Syphilis

12/01/2013 - "Penicillin is highly effective against syphilis and remains the treatment of choice. "
07/01/1993 - "Although penicillin still remains highly effective for syphilis, concerns have been raised that current regimens may be inadequate for the treatment of early syphilis. "
08/01/1980 - "Although penicillin remains highly effective in syphilis, important questions exist regarding the optimal regimen for syphilitic involvement of the nervous system. "
04/15/2000 - "Although the efficacy of penicillin treatment for syphilis has been amply demonstrated, the optimal, curative dosage is still undefined. "
12/01/1998 - "Early treatment can result in a good outcome and stem the spread of the disease; as with other forms of syphilis, penicillin is the drug of choice."

04/01/2017 - "Through the important women who lived their lives fighting against this disease and its complications, we would like to pay tribute to all those women who still today, in an era of antibiotics and where syphilis is a treatable pathology, they cannot be cured because they are both geographically and socially disadvantaged."
06/01/1982 - "Both antibiotics were very effective in the treatment of syphilis in this animal model. "
07/01/2020 - "On subsequent serological testing it was proved as syphilis in a HIV-positive patient who responded well to intravenous antibiotics with rapid visual recovery. "
12/01/2023 - "We assessed the in-vitro efficacy of 18 antibiotics from several classes on Treponema pallidum subspecies pallidum (T pallidum), the syphilis bacteria. "
04/01/2014 - "With proper diagnosis and prompt antibiotic treatment, the majority of cases of ocular syphilis can be cured. "

01/01/2016 - "The diagnosis of endemic syphilis was based on the absence of factor in favor of venereal syphilis, highly positive results suggesting VDRL/TPHA association, histology of velar perforation banks and the satisfactory response with closure of the perforation velar after 4 weeks of treatment with Benzathine benzylpenicillin. "
09/01/2022 - "A single dose of benzathine penicillin G as an effective treatment for malignant syphilis in an HIV-positive patient: a case report."
02/04/2016 - "To assess the efficacy of three doses versus a single dose of long acting Benzathine Penicillin G (BP-G) for the effective management of early syphilis among HIV co-infected populations. "
07/15/2015 - "Intramuscular benzathine penicillin G (BPG) is widely used for the treatment of syphilis. "
02/15/2015 - "A single dose of benzathine penicillin G is as effective as multiple doses of benzathine penicillin G for the treatment of HIV-infected persons with early syphilis."

05/01/2008 - "The aim of this study was to detect the sensitivity and specificity of rapid syphilis diagnostic tests (immunochromatographic strip [ICS] test and rapid test device [RTD]) performed by low-skilled paramedics in field clinics and by highly-skilled technologists in laboratories and compare them with the gold standard (rapid plasma reagin [RPR] and Treponema pallidum haemagglutination [TPHA]) tests for diagnosis of syphilis. "
12/01/2006 - "A study found screening (with rapid plasma reagin (RPR)) pregnant women for maternal syphilis was cost-effective in Mwanza, Tanzania. "
01/01/2023 - "Rapid plasma reagin (RPR) test of serum showed positive results for syphilis. "
01/01/2019 - "The treponemal syphilis component of the dual rapid test was compared with the Treponema pallidum hemagglutination assay (TPHA) as a gold standard comparator, both alone or in combination with a nontreponemal test, the rapid plasma reagin test. "
01/01/2018 - "The analytical performance of the AIX1000 system, a fully automated and recently FDA-cleared rapid plasma reagin (RPR) system, was evaluated by comparison to a manual RPR test in a traditional syphilis testing algorithm. "

06/01/2000 - "This study demonstrates that azithromycin is effective in the treatment of early syphilis. "
01/28/2012 - "Oral azithromycin is effective for syphilis. "
09/01/1994 - "Azithromycin has in vitro activity against Treponema pallidum and is effective against experimental syphilis in rabbits. "
06/01/2000 - "An open, noncomparative study was performed to establish the efficacy of azithromycin in the treatment of early syphilis. "
12/01/2011 - "Although additional data on the efficacy of azithromycin in treating early syphilis have emerged, reported increases in the prevalence of a mutation associated with azithromycin resistance precludes a recommendation for its routine use. "

