|2.||Brain Injuries (Brain Injury)
|5.||Intracranial Aneurysm (Cerebral Aneurysm)
|1.||Zhang, John H: 67 articles (01/2016 - 02/2002)|
|2.||Mayer, Stephan A: 52 articles (10/2015 - 01/2002)|
|3.||Macdonald, R Loch: 46 articles (10/2015 - 05/2002)|
|4.||Connolly, E Sander: 44 articles (02/2015 - 01/2002)|
|5.||Suzuki, Hidenori: 36 articles (01/2016 - 12/2003)|
|6.||Kwan, Aij-Lie: 31 articles (12/2015 - 02/2002)|
|7.||Lin, Chih-Lung: 25 articles (06/2015 - 02/2002)|
|8.||Chen, Gang: 23 articles (12/2015 - 01/2009)|
|9.||Badjatia, Neeraj: 23 articles (02/2015 - 01/2004)|
|10.||Claassen, Jan: 22 articles (10/2015 - 07/2006)|
|1.||Nimodipine (Modus)FDA LinkGeneric
04/01/1988 - "Nimodipine treatment was associated with a significantly better outcome (p less than 0.001): 21 (29.2%) of 72 nimodipine-treated patients had a good outcome at 3 months after subarachnoid hemorrhage (SAH) compared to eight (9.8%) of 82 placebo-treated patients. "
01/01/2014 - "Nimodipine is well characterized for the management of SAH (subarachnoid hemorrhage) and has been shown to promote a better outcome and less DIND (delayed ischemic neurological deficits). "
03/01/2009 - "In subarachnoid hemorrhage nimodipine was found effective in preventing vasospasm and thus secondary ischemic cerebral damage. "
06/01/2004 - "Intra-arterial nimodipine is effective and safe for the treatment of symptomatic vasospasm after subarachnoid hemorrhage. "
06/01/2011 - "This study evaluated the efficacy of intra-arterial nimodipine infusion for symptomatic vasospasm in patients with aneurysmal subarachnoid hemorrhage (aSAH). "
|2.||Tissue Plasminogen Activator (Alteplase)FDA Link
11/01/2004 - "The efficacy of intraoperative cisternal irrigation using tissue-type plasminogen activator (tPA) combined with continuous cisternal drainage was assessed for the prevention of symptomatic vasospasm in patients with aneurysmal subarachnoid hemorrhage (SAH). "
10/01/2014 - "Intraventricular tissue plasminogen activator in subarachnoid hemorrhage patients: a prospective, randomized, placebo-controlled pilot trial."
06/01/1992 - "Single intracisternal bolus of recombinant tissue plasminogen activator in patients with aneurysmal subarachnoid hemorrhage: preliminary assessment of efficacy and safety in an open clinical study."
08/01/1991 - "Phase I trial of tissue plasminogen activator for the prevention of vasospasm in patients with aneurysmal subarachnoid hemorrhage."
06/01/1991 - "In this study, we investigated the ability of a single bolus injection of tissue plasminogen activator to prevent platelet accumulation in cerebral vessels after subarachnoid hemorrhage. "
01/01/1995 - "Papaverine was effective in dilating narrowed arteries in most patients with symptomatic vasospasm caused by subarachnoid hemorrhage. "
02/01/2001 - "It remains controversial whether the intra-arterial administration of papaverine (IAP) is effective in reversing vasospasm-associated cerebral hypoperfusion after aneurysmal subarachnoid hemorrhage. "
04/01/1998 - "We described the techniques and efficacy of intra-arterial papaverine hydrochloride infusion (IA-PAP) for symptomatic vasospasm due to aneurysmal subarachnoid hemorrhage based on our experience and review of the literature. "
11/01/1995 - "This study examined the relationship between papaverine-sensitive and -insensitive components of vasospasm, arterial contractility and compliance, and time after subarachnoid hemorrhage (SAH) in dogs. "
01/01/1995 - "Effect of intra-arterial papaverine on cerebral blood flow in vasospasm after subarachnoid hemorrhage: A study using single-photon emission computed tomography."
