Sulfhemoglobinemia

A morbid condition due to the presence of sulfmethemoglobin in the blood. It is marked by persistent cyanosis, but the blood count does not reveal any special abnormality in the blood. It is thought to be caused by the action of hydrogen sulfide absorbed from the intestine. (Stedman, 25th ed)

Also Known As:

Networked: 38 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Methemoglobinemia
2.	Cyanosis
3.	Poisoning
4.	Hemolytic Anemia
5.	Acute Kidney Injury (Acute Renal Failure)

Experts

1.	Baranoski, Gladimir V G: 3 articles (07/2018 - 09/2012)
2.	Kimmel, Bradley W: 2 articles (07/2017 - 09/2012)
3.	Brunker, Sarah E: 1 article (08/2021)
4.	Dergam-Larson, Camila: 1 article (08/2021)
5.	Go, Ronald S: 1 article (08/2021)
6.	Hoyer, James D: 1 article (08/2021)
7.	Nguyen, Phuong L: 1 article (08/2021)
8.	Oliveira, Jennifer L: 1 article (08/2021)
9.	Porter, Tavanna R: 1 article (08/2021)
10.	Rangan, Aruna: 1 article (08/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sulfhemoglobinemia:

1.	Cytochromes b5 (Cytochrome b5)IBA 01/01/1994 - "We studied the incidence of methemoglobinemia, sulfhemoglobinemia and cytochrome b5 reductase deficiency in nine consecutive patients enrolled in a phase II trials using Sulofenur. "
2.	Oxidoreductases (Dehydrogenase)IBA 01/01/1994 - "We studied the incidence of methemoglobinemia, sulfhemoglobinemia and cytochrome b5 reductase deficiency in nine consecutive patients enrolled in a phase II trials using Sulofenur. "
3.	sulofenur (ISCU)IBA 01/01/1994 - "We studied the incidence of methemoglobinemia, sulfhemoglobinemia and cytochrome b5 reductase deficiency in nine consecutive patients enrolled in a phase II trials using Sulofenur. "
4.	Hemoglobins (Hemoglobin)IBA 10/01/1999 - "Whole blood-sample analysis for abnormal hemoglobin pigments established the diagnosis of sulfhemoglobinemia. " 10/01/1999 - "Whole blood-sample analysis for abnormal hemoglobin pigments established the diagnosis of sulfhemoglobinemia. " 07/01/2018 - "On the dysfunctional hemoglobins and cyanosis connection: practical implications for the clinical detection and differentiation of methemoglobinemia and sulfhemoglobinemia." 08/01/2007 - "If it is greater than 5%, the patient's hemoglobin may be abnormal, representing carbon monoxide poisoning, methemoglobinemia, or sulfhemoglobinemia. " 08/19/1966 - "[The oxygen binding capacity of hemoglobin in sulfhemoglobinemia]."
5.	MethemoglobinIBA 01/01/2022 - "Coincidental sulfhemoglobinemia should be considered if the clinical presentation is more severe than the methemoglobin concentration alone would suggest. " 01/01/2021 - "Her arterial blood gas on supplemental high-flow oxygen demonstrated a PaO2 of 413 mm Hg and methemoglobin of 1.2%, but also noted the interference of the co-oximetry with sulfhemoglobinemia. " 07/01/2017 - "Methemoglobinemia and sulfhemoglobinemia are rare, but potentially life threatening, diseases that refer to an abnormal amount of methemoglobin or sulfhemoglobin in the blood, respectively. " 06/01/2005 - "Sulfhemoglobinemia is suspected when a cyanotic patient has normal to near-normal oxygen tension, laboratory reports of elevated methemoglobin, and does not respond to methylene blue therapy. " 09/01/2012 - "Accordingly, in this paper, we investigate the spectral responses of human skin affected by the presence of abnormal amounts of two dysfunctional hemoglobins, methemoglobin and sulfhemoglobin, which are associated with two life-threatening medical conditions, methemoglobinemia and sulfhemoglobinemia, respectively. "
6.	SulfhemoglobinIBA 12/01/2015 - "Sulfhemoglobinemia is a rare disorder characterized by the presence of sulfhemoglobin in the blood. " 01/01/1997 - "A case of sulfhemoglobinemia and emergency measurement of sulfhemoglobin with an OSM3 CO-oximeter." 07/01/2017 - "Methemoglobinemia and sulfhemoglobinemia are rare, but potentially life threatening, diseases that refer to an abnormal amount of methemoglobin or sulfhemoglobin in the blood, respectively. " 09/01/2012 - "Accordingly, in this paper, we investigate the spectral responses of human skin affected by the presence of abnormal amounts of two dysfunctional hemoglobins, methemoglobin and sulfhemoglobin, which are associated with two life-threatening medical conditions, methemoglobinemia and sulfhemoglobinemia, respectively. " 04/01/1998 - "Carbon monoxide-oximetry may falsely identify sulfhemoglobin as methemoglobin; sulfhemoglobinemia should be considered in cases of methemoglobinemia refractory to methylene blue therapy."
