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Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome)

A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei. (From Adams et al., Principles of Neurology, 6th ed, pp1076-7)
Also Known As:
Steele Richardson Olszewski Syndrome; Progressive Supranuclear Ophthalmoplegia; Supranuclear Palsy, Progressive; Palsy, Progressive Supranuclear; Steele-Richardson-Olszewski Disease; Ophthalmoplegias, Progressive Supranuclear; Progressive Supranuclear Ophthalmoplegias; Progressive Supranuclear Palsies; Steele Richardson Olszewski Disease; Supranuclear Ophthalmoplegia, Progressive; Supranuclear Ophthalmoplegias, Progressive; Supranuclear Palsies, Progressive; Syndrome, Steele-Richardson-Olszewski; Ophthalmoplegia, Progressive Supranuclear; Steele-Richardson-Olszewski Syndrome
Networked: 678 relevant articles (13 outcomes, 85 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Muscle Rigidity
2. Paresis (Hemiparesis)
3. Parkinson Disease (Parkinson's Disease)
4. Alzheimer Disease (Alzheimer's Disease)
5. Multiple System Atrophy

Experts

1. Dickson, Dennis W: 14 articles (08/2012 - 10/2002)
2. Trojanowski, John Q: 12 articles (12/2013 - 05/2002)
3. Lees, Andrew J: 11 articles (06/2014 - 07/2003)
4. Josephs, Keith A: 10 articles (03/2015 - 10/2002)
5. Hasegawa, Masato: 10 articles (01/2013 - 04/2002)
6. Litvan, Irene: 9 articles (07/2014 - 09/2002)
7. Miller, Bruce L: 8 articles (09/2015 - 03/2004)
8. de Silva, Rohan: 8 articles (06/2014 - 07/2003)
9. Ferrer, I: 8 articles (09/2013 - 01/2001)
10. Lees, A J: 8 articles (07/2006 - 12/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Progressive Supranuclear Palsy:
1. Citric Acid (Citrate)FDA LinkGeneric
2. tandospironeIBA
3. tau Proteins (tau Protein)IBA
4. Levodopa (L Dopa)FDA LinkGeneric
5. zolpidem (Ambien)FDA LinkGeneric
6. SilverIBA
7. Adenosine Triphosphate (ATP)IBA
8. Amitriptyline (Elavil)FDA LinkGeneric
9. Dopamine Agonists (Dopamine Agonist)IBA
10. Botulinum Toxins (Botulinum Toxin)IBA

Therapies and Procedures

1. Enteral Nutrition (Feeding, Tube)
2. Therapeutics
3. Deep Brain Stimulation
4. Transplants (Transplant)
5. Transplantation (Transplant Recipients)