01/01/2020 - "We reviewed relevant syphilis diagnostic literature and conducted a meta-analysis to address the question, "What is the sensitivity and specificity of the Syphilis Health Check, a rapid qualitative test for the detection of human antibodies to Treponema pallidum." The Syphilis Health Check is the only rapid syphilis test currently cleared by the Food and Drug Administration (FDA). "
08/16/2019 - "The resultant sensor is able to detect antibodies against Treponema pallidum pallidum, the causative agent of syphilis, at clinically relevant concentrations in samples in less than 10 min. Preliminary results obtained using sero-positive and sero-negative human samples suggest the clinical sensitivity and specificity of the approach compare well to current gold-standard tests, while being simple and rapid enough to deploy at the point of care."
06/13/1980 - "Syphilis antibodies were demonstrated in the blood of 48 children, these positive results being confirmed by further tests. "
01/01/2022 - "Point-of-care dual tests (POCTs) for simultaneously detecting antibodies to HIV and syphilis (dual HIV-syphilis POCTs) have been developed recently and show encouraging performance compared with the reference tests in laboratory-based studies. "
06/01/2020 - "Our study showed that high titers of anti-TP0136 antibodies promoted the infiltration of inflammatory cells into local lesions and intensified tissue damage, thus delaying wound healing, and had no protective effect on the occurrence of syphilis in the rabbit model."

08/19/2022 - "The serum and cerebrospinal fluid serological and antigen tests for syphilis had positive results. "
06/26/2007 - "Abbott Determine Syphilis TP test (ELISA based on the recombinant Tp antigen), RPR test, and Treponema pallidum haemagglutination assay (TPHA) were conducted with TPHA used as the gold standard. "
01/01/2019 - "The objective of this study was to screen new antigens for syphilis serodiagnosis. "
11/01/2017 - "Tp0693 may be used as a diagnostic antigen for syphilis; however, further study regarding its potential use is required."
11/01/2017 - "The aim of the present study was to evaluate the diagnostic value of the Treponema pallidum (Tp) antigen Tp0693 for syphilis. "

01/01/2015 - "The desire for safe and effective vaccine of syphilis requests identification of important steps in T. "
10/12/2017 - "More investment is needed in research on the interaction between HIV and syphilis in MSM as well as into improved diagnostics, a better test of cure, intensified public health measures and, ultimately, a vaccine."
01/01/2023 - "In spite of these promising results, there is still some controversy regarding the identification of vaccine candidates and the characteristics of a syphilis-protective immune response. "
07/01/2011 - "In the prevention of syphilis, a potential vaccine protective against syphilis should be designed to augment the DTH response."
07/24/2023 - "Additional analyses to explore TPA OMP variability within strains will be vital for vaccine development and improved understanding of syphilis pathogenesis on a population level. "

07/01/2017 - "Doxycycline is still an effective agent for the treatment of early syphilis."
03/15/2006 - "Doxycycline appears to be an effective agent for the treatment of early syphilis."
01/01/2017 - "Efficacy of Doxycycline in the Treatment of Syphilis."
11/01/2023 - "A number of randomized controlled trials have found that doxycycline post exposure prophylaxis (PEP) can reduce the incidence of gonorrhoea, chlamydia and syphilis in men who have sex with men (MSM). "
01/01/2023 - "Four randomized controlled trials have now established that doxycycline post exposure (sex) prophylaxis (PEP) can reduce the incidence of chlamydia and syphilis in men who have sex with men. "

04/01/2007 - "Ceftriaxone is effective for the treatment of syphilis when used in multiple-dose regimens. "
10/23/2023 - "The aim of this study was to investigate the safety and efficacy of ceftriaxone as an alternative treatment option for syphilis during pregnancy. "
08/01/2005 - "To evaluate the efficacy of ceftriaxone in pregnant women who were diagnosed with early syphilis. "
08/15/2023 - "This study showed that almost all of the 15 patients were well treated for ocular syphilis with Ceftriaxone without any signs of therapeutic failure with documented clinical improvement and satisfactory decreasing VDRL titers."
10/30/2017 - "In this study, ceftriaxone regimen was noninferior to the BPG regimen in nonpregnant, immunocompetent patients with early syphilis. "

12/18/1998 - "The findings of this investigation indicate that the clinic closure resulted in a marked decrease in reported syphilis in the NW ward, and suggest that NW ward residents with syphilis and their partners may not have received proper diagnostic testing, therapy, and counseling."
12/01/1988 - "Examination of the CSF may be beneficial in patients with early syphilis, and therapy should be guided by knowledge of central nervous system involvement. "
02/01/1997 - "Improved laboratory services and better education of local providers and surveillance workers will solve some problems in the diagnosis and therapy of syphilis during pregnancy. "
04/01/1995 - "Conventional therapy for syphilis may not be effective in patients with HIV. "
01/01/2004 - "Except for irreversible tissue destruction which occurs prior to therapy, all stages of syphilis can be cured completely."

