Gustatory Sweating (Frey's Syndrome)

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152 relevant articles (24 outcomes, 8 trials/studies) found for this Disease

Description: An autonomic disorder characterized by excessive sweating of the forehead, upper lip, perioral region, or sternum subsequent to gustatory stimuli. The auriculotemporal syndrome features facial flushing or sweating limited to the distribution of the auriculotemporal nerve and may develop after trauma to the parotid gland, in association with PAROTID NEOPLASMS, or following their surgical removal. (From Ann Neurol 1997 Dec;42(6):973-5)

Also Known As:

Frey's Syndrome; Syndrome, Frey's; Sweating, Gustatory; Salivosudoriparous Syndrome; Von Frey Syndrome; Von Frey's Syndrome; Freys Syndrome; Gustatory Hyperhidroses; Gustatory Hyperhidrosis; Hyperhidroses, Gustatory; Salivosudoriparous Syndromes; Syndrome, Auriculotemporal; Syndrome, Baillarger; Syndrome, Frey; Syndrome, Salivosudoriparous; Syndrome, Von Frey; Syndrome, Von Frey's; Syndromes, Salivosudoriparous; Von Freys Syndrome; Auriculotemporal Syndrome; Baillarger Syndrome; Frey Syndrome; Hyperhidrosis, Gustatory

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 3424

Autonomic Nervous System Diseases: 256

Gustatory Sweating: 152

Skin and Connective Tissue Diseases

Skin Diseases: 5948

Sweat Gland Diseases

Hyperhidrosis: 874

Gustatory Sweating: 152

Related Diseases

1.	Gustatory Sweating (Frey's Syndrome)
2.	Hyperhidrosis
3.	Syndrome
4.	Lacrimal Apparatus Diseases (Epiphora)
5.	Deglutition Disorders (Dysphagia)

Experts

1.	Guntinas-Lichius, Orlando: 2 articles (11/2003 - 04/2002)
2.	Eleopra, R: 2 articles (06/2002 - 03/2001)
3.	Tugnoli, V: 2 articles (06/2002 - 03/2001)
4.	De Grandis, D: 2 articles (06/2002 - 03/2001)
5.	Montecucco, C: 2 articles (06/2002 - 03/2001)
6.	Marchese Ragona, R: 2 articles (06/2002 - 03/2001)
7.	Bergé, S: 2 articles (12/2000 - 10/2000)
8.	von Lindern, J J: 2 articles (12/2000 - 10/2000)
9.	Niederhagen, B: 2 articles (12/2000 - 10/2000)
10.	Reich, R H: 2 articles (12/2000 - 10/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Gustatory Sweating:

1.	Botulinum Toxins (Botulinum Toxin)IBA 10/01/2001 - "Intracutaneous injections of botulinum toxin A are highly effective and safe in treatment of gustatory sweating." 05/01/1995 - "It is concluded that local botulinum toxin injections are a highly effective and safe treatment for Frey's syndrome" 10/15/2000 - "RESULTS: In the current study, seven patients with severe, symptomatic Frey syndrome after parotidectomy were treated successfully with type A botulinum toxin" 01/01/2002 - "CONCLUSION: Botulinum toxin A produces good results in the treatment of Frey syndrome" 08/01/2007 - "Intracutaneous injection of botulinum toxin A is an effective, long-lasting, and well-tolerated treatment of Frey syndrome" Order ALL the reference details at left...
2.	Botulinum Toxin Type A (Botox)FDA Link 04/01/2002 - "CONCLUSIONS: Using a higher concentration of botulinum toxin type A (20 MU Dysport/0.1 mL) is more effective than a lower concentration (10 MU Dysport/0.1 mL) in the treatment of Frey's syndrome." 04/01/2002 - "Increased botulinum toxin type A dosage is more effective in patients with Frey's syndrome." 11/01/2007 - "CONCLUSION: Intradermal injection of botulinum toxin type A for patients with Frey's syndrome is not only effective with no side effect but also minimally invasive" 08/01/2003 - "CONCLUSION: Botox A injection is a safe and effective treatment with long-lasting effects for patients with extensive gustatory sweating." 06/01/1999 - "Such preliminary data, together with the review of the literature suggests, that the intracutaneous injection of botulinum toxin type A should now be the first line treatment option in patients with severe Frey syndrome." Order ALL the reference details at left...
3.	Glycopyrrolate (Glycopyrronium Bromide)FDA LinkGeneric 04/26/1999 - "RESULTS: Gustatory sweating was relieved by application of glycopyrrolate and reappeared when the glycopyrrolate was briefly withdrawn to confirm its therapeutic effect" 05/01/1996 - "Topical glycopyrrolate cream is an effective treatment of diabetic gustatory sweating without the adverse effects commonly found with oral anti-muscarinic medication." 01/01/1989 - "We therefore believe that the topical application of a 2% glycopyrrolate preparation is a safe and effective treatment for severe gustatory sweating following parotidectomy." 03/01/1997 - "A randomised controlled trial of topical glycopyrrolate, the first specific treatment for diabetic gustatory sweating." 10/01/2005 - "Oral glycopyrrolate for the treatment of diabetic gustatory sweating." Order ALL the reference details at left...
4.	Starch (Cornstarch)IBA 01/01/2000 - "However, analysis of the current results in patients with SMAS dissection revealed an incidence of Frey's syndrome of only 20%, the results of starch minor tests being positive in 76% with a statistically highly significant (p = 0.006) decrease in extent and intensity" 01/01/2000 - "In a previous publication we found a 43% incidence of Frey's syndrome after parotid surgery without SMAS dissection and starch minor tests were positive in all 23 patients" 09/01/1997 - "Minor's starch test showed total disappearance of gustatory sweating in 12 of the 15 treated patients" 07/01/1976 - "Because the starch test reveals only the distribution of the gustatory sweating, a useful adjunct is described for investigating Frey's syndrome" 03/01/1997 - "In four patients who had undergone unilateral parotidectomy, gustatory sweating and facial flushing were present after gustatory stimulation, and the presence of Frey's syndrome was confirmed with Minor's starch test in all patients" Order ALL the reference details at left...
5.	IodineIBA 10/01/1993 - "Only one patient developed symptomatic Frey's syndrome, and one other patient had positive results on starch iodine testing" 08/01/2008 - "All of the patients were evaluated using a short questionnaire; postoperative gustatory sweating was assessed using a modification of Minor's starch-iodine test." 06/01/2008 - "The incidence of Frey's syndrome was clinically evaluated by Minor test (starch-iodine test)" 11/01/2004 - "PATIENTS AND METHOD: Twenty patients suffering from severe Frey's syndrome as a result of operations of the parotid gland were examined with the starch iodine test according to Minor" 06/01/2004 - "Minor's starch iodine test [14], confirmed the gustatory sweating in the left preauricular area" Order ALL the reference details at left...
6.	CosmeticsIBA 06/01/2008 - "CONCLUSIONS: The modified parotidectomy is a function-preserving surgery for benign parotid tumours, which improves the cosmetics, the feeling around ear, reduces the duration of surgery, and the incidence rate of Frey's syndrome" 04/01/2008 - "RESULTS: After a minimum follow up of 24 months, Frey's syndrome (FS) and cosmetic appearance were evaluated" 12/01/2007 - "Partial parotidectomy or extracapsular dissection results in impaired cosmetic results and a lower incidence of Frey's syndrome, and thus may be the preferred approach when undertaken by experienced surgeons." 03/01/2007 - "Selective deep lobe parotidectomy is a demanding technique, but it preserves healthy glandular tissue, improves cosmetic results and minimises the incidence of Frey's syndrome" 12/01/2002 - "Parotid surgery can cause postoperative facial nerve dysfunction, cosmetic impairment, and Frey's syndrome" Order ALL the reference details at left...
7.	CollagenIBA 04/01/1997 - "Early results using a porcine dermal collagen implant as an interpositional barrier to prevent recurrent Frey's syndrome." 08/01/2006 - "CONCLUSIONS: Use of collagen pieces as an interposition fill barrier improves parotidectomy outcome by reducing the incidence of Frey syndrome, and it improves cosmetic results concurrently." 07/01/2002 - "This survey presents both established treatments as well as newly developed applications in craniomaxillofacial surgery: (1) the treatment of dysfunctions of the masticatory muscular system, (2) the correction of marked imbalances of the mimic muscular system resulting from surgical treatment, (3) the therapy of salivary gland-associated malfunctions, such as hypersalivation or Frey's syndrome, (4) aesthetic corrections with botulinum toxin A as a single therapy or in combination with collagen injections, (5) EMG-controlled injection of botulinum toxin A as an alternative to surgical treatment of recurrent dislocation of the TMJ, (6) prophylaxis to prevent relapse after mandibular advancement by EMG-controlled paralysis of the geniohyoid muscles." Order ALL the reference details at left...
8.	ADM protocolIBA 12/01/2008 - "Objectively Frey's syndrome was found in 24 patients from the control group (23%) and 2 patients from the ADM group (2%)" 12/01/2008 - "RESULTS: Subjectively Frey's syndrome was recorded in 63 patients (61%) from the controls and one patient (2%) from the ADM group" 09/01/2007 - "RESULTS: The incidences of Frey syndrome were 13.3% in ADM group and 55.6% in control group" 09/01/2007 - "OBJECTIVE: To evaluate the clinical effect of acellular dermal matrix (ADM) on preventing Frey syndrome after parotidectomy" 12/01/2008 - "CONCLUSION: The use of acellular dermal matrix (ADM) as an interpositional graft is an effective way of preventing Frey's syndrome after parotidectomy." Order ALL the reference details at left...
9.	Lactic Acid FDA LinkGeneric 01/01/1994 - "The L lactate biosensor appears to be an interesting tool for Frey's syndrome analysis" 01/01/1994 - "Contribution of L lactate and amino-acid enzymatic biosensors for the analysis of Frey syndrome]" 09/01/1993 - "MAIN OUTCOME AND MEASURES: Gustatory sweating was assessed in all patients using a clinical scale, the Minor starch iodine test, and the L-lactate biosensoring method" Order ALL the reference details at left...
10.	Scopolamine (Hyoscine)FDA Link 04/01/1977 - "Three months after the trauma, the patient had gustatory sweating, which was controlled with topical applications of scopolamine hydrobromide." 05/01/1976 - "A case of Frey's syndrome is reported The patient obtained good relief of symptoms with scopolamine cream and atropine cream" Order ALL the reference details at left...

