Chemical Sympathectomy

Sympathectomy using chemicals (e.g., 6-hydroxydopamine or guanethidine) which selectively and reversibly destroy adrenergic nerve endings while leaving cholinergic nerve endings intact.
Also Known As:
Sympathectomy, Chemical; Chemical Sympathetic Denervation; Sympathetic Denervation, Chemical; Chemical Sympathectomies; Chemical Sympathetic Denervations; Chemosympathectomies; Denervation, Chemical Sympathetic; Denervations, Chemical Sympathetic; Sympathectomies, Chemical; Sympathetic Denervations, Chemical; Chemosympathectomy; Denervation, Sympathetic, Chemical
Networked: 175 relevant articles (9 outcomes, 14 trials/studies)

Relationship Network

Therapy Context: Research Results


1. Straub, Rainer H: 3 articles (05/2014 - 06/2008)
2. Straube, Sebastian: 2 articles (01/2013 - 01/2010)
3. Derry, Sheena: 2 articles (01/2013 - 01/2010)
4. Moore, R Andrew: 2 articles (01/2013 - 01/2010)
5. Perlini, Stefano: 2 articles (07/2006 - 08/2002)
6. Ferrari, Alberto U: 2 articles (07/2006 - 08/2002)
7. Moynihan, J A: 2 articles (12/2002 - 03/2001)
8. Rice, P A: 2 articles (12/2002 - 03/2001)
9. Boehm, G W: 2 articles (12/2002 - 03/2001)
10. Stevens, S Y: 2 articles (12/2002 - 03/2001)

Related Diseases

1. Pain (Aches)
2. Anoxia (Hypoxia)
3. Hyperhidrosis
4. Pancreatitis
5. Bradycardia
11/01/1994 - "After chemical sympathetic denervation, rats presented prolonged and enlarged hyperventilation, bradycardia and systemic hypotension due to loss of adaptive baroreflex responses. "
06/01/1992 - "(G) Following chronic chemical sympathetic denervation with 6-hydroxydopamine the paradoxic bradycardia was eliminated. "
05/01/2001 - "Similarly, the increase in heart rate that follows the venom-induced bradycardia was totally inhibited by a beta(1)-adrenoceptor antagonist or by chemical sympathetic denervation with 6-hydroxydopamine. "
01/01/1982 - "In the conscious rat i.c.v. FLA-136 had less sedative potential than clonidine, in terms of overt sedation assessed visually.3 Yohimbine reduced the hypotension and bradycardia produced by i.c.v. FLA-136 and clonidine; prazosin and mianserin also antagonized the cardiovascular responses to clonidine, but not those to FLA-136.4 Chemical sympathectomy by 6-hydroxydopamine (6-OHDA) markedly reduced the cardiovascular effects of FLA-136 but only slightly reduced those of clonidine.5 Naloxone antagonized the cardiovascular responses to clonidine, but not FLA-136, suggesting a direct or indirect involvement of central opiate receptors in the responses induced by clonidine.6 Metiamide attenuated the cardiovascular responses to FLA-136 and clonidine, implying a direct or indirect involvement of central histamine (H(2))-receptors in such responses.7 FLA-136, unlike clonidine, did not stimulate peripheral pre- or postsynaptic alpha-adrenoceptors in the pithed rat.8 FLA-136 is a novel centrally-acting hypotensive compound which, unlike clonidine, selectively stimulates central alpha-autoreceptors (yohimbine-sensitive) in the rat; these autoreceptors may be different from peripheral pre- and postsynaptic alpha-adrenoceptors. "

Related Drugs and Biologics

1. Oxidopamine (6 Hydroxydopamine)
2. Phenol (Carbolic Acid)
3. Glycerol (Glycerine)
4. Norepinephrine (Noradrenaline)
5. Insulin (Novolin)
6. Fructose
7. Epinephrine (Adrenaline)
8. Interleukin-6 (Interleukin 6)
9. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
10. Lidocaine (Xylocaine)

Related Therapies and Procedures

1. Adrenalectomy
2. Injections
3. Sympathectomy (Sympathectomies)
4. Ligation
5. Transplants (Transplant)