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Sympatholytics

Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.
Also Known As:
Sympatholytic Agents; Sympatholytic Drugs; Sympatholytic Effect; Sympatholytic Effects; Agent, Sympatholytic; Agents, Sympathetic-Blocking; Agents, Sympatholytic; Drug, Sympatholytic; Drugs, Sympatholytic; Effect, Sympatholytic; Effects, Sympatholytic; Sympathetic Blocking Agents; Sympathetic-Blocking Agents; Sympatholytic; Sympatholytic Agent; Sympatholytic Drug
Networked: 411 relevant articles (32 outcomes, 45 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Ando, Katsuyuki: 4 articles (08/2011 - 12/2004)
2. Fujita, Toshiro: 4 articles (08/2011 - 12/2004)
3. Ormiston, T: 4 articles (01/2002 - 01/2001)
4. Salpeter, E: 4 articles (01/2002 - 01/2001)
5. Schlaich, Markus P: 3 articles (01/2022 - 11/2017)
6. Lambert, Gavin W: 3 articles (10/2020 - 11/2017)
7. Shim, Jae-Kwang: 3 articles (01/2020 - 02/2016)
8. Kario, Kazuomi: 3 articles (01/2020 - 01/2011)
9. Aragno, Manuela: 3 articles (02/2016 - 01/2016)
10. Mastrocola, Raffaella: 3 articles (02/2016 - 01/2016)

Related Diseases

1. Hypertension (High Blood Pressure)
2. Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
08/30/1985 - "The effect of hydrochlorothiazide (HCTZ) on some of these factors was compared with that of HCTZ and a sympatholytic drug in 20 hypertensive patients with left ventricular hypertrophy and retinopathy. "
06/01/1985 - "These changes in systolic and diastolic time and double and triple products may be of clinical significance during therapy of chronic systemic hypertension and may help explain the regression of left ventricular hypertrophy in patients with hypertension treated with sympathetic blocking agents."
11/01/1996 - "The present data demonstrate that an increased left ventricular mass in normotensive and in hypertensive patients is closely coupled to an increased cardiac sympathetic activity, supporting the need for additional studies to determine whether adjunctive sympatholytic therapy is beneficial in patients with left ventricular hypertrophy and increased cardiac noradrenaline release."
09/01/2012 - "The centrally-acting sympatholytic imidazoline compound, moxonidine, prevents the development of left ventricular hypertrophy and attenuates maladaptive proliferative signalling as well as downstream apoptotic pathways in spontaneously hypertensive rat and cardiomyopathic hamster hearts. "
12/01/1985 - "The left ventricular end systolic stress-end systolic dimension (ESS-ESD) relation was used to assess the effect of regression in left ventricular hypertrophy on myocardial contractility in 14 hypertensive patients (mean age 47 years) treated with guanfacine (a sympatholytic central alpha-adrenergic agonist) for 10 weeks. "
3. Complex Regional Pain Syndromes
4. Hypotension (Low Blood Pressure)
5. Insulin Resistance

Related Drugs and Biologics

1. moxonidine (Moxon)
2. Clonidine (ST 155)
3. Guanethidine
4. Dexmedetomidine
5. Antihypertensive Agents (Antihypertensives)
6. Atenolol (Tenormin)
7. Vasodilator Agents (Vasodilators)
8. Analgesics (Analgesic Drugs)
9. Reserpine (Serpasil)
10. N-Type Calcium Channels (N-Type Calcium Channel)

Related Therapies and Procedures

1. Therapeutics
2. Denervation
3. Deep Brain Stimulation
4. Low-Level Light Therapy (LLLT)
5. Ultrasonic Therapy