Sulfones

07/01/2013 - "The improvement in living standards and the use of sulfones finally resulted in the control of leprosy. "
04/01/1968 - "Studies on sulfone resistance in leprosy. "
10/01/1966 - "Studies on sulfone resistance in leprosy. "
10/01/1966 - "Studies on sulfone resistance in leprosy. "
10/31/1956 - "[Study of blood sulfone after administration of a preparation of solubilized DDS to leprosy patients]."

01/01/1962 - "Studies on the toxicity and action of diaminodiphenyl-sulfone (DDS) in avian and simian malaria."
09/01/1945 - "The sulfone in malaria therapy."
02/26/2009 - "Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells."
01/01/1973 - "Considerations on the use of sulfones and sulfamides with a pyrimidine derivative by the malaria control service of Mocambique."
12/01/2018 - "When the sulfoxide was dosed, the exposure of the sulfone achieved was as much as 2.9-fold higher than when the sulfone was directly dosed, thereby demonstrating that the sulfoxide served as an effective prodrug for the treatment of malaria."

07/01/2010 - "The therapeutic role of sulfones related to both pathogen-caused diseases and chronic inflammatory dermatoses has led to extensive use in dermatology. "
04/01/1978 - "[Use of sulfone in skin diseases]."
08/01/1963 - "DERMATITIS HERPETIFORMIS: A CHRONIC DERMATOSIS YIELDS TO SULFONES."
02/01/1960 - "[Use of sulfone preparations in the treatment of psoriasis and certain dermatoses]."
10/01/2011 - "Dapsone, a synthetic sulfone, is widely used to treat chronic neutrophil dermatoses. "

09/01/2001 - "Toxicology and carcinogenesis studies of p,p'-dichlorophenyl sulfone (CAS No. 80-07-9) in F344/N rats and B6C3F1 mice (feed studies)."
03/01/2001 - "Toxicology and carcinogenesis studies of p,p'-dichlorodiphenyl sulfone in rats and mice."
07/01/2000 - "Three sulfones and the 1 beta-hydroxymethyl hybrid were evaluated as inhibitors of multistage carcinogenesis in mouse skin. "
01/15/1997 - "A candidate mechanism for the apparent clonal selection pressure exerted by the sulfone against mammary carcinogenesis is apoptosis. "
01/15/1997 - "These data indicate that the observed effect of the sulfone on mammary carcinogenesis in vivo is likely to be due to a tissue-specific effect rather than to other systemic effects. "

01/01/2022 - "In this study, a new series of 18F-labeled PSMA-targeting agents was developed based on the high-affinity Glu-ureido-Lys scaffold and 18F-vinyl sulfones (VSs), the tumor uptake and tumor/major organ contrast of which could be tuned by pharmacokinetic linkers within the molecules. "
03/15/2022 - "These trifluoromethyl-substituted vinyl sulfones are further evaluated for several assays against different tumor cells and the antitumor mechanism in cytotoxic autophagy induced by PI3K/Akt/mTOR signal is investigated."
06/05/2021 - "Thereafter, the anti-proliferative action for sulfones 5f, 8a and 8d was examined against breast (MCF-7) and colon (HCT-116) cancer cell lines. "
11/01/2006 - "Biological evaluation of sulfone derivatives as anti-inflammatory and tumor cells growth inhibitory agents."
07/15/1997 - "Sulfone-treated rats also showed a dose-response relationship for inhibiting all tumor parameters. "