Suppositories (Vaginal Suppositories)

Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.

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Networked: 995 relevant articles (106 outcomes, 158 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Karunajeewa, Harin A: 4 articles (04/2007 - 03/2003)
2.	Novikova, E G: 3 articles (05/2022 - 11/2021)
3.	Troitsky, A V: 3 articles (05/2022 - 11/2021)
4.	Ukah, H U: 3 articles (05/2022 - 11/2021)
5.	Neĭmark, A I: 3 articles (01/2013 - 07/2011)
6.	Fink, Klaus G: 3 articles (01/2010 - 11/2005)
7.	Karpukhin, I V: 3 articles (01/2010 - 09/2004)
8.	Davis, Timothy M E: 3 articles (04/2007 - 08/2004)
9.	van Gijn, J: 3 articles (09/2006 - 02/2000)
10.	Ilett, Kenneth F: 3 articles (03/2006 - 03/2003)

Related Diseases

1.	Proctitis 12/01/1987 - "5-ASA suppositories are safe, well-tolerated, and effective treatment for active distal proctitis." 02/01/2019 - "A total of 23 patients with ulcerative proctitis presented to follow-up within ≤50 days (mean 27.0 days) after suppositories were started. " 10/01/2006 - "Suppositories should be considered the treatment of choice for proctitis and distal sigmoiditis. " 12/01/1987 - "Double-blind, placebo-controlled evaluation of 5-ASA suppositories in active distal proctitis and measurement of extent of spread using 99mTc-labeled 5-ASA suppositories." 08/02/1947 - "Granular proctitis treated with succinyl-sulphathiazole suppositories."
2.	Pain (Aches) 04/01/1990 - "Conventional fatty-based suppositories have a place in the management of chronic pain but the variability in dissolution and drug absorption limit their usefulness. " 03/01/1995 - "Treatment with sCT suppositories caused a statistically significant decrease of pain in both study groups. " 02/01/2019 - "Traditional solid suppositories can cause pain and discomfort for patients, may reach the end of the colon; consequently, the drug can undergo the first-pass effect. " 08/01/2016 - "The use of non-steroidal anti-inflammatory rectal suppositories was found to be a simple and highly effective modality of reducing the perineal pain." 08/01/2006 - "If given the choice for future surgeries, many parents would switch or consider switching from oral pain medication to suppositories."
3.	Ulcerative Colitis 01/01/1983 - "In a cross-over trial in 5 patients with ulcerative colitis no difference, was found in the dose-corrected mean (+/- SD) steady state plasma levels (Css) of 5-AS and AcAS between treatment with 5-AS suppositories (0.10 +/- 0.07 and 0.50 +/- 0.20 micrograms/ml, respectively) and SZ (0.12 +/- 0.14 and 0.67 +/- 0.14 micrograms/ml, respectively). " 12/01/2023 - "3D printed multi-drug-loaded suppositories for acute severe ulcerative colitis." 01/01/2021 - "In summary, this article reports on the fabrication of 3D printed self-supporting suppositories to deliver personalised doses of a narrow therapeutic index drug, with potential benefits for patients with ulcerative colitis." 07/01/1999 - "Practicality of 5-aminosalicylic suppositories for long-term treatment of inactive distal ulcerative colitis." 12/01/2007 - "We recently experienced a case of acute pancreatitis caused by 5-ASA suppositories in a patient with ulcerative colitis. "
4.	Inflammation (Inflammations) 12/01/2023 - "As inflammation is localised in the rectum and colon, local drug delivery using suppositories could improve therapeutic outcomes. " 06/08/2016 - "We also observed an improvement in the main storage symptoms and clinical findings associated with lower urinary tract inflammation in patients treated with beclomethasone dipropionate suppositories." 06/08/2016 - "The purpose of this study was to observe the efficacy and safety of beclomethasone dipropionate rectal suppositories (Topster®) in inflammations of the lower urinary tract in men. " 08/01/2013 - "The effectiveness of mesalazine suppositories in all types of UC patients with rectal inflammation was confirmed for the first time in a double-blind, placebo-controlled, parallel-group study (JapicCTI- 111421)." 06/08/2016 - "An observational study of the use of beclomethasone dipropionate suppositories in the treatment of lower urinary tract inflammation in men."
5.	Prostatitis 03/01/2023 - "The study showed that the use of Prostatex rectal suppositories 10 mg had a positive effect on the main indicators of spermatogenesis, as well as on the subjective and objective symptoms of chronic abacterial prostatitis. " 03/01/2023 - "Based on these results, we recommend Prostatex rectal suppositories to patients with chronic abacterial prostatitis, accompanied by impaired spermatogenesis, according to the scheme: 1 suppository 10 mg 1 time per day for 30 days." 03/01/2010 - "The objective of the present paper was to evaluate the effectiveness of Suppeksol rectal suppositories applied either as a self-contained therapeutic means or in combination with natural spa-and-resort factors for the rehabilitative treatment of patients with chronic infectious prostatitis. " 03/01/2010 - "[Evaluation of the effectiveness of rectal suppositories containing a dense extract from licorice roots at the stage of spa-and-resort rehabilitation of patients with chronic infectious prostatitis]." 07/01/2003 - "[Use of tambuil suppositories in the treatment of chronic prostatitis]."

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2.	Dinoprostone (PGE2)
3.	Progesterone
4.	Indomethacin (Indometacin)
5.	Metronidazole (Metric)
6.	Diclofenac (SR 38)
7.	Artesunate
8.	Steroids
9.	Nonoxynol (Nonoxynol 9)
10.	Butyrates (Butyrate)

Related Therapies and Procedures

1.	Enema (Enemas)
2.	Therapeutics
3.	Rectal Administration
4.	Induced Labor
5.	Condoms (Condom)