Sulfenic Acids

Oxy acids of sulfur with the general formula RSOH, where R is an alkyl or aryl group such as CH3. They are often encountered as esters and halides. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Also Known As:

Networked: 20 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Carroll, Kate S: 3 articles (01/2017 - 09/2009)
2.	Bhatnagar, Aruni: 3 articles (03/2012 - 06/2006)
3.	Ding, Jianan: 2 articles (11/2020 - 01/2020)
4.	Gao, Yinjia: 2 articles (11/2020 - 01/2020)
5.	Mao, Qiulian: 2 articles (11/2020 - 01/2020)
6.	Shi, Haibin: 2 articles (11/2020 - 01/2020)
7.	Wang, Anna: 2 articles (11/2020 - 01/2020)
8.	Xie, Wei: 2 articles (11/2020 - 01/2020)
9.	Ye, Shuyue: 2 articles (11/2020 - 01/2020)
10.	Zhao, Meng: 2 articles (11/2020 - 01/2020)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "Herein, as a proof-of concept, we for the first time report a sulfenic acid-responsive platform on controlled immobilization of probes within mitochondria for prolonged tumor imaging. " 01/01/2020 - "Sulfenic Acid-Mediated on-Site-Specific Immobilization of Mitochondrial-Targeted NIR Fluorescent Probe for Prolonged Tumor Imaging." 01/01/2017 - "In addition to in vitro tracking of the production of protein sulfenic acids in cancer cells under oxidative stress, rSPNs permit real-time PA and fluorescence imaging of protein sulfenic acids in tumors of living mice. " 09/22/2009 - "Applying this approach to several systems, including cancer cell lines, shows it can be used to monitor differences in thiol redox status and reveals a diverse pattern of sulfenic acid modifications across different subtypes of breast tumors. " 11/26/2020 - "Such a nanostructure enables on-site immobilization within tumors under oxidative stress through the specific reaction between CHD and endogenous protein sulfenic acids resulting in enhanced accumulation and retention of gold nanoparticles within tumors, which remarkably improves the sensitivity of CT imaging and the radiotherapeutic efficacy of tumors in living mice. "
2.	Ischemia 02/01/2016 - "Sulfenic Acid Modification of Endothelin B Receptor is Responsible for the Benefit of a Nonsteroidal Mineralocorticoid Receptor Antagonist in Renal Ischemia." 03/01/2017 - "Recent studies suggest that aldosterone-mediated sulfenic acid modification of the endothelin B receptor (ETB) promotes renal injury in an ischemia/reperfusion model through reduced ETB-stimulated nitric oxide production. " 03/01/2012 - "Conditions associated with oxidative or nitrosative stress, such as ischemia-reperfusion, hypertension and tachycardia increase protein glutathiolation via changes in the glutathione redox status (GSH/GSSG) or through the formation of sulfenic acid (SOH) or nitrosated (SNO) cysteine intermediates. "
3.	Inflammation (Inflammations) 01/01/2016 - "This study indicates that inflammation-induced oxidants, and particularly myeloperoxidase-derived species, can modulate the activity of multiple members of the PTP superfamily via oxidation of Cys residues to sulfenic acids. "
4.	Atrial Fibrillation 09/14/2012 - "To investigate how oxidative stress, via redox-sensitive modification of the channel with sulfenic acid, regulates trafficking and expression of Kv1.5. Labeling studies with the sulfenic acid-specific probe DAz and horseradish peroxidase-streptavidin Western blotting demonstrated a global increase in sulfenic acid-modified proteins in human patients with atrial fibrillation, as well as sulfenic acid modification to Kv1.5 in the heart. "
5.	Pathologic Processes 01/01/2017 - "Protein sulfenic acids play a key role in oxidative signal transduction of many biological and pathological processes; however, current chemical tools rely on visible fluorescence signals, limiting their utility to in vitro assays. " 01/01/2021 - "S-sulfenylation (S-sulphenylation, or sulfenic acid) proteins, are special kinds of post-translation modification, which plays an important role in various physiological and pathological processes such as cytokine signaling, transcriptional regulation, and apoptosis. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Gold
3.	triphenylphosphine
4.	1,3-cyclohexanedione
5.	Endothelin B Receptor
6.	Streptavidin
7.	Oxidants (Oxidizing Agents)
8.	Nitric Oxide (Nitrogen Monoxide)
9.	Peroxidase (Myeloperoxidase)
10.	Horseradish Peroxidase

Related Therapies and Procedures

1.	Precision Medicine
2.	Radiotherapy
3.	Lasers (Laser)