 08/01/1953 - "[Therapy of cardiovascular syphilis]." 12/01/1952 - "[The recent therapy of cardiovascular syphilis]."
2.	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 10/01/2023 - "Treatment of syphilitic aortitis with coronary artery bypass grafting and "open" stent placement." 04/01/2022 - "Cardiovascular syphilis presented with concomitant aortic regurgitation (AR) and left coronary ostial stenosis is rare, usually treated with on-pump aortic valve replacement and coronary artery bypass graft. " 07/01/2014 - "We report here a case in which bilateral coronary ostial stenosis and aortic regurgitation due to syphilitic aortitis was diagnosed; coronary artery bypass graft was then performed. " 01/01/1998 - "We report here a case in which bilateral coronary ostial stenosis and aortic regurgitation due to syphilitic aortitis was diagnosed; coronary artery bypass graft and aortic valve replacement were then performed. "
3.	Percutaneous Coronary Intervention 04/01/2022 - "We report a critical case of AR and left coronary ostial stenosis due to cardiovascular syphilis treated with emergent salvage transcatheter aortic valve replacement and percutaneous coronary intervention." 09/01/2013 - "Bilateral coronary ostial stenosis with bilateral renal ostial stenosis in cardiovascular syphilis: de novo percutaneous coronary intervention and in-stent restenosis." 09/22/2023 - "Tertiary Cardiovascular Syphilis Presenting as Aortic Regurgitation, Aortitis, Thrombus, and Coronary Artery Occlusion, Requiring Percutaneous Coronary Intervention."
4.	Stents 10/01/2023 - "Treatment of syphilitic aortitis with coronary artery bypass grafting and "open" stent placement." 09/01/2013 - "Bilateral coronary ostial stenosis with bilateral renal ostial stenosis in cardiovascular syphilis: de novo percutaneous coronary intervention and in-stent restenosis."
5.	Transcatheter Aortic Valve Replacement 04/01/2022 - "Cardiovascular syphilis treated with transcatheter aortic valve replacement." 04/01/2022 - "We report a critical case of AR and left coronary ostial stenosis due to cardiovascular syphilis treated with emergent salvage transcatheter aortic valve replacement and percutaneous coronary intervention."