Pigmented Villonodular Synovitis

Subscribe to Selected New Research on Pigmented Villonodular Synovitis

80 relevant articles (3 outcomes, 2 trials/studies) found for this Disease

Description: Outgrowths of synovial membrane composed of villi and fibrous nodules characterized histologically by hemosiderin- and lipid-containing macrophages and multinucleated giant cells. It usually occurs in the knee.

Also Known As:

Synovitis, Pigmented Villonodular; Pigmented Villonodular Synovitides; Synovitides, Pigmented Villonodular; Villonodular Synovitides, Pigmented; Villonodular Synovitis, Pigmented

Relationship Network

Disease Context: Research Results

Musculoskeletal Diseases: 87

Joint Diseases: 1574

Synovitis: 1789

Pigmented Villonodular Synovitis: 80

Related Diseases

1.	Giant Cell Tumors (Giant Cell Tumor)
2.	Synovitis
3.	Osteoarthritis
4.	Rheumatoid Arthritis
5.	Arthritis (Polyarthritis)

Experts

1.	Finis, Katharina: 2 articles (10/2007 - 03/2006)
2.	Poustka, Annemarie: 2 articles (10/2007 - 03/2006)
3.	Gross, Marie-Luise: 2 articles (10/2007 - 03/2006)
4.	Berger, Irina: 2 articles (10/2007 - 03/2006)
5.	Lui, Tun Hing: 1 article (08/2008)
6.	Bulut, Okay: 1 article (08/2008)
7.	Oztemur, Zekeriya: 1 article (08/2008)
8.	Ozturk, Hayati: 1 article (08/2008)
9.	Stephen, Lau Wai Yip: 1 article (08/2008)
10.	Bulut, Sema: 1 article (08/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pigmented Villonodular Synovitis:

1.	HemosiderinIBA 09/01/2009 - "Microscopic examination of a specimen procured using fine-needle biopsy revealed multinucleated giant cells, hemosiderin deposition, and foaming histiocytes, indicative of pigmented villonodular synovitis. " 10/01/2007 - "Pigmented villonodular synovitis (PVNS) is a benign but potentially aggressive lesion, characterized by synovial villonodular proliferation with hemosiderin pigmentation and stromal infiltration of histiocytes and giant cells. " 01/01/1998 - "BACKGROUND: Pigmented villonodular synovitis (PVNS) is characterized by hypervascular proliferative synovium containing multinucleated giant cells, macrophages, and hemosiderin. " 11/01/1997 - "CONCLUSION: The cytologic features of pigmented villonodular synovitis in synovial fluid include abundant mononuclear histiocytic cells occurring singly and in papillary clusters, hemosiderin within histiocytes and few multinucleated giant cells." 02/01/1997 - "Pigmented villonodular synovitis is a condition characterized by cell proliferation and deposition of hemosiderin into the lining tissues of joints, tendons, and bursae. " Order ALL the reference details at left...
2.	YttriumIBA 02/01/1987 - "Yttrium 90 synovectomy--a new treatment for pigmented villonodular synovitis." 08/01/2008 - "Pigmented villonodular synovitis managed by Yttrium 90 after debulking surgery." 02/01/2008 - "CONCLUSIONS: Because of the unacceptably high rate of serious complications associated with the injection of yttrium 90 into the ankle joint following subtotal synovectomy, we discontinued its use as a local adjuvant in the management of diffuse pigmented villonodular synovitis of the ankle." 02/01/2008 - "Our initial and highly satisfactory experience with the injection of radioactive yttrium 90 to treat pigmented villonodular synovitis of the ankle joint eroded with time so much so that we discontinued its use in the ankle and believe that it is important to alert our colleagues to the complications that we observed. " 10/01/2002 - "The use of surgery and yttrium 90 in the management of extensive and diffuse pigmented villonodular synovitis of large joints." Order ALL the reference details at left...
3.	IronIBA 01/01/1998 - "[Iron deposits, cell populations and proliferative activity in pigmented villonodular synovitis of the knee joint]" 11/01/1979 - "Pigmented villonodular synovitis is a rare lesion in which iron is accumulated. " 11/01/1979 - "Iron content of pigmented villonodular synovitis detected by computed tomography." 03/01/2004 - "Iron pigment deposition and inflammation are mild to absent, making synovial excrescences different from pigmented villonodular synovitis. " 01/01/1986 - "A detailed ultrastructural study was made of the synovial iron deposits in cases of haemophilic synovitis (HS), pigmented villonodular synovitis (PVNS), rheumatoid arthritis (RA), osteoarthritis (OA), seronegative inflammatory arthritis (SNA), and in controls, to investigate the relationship between iron deposits and tissue damage. " Order ALL the reference details at left...
4.	ParaffinIBA 11/01/2001 - "Osteoarthritis (OA) and pigmented villonodular synovitis (PVNS) are disorders associated with trisomy 7. The aim of the present study was to determine the frequency and distribution of the cells with +7 in vivo by analyzing sections of paraffin-embedded synovia from patients affected by OA, PVNS, other forms of synovitis [hemorragic synovitis (HS) and chronic synovitis (CS)], and from individuals without joint disease. " 04/01/2008 - "Immunohistochemistry was used to evaluate p63 expression in paraffin embedded sections of giant cell tumor of bone and in tumors containing multinucleated giant cells, including: giant cell tumor of tendon sheath, pigmented villonodular synovitis, aneurysmal bone cyst, chondroblastoma, and central giant cell granuloma. " 12/01/2004 - "Using a monoclonal antibody with a standard immunohistochemical technique on paraffin sections, we evaluated expression of Mitf in 89 various giant cell lesions including giant cell tumor of bone (n26), giant cell tumor of tendon sheath/pigmented villonodular synovitis (n24), giant cell reparative granuloma (n3), aneurysmal bone cysts (n11), chondroblastomas (n7), foreign body giant cell reaction (n10), and sarcoidosis (n8). " Order ALL the reference details at left...
5.	DNA (Deoxyribonucleic Acid)IBA 04/08/2005 - "Using comparative genomic hybridisation, DNA copy number changes were investigated in 15 cases of pigmented villonodular synovitis of the knee joint. " 12/01/1991 - "We performed a histological examination and DNA analysis on samples of tissue from a forty-seven-year-old woman who had a clinical diagnosis of pigmented villonodular synovitis. " 07/01/1992 - "The DNA content and proliferative indexes of seven cases of tenosynovial giant cell tumor of tendon sheath, diffuse type (TGCT-D); 11 cases of tenosynovial giant cell tumor of tendon sheath, localized type (TGCT-L); and seven cases of pigmented villonodular synovitis (PVNS) were analyzed by flow cytometry in an attempt to assess objectively their biologic differences. " 07/01/1992 - "Diffuse and localized tenosynovial giant cell tumor and pigmented villonodular synovitis: a clinicopathologic and flow cytometric DNA analysis." 01/01/2005 - "OBJECTIVE: To determine the expression of bcl-2, p53, and caspase 3, and measure the Ki-67 proliferation index as well as DNA content and DNA fragmentation in a case of diffuse pigmented villonodular synovitis (PVNS) of the knee with aggressive clinical behaviour. " Order ALL the reference details at left...
6.	AnserineIBA 07/01/2007 - "Pigmented villonodular synovitis of the pes anserine bursa." 01/01/2007 - "Pigmented villonodular synovitis of the pes anserine bursa: case report." 06/01/2003 - "Pigmented villonodular synovitis of the anserine bursa." Order ALL the reference details at left...
7.	FlexorIBA 08/01/2008 - "Magnetic resonance imaging suggested pigmented villonodular synovitis (PVNS) of her left ankle joint and flexor hallucis longus tendon. " 07/01/2000 - "[Malignant course of pigmented villonodular synovitis of the flexor tendon sheath of the small finger--case report and review of the literature]" 01/01/1990 - "At the second operation, the nodule was found to be a pigmented villonodular synovitis of the flexor tendon sheath at the palm. " 01/01/1990 - "Pigmented villonodular synovitis of flexor tendon sheath at wrist causing pseudo-carpal-tunnel syndrome: report of a case." Order ALL the reference details at left...
8.	Metalloproteases (Metalloproteinases)IBA 08/01/1994 - "Expression of metalloproteinases in pigmented villonodular synovitis." 01/01/2004 - "Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in pigmented villonodular synovitis suggests their potential role for joint destruction." 08/01/1994 - "Pigmented villonodular synovitis synovium was examined for the presence of the metalloproteinases collagenase and stromelysin. " Order ALL the reference details at left...
9.	Citric Acid (Citrate)FDA LinkGeneric 11/01/2000 - "METHOD: We studied the effect of thirteen radiosynovectomies performed in eleven pigmented villonodular synovitis patients with Y-90 citrate or Re-186 sulfide. " 10/01/1994 - "Intense uptake of pentavalent technetium-99m dimercaptosuccinic acid without gallium-67 citrate uptake indicates that pigmented villonodular synovitis has the features of a hyperplastic or neoplastic lesion rather than an inflammatory lesion from the point of view of nuclear medicine." Order ALL the reference details at left...
10.	Minocycline (Cyclops)FDA LinkGeneric 05/01/1997 - "In addition, the infrapatellar fat pad may be involved secondarily from extrinsic processes, including articular disorders (eg, joint effusion, intraarticular bodies, meniscal cyst, ganglion cyst, cyclops lesion), synovial abnormalities (eg, pigmented villonodular synovitis; hemophilia; synovial hemangioma; primary synovial chondromatosis; chondrosarcoma; lipoma arborescens; rheumatoid, seronegative, and septic arthritis; arthritis associated with inflammatory intestinal disorders; synovitis associated with primary osteoarthritis), and anterior extracapsular abnormalities. " 01/01/2005 - "Intraarticular masses can be classified as noninfectious synovial proliferative processes (lipoma arborescens, synovial osteochondromatosis, pigmented villonodular synovitis, rheumatoid arthritis), infectious granulomatous diseases (tuberculous arthritis, coccidioidomycosis arthritis), deposition diseases (gout, amyloid arthropathy), vascular malformations (synovial hemangioma, arteriovenous malformations), malignancies (synovial chondrosarcoma, synovial sarcoma, synovial metastases), and miscellaneous (cyclops lesion). " Order ALL the reference details at left...

