|2.||HIV Infections (HIV Infection)
|3.||Congenital Syphilis (Hutchinson's Teeth)
|1.||Klausner, Jeffrey D: 20 articles (02/2015 - 08/2003)|
|2.||Lukehart, Sheila A: 14 articles (06/2015 - 07/2002)|
|3.||Chen, Xiang-Sheng: 14 articles (03/2013 - 05/2006)|
|4.||Hung, Chien-Ching: 12 articles (05/2015 - 10/2010)|
|5.||Tucker, Joseph D: 12 articles (02/2015 - 08/2007)|
|6.||Jia, Yujiang: 12 articles (01/2015 - 02/2009)|
|7.||Ghanem, Khalil G: 11 articles (12/2015 - 03/2006)|
|8.||Strathdee, Steffanie A: 10 articles (01/2015 - 01/2006)|
|9.||Mabey, David: 9 articles (06/2015 - 10/2002)|
|10.||Yin, Yue-Ping: 9 articles (03/2013 - 05/2006)|
|1.||Penicillins (Penicillin)FDA Link
12/01/2013 - "Penicillin is highly effective against syphilis and remains the treatment of choice. "
07/01/1993 - "Although penicillin still remains highly effective for syphilis, concerns have been raised that current regimens may be inadequate for the treatment of early syphilis. "
08/01/1980 - "Although penicillin remains highly effective in syphilis, important questions exist regarding the optimal regimen for syphilitic involvement of the nervous system. "
04/15/2000 - "Although the efficacy of penicillin treatment for syphilis has been amply demonstrated, the optimal, curative dosage is still undefined. "
06/01/1990 - "Despite availability of simpler serologic tests for syphilis and near cure with penicillin, unacceptably high prevalence of infectious maternal syphilis exist in many developing countries, including Zambia. "
|2.||Azithromycin (Zithromax)FDA LinkGeneric
06/01/2000 - "This study demonstrates that azithromycin is effective in the treatment of early syphilis. "
01/28/2012 - "Oral azithromycin is effective for syphilis. "
08/01/2002 - "Preliminary data suggest that azithromycin may be effective for syphilis therapy. "
09/01/1994 - "Azithromycin has in vitro activity against Treponema pallidum and is effective against experimental syphilis in rabbits. "
06/01/2000 - "An open, noncomparative study was performed to establish the efficacy of azithromycin in the treatment of early syphilis. "
|3.||Penicillin G Benzathine (LPG)FDA Link
07/15/2015 - "Intramuscular benzathine penicillin G (BPG) is widely used for the treatment of syphilis. "
02/15/2015 - "A single dose of benzathine penicillin G is as effective as multiple doses of benzathine penicillin G for the treatment of HIV-infected persons with early syphilis."
06/11/1976 - "The results of the study confirm the efficacy of one-shot treatment of the syphilis by administration of 2,400,000 to units of benzathine penicillin."
01/01/2002 - "This may be with respect to efficacy, for example in syphilis with single-dose benzathine penicillin therapy, particularly for pregnant women and individuals infected with HI. "
01/01/2012 - "Further studies on the utility of benzathine penicillin G for early syphilis are warranted."
11/01/1960 - "New and improved antigen suspension for rapid reagin tests for syphilis."
10/01/1986 - "pallidum, this antigen might be useful for development of a vaccine against syphilis and for development of improved methods for serodiagnosis of syphilis."
06/26/2007 - "Abbott Determine Syphilis TP test (ELISA based on the recombinant Tp antigen), RPR test, and Treponema pallidum haemagglutination assay (TPHA) were conducted with TPHA used as the gold standard. "
10/01/2011 - "This study demonstrates system performance by delivering antibody (Ab) reactivity results simultaneously for multiple antigens of HIV-1, Treponema pallidum (syphilis), and hepatitis C virus (HCV) in a collection of clinical serum, plasma, and whole-blood samples. "
02/01/2009 - "In the presented study a particle gel immunoassay (ID-PaGIA syphilis antibody test, Diamed) using recombinant treponemal antigens TpN15, TpN17 and TpN47 was evaluated as a screening test in comparison to the currently used Treponema pallidum particle agglutination test (Serodia-TPPA, Fujirebio). "
06/13/1980 - "Syphilis antibodies were demonstrated in the blood of 48 children, these positive results being confirmed by further tests. "
03/01/2013 - "A dual point-of-care test shows good performance in simultaneously detecting nontreponemal and treponemal antibodies in patients with syphilis: a multisite evaluation study in China."
