Sulfalene (Longum)

Long-acting plasma-bound sulfonamide used for respiratory and urinary tract infections and also for malaria.

Also Known As:

Longum; Kelfizine; Sulfametopyrazine; Sulphalene; Sulphametopyrazine; Sulfamethopyrazine; Sulfamethoxypyrazine; Sulfapyrazinmethoxine; Benzenesulfonamide, 4-amino-N-(3-methoxypyrazinyl)-

Networked: 265 relevant articles (29 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chen, Wei: 6 articles (05/2022 - 03/2019)
2.	Zhang, Hao: 6 articles (05/2022 - 03/2019)
3.	Zhao, Jianxin: 6 articles (05/2022 - 03/2019)
4.	Park, Myeong Soo: 5 articles (01/2021 - 05/2014)
5.	Xu, Gen-Xing: 5 articles (01/2014 - 02/2005)
6.	Fujimori, Minoru: 5 articles (12/2007 - 03/2002)
7.	Taniguchi, Shun'ichiro: 5 articles (12/2007 - 03/2002)
8.	Ji, Geun Eog: 4 articles (01/2021 - 05/2014)
9.	Chen, Chun: 4 articles (01/2020 - 01/2019)
10.	Gao, Xuan: 4 articles (01/2020 - 01/2019)

Related Diseases

1.	Falciparum Malaria (Plasmodium falciparum Malaria) 03/01/1978 - "These findings suggest that acetylator phenotype does not influence the therapeutic response of individuals infected with falciparum malaria to sulfalene or to the combination of sulfalene and pyrimethamine. " 03/01/1978 - "The influence of acetylator phenotype on the response to sulfalene in individuals with chloroquine-resistant falciparum malaria." 01/01/1975 - "The duration of action of the drug Antemal, a combination of Pyrimethamine and Sulfametopyrazine, was eveluated in Bobo-Dioulasso, Upper Volta, West Africa, and endemic zone for Plasmodium falciparum malaria. " 11/01/1971 - "Treatment of falciparum malaria with sulfalene and trimethoprim." 07/01/1971 - "Treatment of acute falciparum malaria from Vietnam with trimethoprim and sulfalene."
2.	Constipation 01/01/2023 - "longum BB536 supplementation is safe and partially effective for improving chronic constipation in elderly individuals." 01/01/2023 - "longum CLA8013 improved the bowel movements of constipation-prone healthy individuals and confirmed that there were no relevant safety issues." 05/10/2022 - "longum relieved constipation by regulating the intestinal barrier in constipated mice." 05/10/2022 - "longum) relieved constipation, which indicated that bifidobacteria had inter-species differences in relieving constipation. " 07/01/2007 - "longum and the placebo group (mean 7.1, 95% CI 2.3 - 11.9, p=0.004) and between the B.lactis group and the placebo (mean 6.7, 95% CI 2.5 - 10.9, p = 0.002) were significant even when diarrhoea and constipation in the 3 months prior to the study were used as covariates. "
3.	Neoplasms (Cancer) 02/20/2023 - "longum 420/2656 combination further accelerated antitumor activity that relies on WT1-specific CTLs in the tumor compared with B. " 01/01/2022 - "longum-Endo significantly decreased tumor formation rate, tumor number, and tumor size. " 01/01/2020 - "longum followed by that of PFH/BL-NPs can enhance the imaging of solid tumors and effectively improve the efficiency of HIFU treatment of solid tumors, providing a basis for further clinical work." 01/01/2020 - "longum followed by that of PFH/BL-NPs not only enhanced the ability of PFH/BL-NPs to target solid tumors (small animal live imaging), but also increased the retention time of PFH/BL-NPs in the tumor (frozen slices), enhancing the effect of the HIFU synergist. " 01/01/2020 - "longum) which can colonize selectively in hypoxic regions of the animal body was successfully localized and shown to proliferate in the hypoxic zone of tumor tissue, overcoming the above disadvantages. "
4.	Inflammation (Inflammations) 06/06/2023 - "longum DD98 significantly relieved the intestinal symptoms of IBS mice and reduced intestinal permeability and inflammation. " 01/29/2020 - "longum R0175 exerted liver-protective effects by affecting the intestinal microbiota and fecal metabolites and by inhibiting inflammation. " 01/01/2023 - "longum R0175 could reduce oxidative damage, inflammation and hepatocyte death by activating the Nrf2 pathway. " 01/01/2021 - "Viability Status-Dependent Effect of Bifidobacterium longum ssp. longum CCM 7952 on Prevention of Allergic Inflammation in Mouse Model." 05/01/2010 - "longum AH1206 protected against airway inflammation in OVA-sensitized animals and B. "
5.	Colitis 01/18/2023 - "longum CCFM1206 and BSE could ameliorate colitis symptoms, relieve colonic inflammatory reactions and oxidative stress, and protect the intestinal barrier in DSS-induced mice. " 01/18/2023 - "longum CCFM1206 were applied to explore the effects on DSS-induced colitis. " 01/01/2022 - "longum CECT 7894 modified the composition and structure of the gut microbiota community in DSS-induced colitis mice. " 01/01/2022 - "longum DD98 showed a stronger effect on relieving the aforementioned symptoms caused by DSS-induced colitis. " 04/26/2021 - "longum strains was performed on the basis of 936 core genes; among these, four strains from different branches of the phylogenetic tree were selected for an evaluation of anti-inflammatory and immune modulatory activities in a DSS-induced colitis mouse model. "

Related Drugs and Biologics

1.	Pyrimethamine (Daraprim)
2.	Artesunate
3.	Amodiaquine (Camoquin)
4.	Dextran Sulfate
5.	Trimethoprim (Proloprim)
6.	Lumefantrine Drug Combination Artemether (Coartem)
7.	Chloroquine (Aralen)
8.	Sulfamethoxazole
9.	Tetracycline (Achromycin)
10.	Ointments (Pastes)

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration
3.	Immunotherapy
4.	Aftercare (After-Treatment)
5.	Myocutaneous Flap