Synephrine (Oxedrine)

09/28/2022 - "The goals of our study were to give an overview of the safety and efficacy of p-synephrine, to systematically evaluate its efficacy regarding weight loss and to assess its safety, focusing on its cardiovascular side effects in a meta-analysis. "
09/28/2022 - "Based on the analyzed clinical studies, synephrine tends to raise blood pressure and heart rate, and there is no evidence that synephrine can facilitate weight loss. "
02/24/2012 - "The lipolytic activity of p-synephrine has been repeatedly revealed by in vitro and in vivo studies and p-synephrine is currently marketed as a dietary supplement for weight loss. "
02/21/2023 - "p-Synephrine, the primary pharmacologically active protoalkaloid in Citrus species, has been popularly consumed as a dietary supplement for weight loss management. "
09/28/2022 - "The weight loss in the synephrine group was non-significant after prolonged treatment, and it did not influence body composition parameters. "

11/01/2019 - "The present study may offer invaluable opinions into the mechanisms of body weight/fat-losing activities of p-synephrine in theory, and scientific experimental evidence on dietary supplement in practice. "
01/01/2014 - "Our researches have important theoretical value for elucidating the mechanisms of p-synephrine in body weight and energy balance regulation. "
06/15/2012 - "Doses were 10 or 50mg synephrine/kg body weight from each extract. "
06/01/2011 - "Overall, doses of up to 100 mg synephrine/kg body weight did not produce developmental toxicity in Sprague-Dawley rats."
07/01/2009 - "There was a reduction in body weight gain of animals treated with both doses of p-synephrine. "

02/21/2023 - "Further assays suggested that p-synephrine treatment improved alloxan-induced decreases of glucose tolerance and insulin sensitivity. "

02/21/2023 - "In addition, p-synephrine administration inhibited renal inflammation through suppressing tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) gene expression levels, as well as CD45 expression levels. "
02/21/2023 - "p-Synephrine ameliorates alloxan-induced diabetes mellitus through inhibiting oxidative stress and inflammation via suppressing the NF-kappa B and MAPK pathways."

02/21/2023 - "However, the effects of p-synephrine on diabetes mellitus and the action mechanisms have not been clearly elucidated. "
02/21/2023 - "In conclusion, p-synephrine application significantly ameliorated alloxan-induced diabetes mellitus by inhibiting oxidative stress via suppressing the NF-κB and MAPK pathways."
02/21/2023 - "p-Synephrine ameliorates alloxan-induced diabetes mellitus through inhibiting oxidative stress and inflammation via suppressing the NF-kappa B and MAPK pathways."