06/01/2012 - "In the present study, the performance of the Determine Syphilis TP assay (Determine TP assay) for the detection of antibodies against Treponema pallidum (T. "
05/01/2008 - "pallidum were investigated based on previous screening studies indicating that anti-TP0136 antibodies are present in the sera of syphilis patients and experimentally infected rabbits. "
04/01/2008 - "The purpose of the present study was to analyze the profile of anti-Tp47 antibodies in patients with positive serology for syphilis. "
|6.||Ceftriaxone (Ceftriaxon)FDA LinkGeneric
04/01/2007 - "Ceftriaxone is effective for the treatment of syphilis when used in multiple-dose regimens. "
08/01/2005 - "To evaluate the efficacy of ceftriaxone in pregnant women who were diagnosed with early syphilis. "
01/01/1987 - "Thus, it seems justified to start clinical trials on the definite role of ceftriaxone in the treatment of clinical syphilis."
02/24/2011 - "Ceftriaxone is commonly used as an alternative antibiotic drug in treating syphilis but clinical data on its efficacy are limited. "
08/01/2005 - "Ceftriaxone may be considered as an alternative for treatment of early syphilis in pregnancy."
01/01/2011 - "As low s/co levels detected with CMIA may lead to false-positive results for syphilis, it was concluded that CMIA positive results should be confirmed by another treponemal test before RPR testing. "
12/01/2015 - "This study will reveal the clinical and laboratory characteristics in the group of individuals co-infected with ocular syphilis and HIV compared with HIV-negative individuals. "
01/01/2015 - "VITROS(®) syphilis TPA showed 100% sensitivity and specificity with precision (20 days study) of <10% co-efficient of variation. "
01/01/2011 - "In this study, a testing algorithm using treponemal chemiluminescence microparticle enzyme immunoassay (CMIA; Architect Syphilis TP; Abbott Japan Co, Japan) for primary screening were retrospectively evaluated by reviewing laboratory data. "
10/01/2015 - "Seronegative syphilis in a patient co-infected with HIV."
04/01/1979 - "Associated with the cardiolipin test it may be preferably used for the detection of syphilis, and moreover, passive haemagglutination may confirm the diagnosis in case of weak positive results with the FTA--ABS test. "
04/01/1978 - "Studies were carried out on the comparative value of passive haemaglutination, cardiolipin and treponema tests in a total number of 4327 sera syphilitic patients in various stages of the disease and apparently normal subjects or free of syphilis. "
01/01/1953 - "[On the use of serological micromethods in the study of syphilis; the cardiolipin microtest and a modified Meinicke micromethod]."
11/01/1992 - "Enhancement of cardiolipin binding activity by beta 2GP1 was observed for APS, but not for syphilis. "
09/01/1992 - "Cardiolipin antibody (VDRL) was positive but specific tests for syphilis were negative. "
|9.||Anti-Bacterial Agents (Antibiotics)IBA
06/01/1982 - "Both antibiotics were very effective in the treatment of syphilis in this animal model. "
02/01/2001 - "Improved hygiene and wide use of antibiotics that minimize or abolish symptoms of early disease may have contributed to the frequency of syphilis incognito in recent years. "
06/01/1977 - "As a result of the almost universal ingestion of antibiotics for trivial conditions, many cases of syphilis will be modified or arrested and some patients will be cured of the disease without ever knowing that they have acquired it. "
06/01/1984 - "The aim of our study is to evaluate the activity of antibiotics on Treponema pallidum (Tp) in the early stage of syphilis. "
01/01/1969 - "[Experimental studies on the treatment of syphilis with various antibiotics]."
03/01/1991 - "The Wassermann test was "invented" for serologic diagnosis, and Paul Ehrlich proved that salvarsan, or 606, was effective for the treatment of syphilis. "
10/01/2010 - "The year 2009 marks the centenary of the discovery of the experimental anti-syphilitic activity of Salvarsan and the first clinical studies showing its efficacy against syphilis. "
06/30/1925 - "STUDIES IN EXPERIMENTAL SYPHILIS : III. FURTHER OBSERVATIONS ON THE POSSIBILITY OF CURE OF SYPHILIS IN THE RABBIT WITH ARSPHENAMINE."
06/01/2014 - "The treatment of syphilis with salvarsan."