01/16/2018 - "Eliminating MTCT of syphilis through screening and treatment in antenatal care (ANC) is highly cost-effective in a wide range of settings, especially in countries with a high prevalence."
01/01/2016 - "Improved access to quality antenatal care, including syphilis testing and treatment, and robust data are all important for achieving the elimination of mother-to-child transmission of syphilis. "
06/01/2000 - "More active training of nurse midwives in antenatal care to perform on site RPR tests, to give syphilis treatment, and to notify partners results in improved perinatal outcome and more seronegative parturient women."
03/01/2013 - "Attending a prenatal care program was protective against syphilis (p=0.008) and HIV-1 (p=0.02). "
01/01/2020 - "In Duguna Fango, the verification factor for number of pregnant women that received their first antenatal care visit improved from 0.794 (95%CI 0.753, 0.836; p<0.001) pre-intervention by 0.173 (95%CI 0.128, 0.219; p<0.001) during the collaborative; and the verification factor for number of pregnant women tested for syphilis improved from 0.472 (95%CI 0.390, 0.554; p<0.001) pre-intervention by 0.460 (95%CI 0.369, 0.552; p<0.001) during the collaborative. "

12/29/2011 - "The Avahan program in Tamil Nadu achieved high coverage of FSWs, resulting in outcomes of improved condom use, declining syphilis and stabilizing HIV prevalence. "
01/01/2019 - "Our study results suggest that among YBMSM in Chicago, interventions promoting condom use may be less effective for syphilis prevention compared to HIV prevention in this population. "
04/01/2004 - "Targeted community based small media interventions using community partners for distribution are effective in increasing syphilis knowledge, testing, and condom use."
12/01/1991 - "The condom was first mentioned in a 1564 writing by Gabriel Fallopius as a means of protection against syphilis describing his tests on 1100 people. "
06/10/2022 - "Conclusion: Compared with routine VCT, social media based behavioral intervention might promote joint HIV and syphilis testing in the young MSM who used condom in the study. "

05/01/2019 - "Findings improved after treatment for syphilis. "
01/01/2021 - "Conclusions: Few patients with syphilis tested negative after treatment at the end of the study. "
01/01/2021 - "The aim of this study was to explore the factors associated with serological cure after treatment of early syphilis. "
05/01/2012 - "The aim of the present study is to describe angiographic patterns encountered in the context of ocular syphilis, and to explore the associations between specific angiographic manifestations and severity of disease presentation, as well as disease evolution after treatment. "
11/01/2011 - "The aim of this study is to determine whether statistical associations can be demonstrated in ocular syphilis between baseline clinical and laboratory parameters with visual acuity at presentation and with any change in visual acuity after treatment. "

11/01/2014 - "Male circumcision was associated with a 42% reduction in incident syphilis in men (adjusted hazard ratio [aHR] 0·58, 95% CI 0·37-0·91) including a 62% reduction in men with HIV (0·38, 0·18-0·81), and a non-significant reduction in incident syphilis in men without HIV (0·64, 0·36-1·11). "
09/12/2007 - "Male circumcision may have been modestly protective against syphilis in HIV-uninfected heterosexual men (PR 0.92, 95% C.I. 0.83-1.02, P = 0.06). "
06/15/2011 - "There was no significant association between male circumcision and syphilis (8 studies; 34,999 participants: OR 0.96, 95% CI 0.82 to 1.13; I² = 0%), herpes simplex virus 1 (2 studies, 2740 participants; OR 0.90, 95% CI 0.53 to 1.52; I²=0%), or herpes simplex virus 2 (5 studies;10,285 participants; OR 0.86, 95% CI 0.62 to 1.21; I²=0%). "
09/12/2007 - "The study objective was to describe male circumcision trends among men attending the San Francisco municipal STD clinic, and to correlate the findings with HIV, syphilis and sexual orientation. "
12/01/2019 - "Male circumcision and the risk of gonorrhoea, syphilis, HIV and human papillomavirus among men in Tanzania."