06/01/1999 - "To test the safety and efficacy of high-dose (15 mg/kg/day) tirilazad mesylate in women suffering from aneurysmal subarachnoid hemorrhage (SAH), a prospective randomized, double-blind, vehicle-controlled trial (parallel to the one conducted in Europe, Australia, New Zealand, and South Africa) was performed at 65 North American neurosurgical centers. "
10/01/1997 - "These results suggest that gender differences do not significantly effect the blood-brain barrier protective efficacy of tirilazad following subarachnoid hemorrhage in the rat."
10/01/1997 - "The purpose of the present study was to compare the efficacy of tirilazad in attenuating early post-subarachnoid hemorrhage-induced blood-brain barrier damage in the rat, a species in which single-dose metabolism of the drug is comparable between males and females. "
03/01/1997 - "To test the safety and efficacy of tirilazad mesylate, a nonglucocorticoid 21-aminosteroid, in improving the outcome of patients with aneurysmal subarachnoid hemorrhage (SAH), 902 patients were enrolled in a prospective randomized, double-blind, vehicle-controlled trial at 54 North American neurosurgical centers. "
01/01/2013 - "The approach of Bayesian neural networks with fuzzy logic inferences was applied to data from five trials of Tirilazad for aneurysmal subarachnoid hemorrhage (3551 patients). "
|5.||Nicardipine (Dagan)FDA LinkGeneric
04/01/2009 - "Although intraarterial nicardipine appears to be promising in aneurysmal subarachnoid hemorrhage, well-designed studies are needed in this setting before its use can be routinely recommended."
01/01/1989 - "The efficacy of intravenous nicardipine in the prevention of vasospasm after subarachnoid hemorrhage has been investigated in a dose escalation study in 67 patients admitted within 1 week of subarachnoid hemorrhage. "
06/01/2012 - "The purpose of the study is to determine the effectiveness and safety of nicardipine infusion for controlling blood pressure in patients with subarachnoid hemorrhage (SAH). "
05/01/1994 - "A randomized trial of two doses of nicardipine in aneurysmal subarachnoid hemorrhage. "
04/01/1993 - "A randomized trial of nicardipine in subarachnoid hemorrhage: angiographic and transcranial Doppler ultrasound results. "
|6.||Simvastatin (Zocor)FDA LinkGeneric
02/01/2015 - "We hypothesized that a high dose of 80 mg of simvastatin daily for 3 weeks would reduce the incidence of delayed ischemic deficits after subarachnoid hemorrhage compared with a lower dose (40 mg of simvastatin daily) and lead to improved clinical outcomes. "
12/01/2011 - "Simvastatin administration ameliorates neurobehavioral consequences of subarachnoid hemorrhage in the rat."
11/15/2015 - "The current study does not support that acute simvastatin treatment improves cognitive outcome after aneurysmal subarachnoid hemorrhage."
05/01/2015 - "We highlight the results from the simvastatin in aneurysmal subarachnoid hemorrhage study (STASH) (Kirkpatrick et al. Lancet Neurol 2014;13:666-75) which unfortunately did not demonstrate a benefit of simvastatin on outcome in patients with aneurysmal subarachnoid hemorrhage. "
05/01/2013 - "This will be the first study to clarify whether high-dose simvastatin is better than normal-dose simvastatin for patients with acute aneurysmal subarachnoid hemorrhage in terms of neurological outcomes and cost-effectiveness. "
|7.||glucuronyl glucosamine glycan sulfate (Vessel)IBA
11/01/2012 - "Cerebral vasomotor reactivity, however, is significantly improved after long-term statin administration in most patients with severe small vessel disease, aneurysmal subarachnoid hemorrhage, or impaired baseline CA."
