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Sulindac (Copal)

691  relevant articles (60 outcomes, 143 trials/studies) found for this Drug

Description: A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.

Also Known As:
Copal; Clinoril; Aclin; Alphapharm Brand of Sulindac; Apo-Sulin; Apotex Brand of Sulindac; Arthrobid; Arthrocine; Cahill May Roberts Brand of Sulindac; Chemia Brand of Sulindac; Chibret; Kenalin; Kendrick Brand of Sulindac; Klinoril; MK-231; Merck Brand of Sulindac; Merck Sharp & Dohme Brand of Sulindac; Novo-Sundac; Novopharm Brand of Sulindac; Nu-Pharm Brand of Sulindac; Nu-Sulindac; Sulindal; Apo Sulin; MK 231; MK231; Novo Sundac; Nu Pharm Brand of Sulindac; Nu Sulindac; 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-, (Z)-

Relationship Network

Drug Context: Research Results

Experts

1. Giardiello, Francis M: 6 articles (10/2005 - 03/2002)
2. Rhee, Chang-Hun: 5 articles (09/2008 - 02/2005)
3. Jin, Hyeon-Ok: 5 articles (09/2008 - 02/2005)
4. Park, In-Chul: 5 articles (09/2008 - 02/2005)
5. An, Sungkwan: 5 articles (09/2008 - 02/2005)
6. Lee, Hyung-Chahn: 5 articles (09/2008 - 02/2005)
7. Yoo, Doo-Hyun: 5 articles (09/2008 - 02/2005)
8. Lee, Su-Jae: 5 articles (09/2008 - 02/2005)
9. Hong, Seok-Il: 5 articles (09/2008 - 02/2005)
10. Woo, Sang-Hyeok: 5 articles (09/2008 - 02/2005)

Related Diseases

1. Neoplasms (Cancer)
2. Adenomatous Polyposis Coli (Familial Adenomatous Polyposis)
3. Adenoma (Adenomas)
4. Polyps
02/20/1996 - "A second study reported that intervention with the NSAID sulindac for 9 months in young patients with FAP resulted in a significant reduction in both polyp number and size in the rectosigmoid colon"
08/01/2007 - "Participants in the Phase IIb study served as a vanguard for a randomized, placebo-controlled prospective Phase III trial of the combination of DFMO and sulindac with the primary study endpoint the prevention of colon polyps"
09/01/1995 - "Despite attempts to reduce polyp mass by regular endoscopic polypectomy, daily transfusions of blood products, and a trial of the non-steroidal anti-inflammatory agent sulindac, his condition gradually deteriorated and he died of septicaemia."
05/06/1993 - "Administration of the nonsteroidal antiinflammatory drug sulindac has been followed by regression of polyps in patients with this disorder, but no controlled trial of this drug in patients who have not had surgery has been reported"
10/01/2005 - "Six patients exhibited polymorphisms in both E158K and E308G loci and were designated as genotype combination 1. The remaining patients were designated as genotype combination 2. Over the course of treatment, patients with genotype combination 1 had a greater reduction in both the size and number of polyps than those with genotype combination 2. These results suggest that combined polymorphic changes in the E158K and E308G alleles may protect against polyposis in patients with FAP treated with sulindac."
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5. Rheumatoid Arthritis

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