Therapies and Procedures

1.	Sympathectomy (Sympathectomies) 03/01/2006 - "Although there is no pathophysiologic explanation of gustatory sweating, these findings should be considered before planning thoracoscopic sympathectomy and patients should be thoroughly informed." 03/01/2006 - "CONCLUSIONS: Gustatory sweating is a frequent side effect after thoracoscopic sympathectomy" 03/01/2006 - "Overall, gustatory sweating occurred in 32% of patients, and the incidence was significantly associated with extent of sympathectomy (p = 0.04)" 05/01/2003 - "Additional data regarding sensory findings, surgical details of the sympathectomy, sweat patterns, and incidence of abnormal body sweating and pathologic gustatory sweating were extracted from the patients' charts or obtained in follow-up appointments" 10/01/1977 - "In a series of 100 bilateral upper dorsal sympathectomies performed for palmar hyperhidrosis, gustatory sweating and other gustatory phenomena were reported by 68 of 93 patients (73%), followed up for an average of 1 1/2 years" Order ALL the reference details at left...
2.	Kidney Transplantation 12/01/1996 - "Five subjects reported that gustatory sweating either disappeared or significantly improved immediately after renal transplantation" Order ALL the reference details at left...
3.	Neck Dissection (Radical Neck Dissection) 06/01/1999 - "PATIENTS AND METHODS: This study summarizes the statements of 548 patients questioned about the occurrence of gustatory sweating after parotidectomy (n = 296), extirpation of the submandibular gland (n = 79), and neck dissection (n = 173)" 06/01/1999 - "PURPOSE: It was the aim of this study to provide detailed general information on the clinical picture of different kinds of gustatory sweating, including reevaluation of a series of patients who underwent parotidectomy, removal of the submandibular gland, or neck dissection" 06/01/1999 - "After submandibular extirpation and neck dissection, some patients reported gustatory sweating that was not verified by Minor's test" 06/01/1999 - "Gustatory sweating developed in only one patient with submandibular extirpation (1.5%), and not at all after neck dissection" 06/01/1970 - "Gustatory sweating after radical neck dissection." Order ALL the reference details at left...
4.	Transplants (Transplant) 03/01/1991 - "The dermal-fat graft also serves as a barrier to regenerating neurons, thereby preventing postoperative gustatory sweating." 10/01/1980 - "Treatment of frey's syndrome by an interpositional fascia graft: report of case." 01/01/1978 - "Gustatory sweating following parotidectomy: correction by a fascia lata graft." 06/01/1977 - "Since Frey's syndrome is due to the aberrent regeneration of parasympathetic nerve fibers of the parotid gland into the severed sympathetic nerve endings in skin overlying the gland, it is proposed that the insertion of a dermal graft barrier between the resected parotid gland and the skin will prevent Frey's syndrome" 06/01/1977 - "A new concept in the treatment of Frey's syndrome: the use of interpositional dermal grafts" Order ALL the reference details at left...
5.	Osteotomy 11/01/1998 - "A patient with Frey syndrome on the left cheek area as a complication of an Obwegeser osteotomy is reported" 11/01/1998 - "Atypical Frey syndrome as a complication of Obwegeser osteotomy." 07/01/1983 - "Frey's syndrome as a postoperative complication in the correction of condylar and mandibular angle fractures and following bilateral segmental osteotomy of the mandibular angle]" 04/01/1968 - "Auriculotemporal syndrome secondary to vertical sliding osteotomy of the mandibular rami: report of case." 01/01/1960 - "Gustatory hyperhidrosis associated with subcondylar osteotomy." Order ALL the reference details at left...

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