Suramin (Suramin Sodium)

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690 relevant articles (48 outcomes, 154 trials/studies) found for this Bio-Agent

Description: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.

Also Known As:

Suramin Sodium; Germanin; Moranil; Naganin; Naganol; Naphuride; Suramin, Hexasodium Salt; Suramin, Monosodium Salt; Hexasodium Salt Suramin; Monosodium Salt Suramin; Salt Suramin, Hexasodium; Salt Suramin, Monosodium; Sodium, Suramin; 1,3,5-Naphthalenetrisulfonic acid, 8,8'-(carbonylbis(imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino))bis-

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 42

Hydrocarbons: 362

Cyclic Hydrocarbons: 3

Aromatic Hydrocarbons: 121

Aromatic Polycyclic Hydrocarbons: 617

Naphthalenes: 10

Naphthalenesulfonates: 2

Suramin: 690

XAMR 0721: 1

6-((4,6,8-trisulfo-1-naphthyl)iminocarbonyl-1,3-(4-methylphenylene)iminocarbonyl-1,3-phenyleneazo)pyridoxal-5'-phosphate

8,8',8'',8'''-(carbonylbis(imino-5,13-benzenetriyl-bis(carbonylimino)))tetrakisnaphthalene-1,3,5-trisulfonic acid

Naphthalenesulfonates: 2

Suramin: 690

XAMR 0721: 1

6-((4,6,8-trisulfo-1-naphthyl)iminocarbonyl-1,3-(4-methylphenylene)iminocarbonyl-1,3-phenyleneazo)pyridoxal-5'-phosphate

8,8',8'',8'''-(carbonylbis(imino-5,13-benzenetriyl-bis(carbonylimino)))tetrakisnaphthalene-1,3,5-trisulfonic acid

Polycyclic Compounds: 59

Aromatic Polycyclic Hydrocarbons: 617

Naphthalenes: 10

Naphthalenesulfonates: 2

Suramin: 690

XAMR 0721: 1

6-((4,6,8-trisulfo-1-naphthyl)iminocarbonyl-1,3-(4-methylphenylene)iminocarbonyl-1,3-phenyleneazo)pyridoxal-5'-phosphate

8,8',8'',8'''-(carbonylbis(imino-5,13-benzenetriyl-bis(carbonylimino)))tetrakisnaphthalene-1,3,5-trisulfonic acid

Experts

1.	Wientjes, M Guillaume: 4 articles (09/2006 - 08/2003)
2.	Ratain, Mark J: 4 articles (11/2004 - 07/2002)
3.	Vogelzang, Nicholas J: 4 articles (11/2004 - 07/2002)
4.	Au, Jessie L-S: 3 articles (07/2005 - 08/2003)
5.	Hotz, Hubert G: 2 articles (05/2008 - 02/2007)
6.	Hotz, Birgit: 2 articles (05/2008 - 02/2007)
7.	Buhr, Heinz J: 2 articles (05/2008 - 02/2007)
8.	Chen, Danny: 2 articles (07/2005 - 08/2003)
9.	Wilding, George: 2 articles (11/2004 - 08/2002)
10.	Palchak, David: 2 articles (11/2004 - 08/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1993 - "Suramin, a highly sulfonated drug, has been reported to be effective against several human malignancies in vitro and in vivo, and currently is undergoing clinical trials against prostate tumors. " 05/01/2008 - "Suramin therapy resulted in a complete regression of tumor macrovessels and a significant reduction of microvessel density. " 01/01/1999 - "PURPOSE: Suramin, a polysulfonated naphthylurea, has been shown to be effective in the treatment of several cancers. " 05/01/1997 - "The results establish that suramin is effective in controlling growth in colonic tumor cells and confirms that suramin activity is synergistic with other chemotherapeutics. " 08/16/2005 - "Although it has shown clinical promise in treatment of several cancers, suramin has many undesirable side effects. " Order ALL the reference details at left...
2.	Infection 03/01/1994 - "The synergism of DFMO and suramin against an acute infection was improved when suramin was given at the end of the DFMO administration. " 06/01/2007 - "Central nervous system involvement and its relationship with suramin treatment failure were assessed in 60 patients with parasitologically confirmed hemolymphatic-stage Trypanosoma brucei gambiense infection (white blood cell count of <or=5/microl and no trypanosomes in the cerebrospinal fluid [CSF]). " 12/01/2002 - "Suramin does not cross the blood-brain barrier efficiently and therefore, at normal dosages, will not cure CNS-stage infections. " 11/01/1995 - "Suramin treatment of experimental Trypanosoma brucei infection of the central nervous system." 09/30/1994 - "Taken together, these results suggest that suramin blocks HIV-1 infection in HT-29 cells because it binds to the V3 domain of gp120 and hence prevents the interaction between gp120 and the GalCer receptor." Order ALL the reference details at left...
3.	Trypanosomiasis 08/01/1989 - "Six of nine goats with cerebral trypanosomiasis induced by this stock were cured by a single high dose of suramin (50 mg kg-1). " 10/01/2006 - "The first reported human case of trypanosomiasis caused by Trypanosoma evansi was treated using suramin. " 05/01/1994 - "Suramin is a polysulfonated naphthylurea developed originally to treat trypanosomiasis. " 07/15/1993 - "Suramin has long been used for the treatment of Gambian and Rhodesian trypanosomiasis and oncocerciasis. " 08/01/1992 - "Suramin is a polyanionic compound used clinically for the treatment of trypanosomiasis, which is known to inhibit the action of many protein factors in vitro. " Order ALL the reference details at left...
4.	Prostatic Neoplasms (Prostate Cancer) 03/01/2000 - "Androgen deprivation and four courses of fixed-schedule suramin treatment in patients with newly diagnosed metastatic prostate cancer: A Southwest Oncology Group Study." 03/01/1999 - "Recent studies have proved the effect of suramin on prostate cancer. " 01/01/1999 - "In discussions on the utility of suramin our data should be considered as support for continuing the study of suramin in the treatment of advanced, androgen-independent prostate cancer." 11/11/1997 - "Suramin is an experimental antineoplastic agent which is currently being tested in clinical trials for its utility in treating breast and prostate cancer. " 08/01/1997 - "Suramin has demonstrated modest activity against prostate cancer and is being investigated in clinical trials. " Order ALL the reference details at left...
5.	Carcinoma (Carcinomatosis) 04/01/1992 - "In the present study, we have investigated the efficacy of suramin in a carcinoma model system. " 06/20/2005 - "Phase I trial of intravesical Suramin in recurrent superficial transitional cell bladder carcinoma." 02/01/1994 - "Ongoing clinical trials have confirmed the effect of suramin on metastasizing prostate carcinoma. " 02/01/1993 - "The current study was done to assess the effect of suramin at clinically relevant doses on the growth in culture of a human prostatic carcinoma cell line, PC-3. " 09/01/1992 - "The present study was undertaken to investigate the effects of suramin on normal human thyroid cells in primary monolayer culture and to analyse whether it also affected cells from thyroid carcinomas. " Order ALL the reference details at left...

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