03/01/2013 - "High-resolution magnetic resonance vessel wall imaging (MR-VWI) is increasingly used to study steno-occlusive cerebrovascular disease, but has not yet been applied to patients with aneurysmal subarachnoid hemorrhage (SAH). "
04/01/2001 - "The aim of this study was to identify whether interrupted and uninterrupted vessel occlusion differs with regard to changes in brain tissue and cerebral hemodynamics after subarachnoid hemorrhage (SAH). "
05/01/1998 - "To test the ability of these indices to evaluate a decrease in vessel diameter, signals from 41 sites on 23 arteries were obtained from patients who underwent both TCD and angiographic studies on two separate occasions after the occurrence of subarachnoid hemorrhage. "
11/01/2015 - "Furthermore, interactions between the device and the vessel walls and contrast intoxication may also be related to ICH, which includes the occurrence of subarachnoid hemorrhage after endovascular therapy. "
|8.||Biological Markers (Surrogate Marker)IBA
01/01/2012 - "We performed a review of studies conducted over the past 2 decades summarizing the science to date and the evolution of CSF biomarkers in subarachnoid hemorrhage (SAH). "
02/01/2010 - "The first study was a project funded by the National Institutes of Health designed to identify biomarkers of vasospasm in persons (n = 496) with aneurysmal subarachnoid hemorrhage who presented to the neurovascular intensive care unit (National Institute of Nursing Research, R01 NR004339). "
01/15/2010 - "The aim of this study is to determine effective biochemical markers and optimal sampling timing for prediction of neurological prognosis in post-surgical aneurysmal subarachnoid hemorrhage (SAH) patients. "
12/16/2015 - "Therefore, this Viewpoint discusses recent findings suggesting that monitoring biomarkers of brain energy metabolism at the level of individuals can be used to predict the outcomes of subarachnoid hemorrhage patients. "
12/16/2015 - "Clinical Neurochemistry of Subarachnoid Hemorrhage: Toward Predicting Individual Outcomes via Biomarkers of Brain Energy Metabolism."
|9.||Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA
01/01/2011 - "Reduced endothelial nitric oxide synthase (eNOS) function has been linked to secondary complications of subarachnoid hemorrhage (SAH). "
01/01/2011 - "Uncoupling of endothelial nitric oxide synthase after experimental subarachnoid hemorrhage."
07/01/2009 - "Severe subarachnoid hemorrhage (SAH) induces dysfunction of endothelial nitric oxide synthase (eNOS), resulting in severe vasospasm. "
07/01/2009 - "Modification of endothelial nitric oxide synthase through AMPK after experimental subarachnoid hemorrhage."
07/01/2009 - "Endothelial nitric oxide synthase tagging single nucleotide polymorphisms and recovery from aneurysmal subarachnoid hemorrhage."
|10.||Calcitonin Gene-Related PeptideIBA
10/27/2000 - "We sought to determine whether adenovirus-mediated gene transfer in vivo of calcitonin gene-related peptide (CGRP), a potent vasodilator, ameliorates cerebral vasoconstriction after experimental subarachnoid hemorrhage (SAH). "
11/01/1991 - "The authors propose that the marked decrease of calcitonin gene-related peptide immunoreactivity in the perivascular nerves, observed after experimental subarachnoid hemorrhage, is due to compensatory secretion of the peptide."
10/27/2000 - "Gene transfer of calcitonin gene-related peptide prevents vasoconstriction after subarachnoid hemorrhage."
09/15/1995 - "The neuroprotective effect of calcitonin gene-related peptide following subarachnoid hemorrhage. "
09/01/1995 - "Effects of subarachnoid hemorrhage on vascular responses to calcitonin gene-related peptide and its related second messengers."
11/01/1989 - "The overall results of this series indicate that in selected cases percutaneous balloon angioplasty can offer marked improvement to patients with ischemic deficits due to vasospasm following subarachnoid hemorrhage."
10/15/1998 - "Safety and efficacy of transluminal balloon angioplasty in the prevention of vasospasm in patients with Fisher Grade 3 subarachnoid hemorrhage: a pilot study."