01/01/2014 - "The first drug, Salvarsan, was developed by Ehrlich using rabbits infected with the organism causing syphilis. "
|1.||Male Circumcision (Circumcision)
04/01/2003 - "It is suggested that the original statistics were of dubious value and that the promise of protection against syphilis was an additional argument for doctors who were keen to introduce universal circumcision of male infants for other reasons, the most significant of which was related to the conviction that it would discourage masturbation. "
11/01/2014 - "Male circumcision was associated with a 42% reduction in incident syphilis in men (adjusted hazard ratio [aHR] 0·58, 95% CI 0·37-0·91) including a 62% reduction in men with HIV (0·38, 0·18-0·81), and a non-significant reduction in incident syphilis in men without HIV (0·64, 0·36-1·11). "
01/01/2007 - "Male circumcision may have been modestly protective against syphilis in HIV-uninfected heterosexual men (PR 0.92, 95% C.I. 0.83-1.02, P = 0.06). "
04/01/2003 - ""Where doctors differ": the debate on circumcision as a protection against syphilis, 1855-1914."
01/01/2011 - "There was no significant association between male circumcision and syphilis (8 studies; 34,999 participants: OR 0.96, 95% CI 0.82 to 1.13; I² = 0%), herpes simplex virus 1 (2 studies, 2740 participants; OR 0.90, 95% CI 0.53 to 1.52; I²=0%), or herpes simplex virus 2 (5 studies;10,285 participants; OR 0.86, 95% CI 0.62 to 1.21; I²=0%). "
01/01/2011 - "The Avahan program in Tamil Nadu achieved high coverage of FSWs, resulting in outcomes of improved condom use, declining syphilis and stabilizing HIV prevalence. "
04/01/2004 - "Targeted community based small media interventions using community partners for distribution are effective in increasing syphilis knowledge, testing, and condom use."
12/01/1991 - "The condom was first mentioned in a 1564 writing by Gabriel Fallopius as a means of protection against syphilis describing his tests on 1100 people. "
12/01/2010 - "In this study, inconsistent use of condoms and a greater number of sexual partners were risk factors for syphilis in MSM. "
11/01/2010 - "The purpose of this study is to assess prevalence and correlates of syphilis and condom use with female sex workers (FSWs) among male IDUs in Hirat, Jalalabad, Kabul, and Mazar-i-Sharif, Afghanistan. "
05/01/2012 - "The aim of the present study is to describe angiographic patterns encountered in the context of ocular syphilis, and to explore the associations between specific angiographic manifestations and severity of disease presentation, as well as disease evolution after treatment. "
11/01/2011 - "The aim of this study is to determine whether statistical associations can be demonstrated in ocular syphilis between baseline clinical and laboratory parameters with visual acuity at presentation and with any change in visual acuity after treatment. "
10/01/1980 - "The quantitative MHA-TP in humans after treatment for syphilis and reinfection deserves further study."
02/01/2015 - "Potential Predictors for Serofast State after Treatment among HIV-Negative Persons with Syphilis in China: A Systematic Review and Meta-Analysis."
05/01/2014 - "However, there were no significant differences when we compared the positive rate of syphilis patients before and after treatment by TPPA, TP-ELISA, and TP-CMIA. "
03/01/2013 - "Attending a prenatal care program was protective against syphilis (p=0.008) and HIV-1 (p=0.02). "
12/01/2014 - "The objective of this study was to identify possible barriers to control vertical transmission of syphilis and HIV through the analysis of the orientation process of pregnant women from prenatal care to the obstetric center at an university hospital in Sao Paulo (Reference) and their return (with their exposed babies) for follow-up after hospital discharge (counter-reference). "
03/01/2014 - "The population of the present study mostly consisted of adult black women with low educational levels who attended prenatal care, who were diagnosed with syphilis during pregnancy, and whose partners were not treated for syphilis. "
06/01/2007 - "We studied predictors of no prenatal care (PNC) and influence of no PNC on pregnancy outcome in a multisite study of 1071 women with syphilis in Russia. "
11/01/2006 - "This study was designed to evaluate the extent to which pregnant women in a community with a high syphilis incidence were screened for syphilis according to standard recommendations of twice during prenatal care and at labor and delivery. "
01/01/2009 - "Health officials were especially concerned that prostitutes (and other women of "loose morals") would not comply with the traditional lengthy and arduous treatment for syphilis, which involved weekly injections of arsenical drugs for a year or more and unpleasant side effects. "
08/01/1995 - "Associations were observed with marital status, injections, education, travel, history of STD and syphilis serology. "
01/01/1994 - "Patients with secondary recurrent syphilis whose body mass exceeded 85 kg (55 cases) and subjects with latent disease (72 cases) received 3 injections in 7-day intervals. "
01/01/1994 - "Two injections with 7-day interval were carried out in the dose 2400000 U for primary seropositive (58 cases), secondary early (14 cases) and recurrent syphilis (36 cases). "
01/16/1943 - "Daily Multiple Injections of Mapharside for Syphilis."