Therapies and Procedures

1.	Arthroplasty 07/01/1999 - "In our series of 1136 patients with 1388 arthroplasties, these costs could have been eliminated for all but the twelve patients who had a suspected malignant lesion and the one patient in whom pigmented villonodular synovitis was found. " 12/01/2007 - "We describe a case of focal pigmented villonodular synovitis in the knee presenting 12 months after total knee arthroplasty. " 12/01/2007 - "An unusual case of pigmented villonodular synovitis after total knee arthroplasty." 03/01/2002 - "Total shoulder arthroplasty in pigmented villonodular synovitis: a case report." 01/01/1998 - "The three remaining patients had a history of diffuse pigmented villonodular synovitis but had no evidence of disease at the time of the arthroplasty, so a synovectomy was not performed. " Order ALL the reference details at left...
2.	Homologous Transplantation (Allograft) 06/01/2004 - "This case report describes the long-term outcome of a total bulk acetabular allograft placed for bone substitution after resection of recurrent pigmented villonodular synovitis of the hip joint. " 01/01/1991 - "A case report of recurrent pigmented villonodular synovitis of the hip joint, which was treated with en bloc resection of the acetabulum and proximal femur, followed by allograft acetabular reconstruction and total hip arthroplasty, is presented. " Order ALL the reference details at left...
3.	Intra-Articular Injections 02/01/2008 - "METHODS: Between 1989 and 2006, we treated seven patients who had diffuse pigmented villonodular synovitis of the ankle joint with subtotal synovectomy followed by intra-articular injection of 15 mCi of yttrium 90. " 02/01/2008 - "Unacceptable complications following intra-articular injection of yttrium 90 in the ankle joint for diffuse pigmented villonodular synovitis." 12/01/1989 - "The diffuse form of pigmented villonodular synovitis of eight knee joints of eight patients was treated by intra-articular injection of 185 MBq yttrium-90 silicate (90Y). " Order ALL the reference details at left...
4.	Laser Therapy (Surgery, Laser) 04/01/2001 - "Pigmented villonodular synovitis following arthroscopic laser surgery of the knee." Order ALL the reference details at left...
5.	Surgical Decompression 03/01/1996 - "These observations indicate that surgical decompression and follow-up of a patient with magnetic resonance imaging constitute a satisfactory treatment of pigmented villonodular synovitis." Order ALL the reference details at left...

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