A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei. (From Adams et al., Principles of Neurology, 6th ed, pp1076-7)
Also Known As:
Steele Richardson Olszewski Syndrome; Progressive Supranuclear Ophthalmoplegia; Supranuclear Palsy, Progressive; Palsy, Progressive Supranuclear; Richardson's Syndrome; Steele-Richardson-Olszewski Disease; Supranuclear Palsy, Progressive, 1; Progressive Supranuclear Palsies; Richardson Syndrome; Steele Richardson Olszewski Disease; Supranuclear Ophthalmoplegia, Progressive; Supranuclear Palsies, Progressive; Ophthalmoplegia, Progressive Supranuclear; Progressive Supranuclear Palsy 1; Steele-Richardson-Olszewski Syndrome