7.	Phenazopyridine (Pyridium)FDA LinkGeneric 06/01/2023 - "She was diagnosed with a presumed dyshemoglobinemia and, upon return of send-out labs, was confirmed to have sulfhemoglobinemia attributed to phenazopyridine. " 06/01/2023 - "Sulfhemoglobinemia in a 53-Year-Old With a History of Phenazopyridine Misuse." 06/01/2005 - "This case of sulfhemoglobinemia, which occurred after the patient took phenazopyridine, is considered a probable adverse event according to the Naranjo probability scale." 06/01/2005 - "Phenazopyridine-induced sulfhemoglobinemia." 09/01/1991 - "Phenazopyridine-induced sulfhemoglobinemia: inadvertent rechallenge."
8.	Oxygen (Dioxygen)IBA 01/01/2021 - "Her arterial blood gas on supplemental high-flow oxygen demonstrated a PaO2 of 413 mm Hg and methemoglobin of 1.2%, but also noted the interference of the co-oximetry with sulfhemoglobinemia. " 08/19/1966 - "[The oxygen binding capacity of hemoglobin in sulfhemoglobinemia]." 01/01/2017 - "Sulfhemoglobinemia due to increases in sulfur producing intestinal bacteria led to cyanosis and low oxygen saturations. " 06/01/2005 - "Because the cyanosis did not improve after the patient received oxygen and methylene blue, sulfhemoglobinemia was suspected and confirmed by spectrophotometer analysis. " 06/01/2005 - "Sulfhemoglobinemia is suspected when a cyanotic patient has normal to near-normal oxygen tension, laboratory reports of elevated methemoglobin, and does not respond to methylene blue therapy. "
9.	PhenacetinIBA 04/01/1981 - "The authors report a case of recurrent sulfhemoglobinemia resulting from a chronic abuse of phenacetin. " 01/01/1980 - "Sulfhemoglobinemia was also induced in all groups of animals given phenacetin alone or in combination indicating that toxic doses were administered. " 01/01/1980 - "Sulfhemoglobinemia was also induced in all groups of animals given phenacetin alone or in combination indicating that toxic doses were administered oral LD50's. " 01/01/1980 - "Sulfhemoglobinemia was also induced in all groups of animals given phenacetin alone or in combination indicating that toxic doses were administered oral LD50's. " 10/01/1976 - "Phenacetin-induced sulfhemoglobinemia: report of a case and review of the literature."
10.	Hydroxylamine (Hydroxylamine Hydrochloride)IBA 01/01/1985 - "Acute and chronic exposures to hydroxylamine have caused methemoglobinemia and sulfhemoglobinemia." 08/01/2009 - "International perspective from singapore on "methemoglobinemia and sulfhemoglobinemia in two pediatric patients after ingestion of hydroxylamine sulfate"." 08/01/2009 - "Methemoglobinemia and sulfhemoglobinemia in two pediatric patients after ingestion of hydroxylamine sulfate." 08/01/2009 - "This case report describes two pediatric cases of immediate oxygen desaturation from methemoglobinemia and sulfhemoglobinemia after one sip from a plastic water bottle containing hydroxylamine sulfate used by a relative to clean shoes. "

Therapies and Procedures

1.

Therapeutics 06/01/1995 - "We present a unique case in which a patient on chronic metoclopramide therapy developed sulfhemoglobinemia that resolved with subsequent discontinuation of the drug. " 04/01/2009 - "We report an unusual case of a 45-year-old woman in whom sulfhemoglobinemia from chronic therapy with phenazopyridine was misdiagnosed as due to Raynaud phenomenon and limited scleroderma. " 06/01/2005 - "Sulfhemoglobinemia is suspected when a cyanotic patient has normal to near-normal oxygen tension, laboratory reports of elevated methemoglobin, and does not respond to methylene blue therapy. " 10/01/1999 - "Although N-acetylcysteine alone has not been associated as the cause, we suggest that sulfhemoglobinemia is a potential complication in patients treated with metoclopramide for the nausea that often accompanies oral N-acetylcysteine therapy for acetaminophen toxicity. " 04/01/1998 - "Carbon monoxide-oximetry may falsely identify sulfhemoglobin as methemoglobin; sulfhemoglobinemia should be considered in cases of methemoglobinemia refractory to methylene blue therapy."