07/01/2011 - "To report our experience with a large series of balloon angioplasty for distal VSP refractory to medical therapy in patients with aneurysmal subarachnoid hemorrhage. "
07/01/2011 - "Transluminal balloon angioplasty for symptomatic distal vasospasm refractory to medical therapy in patients with aneurysmal subarachnoid hemorrhage."
01/01/2011 - "Cerebral artery restenosis following transluminal balloon angioplasty for vasospasm after subarachnoid hemorrhage."
05/01/2013 - "Lastly, the use of antithrombotic therapy in the setting of subarachnoid hemorrhage, dissection, and stent placement is discussed."
03/01/2013 - "The use of an intracranial stent in the setting of subarachnoid hemorrhage (SAH) is risky due to the need for antiplatelet therapy. "
12/01/2012 - "Stent-assisted coil embolization of subarachnoid hemorrhage with bilateral VADAs for both sides is a reasonable treatment because it prevents rebleeding and preserves bilateral vertebral arteries without increasing hemodynamic stress. "
10/01/2012 - "This report is of a case of intra-cranial carotid artery dissection treated by a reconstructive endovascular approach, with deployment of a flow-diverter stent, for the management of an associated subarachnoid hemorrhage. "
06/01/2012 - "Stent-assisted coiling in the setting of subarachnoid hemorrhage remains controversial. "
07/01/2002 - "Eight patients with transcranial Doppler verified vasospasm after subarachnoid hemorrhage were investigated with global (two-dimensional (133)Xenon) and regional (three-dimensional (99 m)Tc-HMPAO) cerebral blood flow (CBF) measurements, before and after 1/iso- and 2/hypervolemic hemodilution. "
12/01/1997 - "These data support a hypothesis that hemodilution decreases hypoperfusion and neuronal death after subarachnoid hemorrhage. "
12/01/1993 - "[Hypervolemic hemodilution therapy for clinical vasospasm after aneurysmal subarachnoid hemorrhage]."
11/01/1990 - "Sustained increased cerebral blood flow with prophylactic hypertensive hypervolemic hemodilution ("triple-H" therapy) after subarachnoid hemorrhage."
11/01/1989 - "Hypervolemic hemodilution: a new approach to subarachnoid hemorrhage."
|4.||Surgical Instruments (Clip)
10/01/2012 - "It has been demonstrated that the presence of subarachnoid hemorrhage, specific anatomic locations, and large size may predispose to improper clip placement. "
12/01/2007 - "Evaluation of olfactory nerve function after aneurysmal subarachnoid hemorrhage and clip occlusion."
11/01/2002 - "Neurosurgical clip application is the standard method used to prevent rebleeding in patients with aneurysmal subarachnoid hemorrhage (SAH). "
11/01/2002 - "Effectiveness of neurosurgical clip application in patients with aneurysmal subarachnoid hemorrhage."
03/01/2008 - "The authors calculate the life expectancy of patients following a subarachnoid hemorrhage (SAH) and compare the life expectancy of those who underwent coil embolization with those who underwent clip ligation in the ISAT cohort. "
|5.||Angioplasty (Angioplasty, Transluminal)
10/01/1990 - "Cerebral angioplasty: a new treatment for vasospasm secondary to subarachnoid hemorrhage."
05/01/1997 - "In this study the authors have examined the effects of transluminal angioplasty on cerebral blood flow (CBF) in the management of intractable vasospasm following aneurysmal subarachnoid hemorrhage (SAH). "
06/01/1995 - "Light and electron microscopy were used to study morphological changes in cerebral arteries after percutaneous transluminal angioplasty (PTA) for vasospasm in two patients with aneurysmal subarachnoid hemorrhage. "
01/01/2011 - "the frequency and predictors of recurrent symptomatic and angiographic vasospasm after angioplasty or intra-arterial chemical vasodilatation (IACV) in patients with subarachnoid hemorrhage (SAH) are not well characterized. "
04/01/2010 - "Extravasating contrast material on angiography following carotid angioplasty and stenting: not necessarily subarachnoid hemorrhage."