|1.||Fry, Christopher H: 1 article (05/2006)|
|2.||Wu, Changhao: 1 article (05/2006)|
|3.||Besarani, Dler: 1 article (05/2006)|
|4.||Filigenzi, Michael S: 1 article (04/2004)|
|5.||Woods, Leslie W: 1 article (04/2004)|
|6.||Puschner, Birgit: 1 article (04/2004)|
|7.||Booth, Marcia C: 1 article (04/2004)|
|8.||Tor, Elizabeth R: 1 article (04/2004)|
|9.||Chen, Y J: 1 article (05/2001)|
|10.||Chiou, C W: 1 article (05/2001)|
05/01/1970 - "1. The ED50 of acetyl strophanthidin for producing ventricular arrhythmias in normal dogs was 54.5 mug/kg intravenously.2. Doses up to and including those which caused ventricular tachycardia did not produce either atrial arrhythmias or significant aberration of A-V conduction.3. Although the classic digitalis-induced rate and e.c.g. "
05/01/2001 - "These findings suggest that L-arginine was effective in treating strophanthidin-induced ventricular tachycardia in vivo and that the underlying mechanism is through a NO pathway."
01/01/1999 - "This study demonstrated that trilinolein was not effective in terminating or preventing strophanthidin-induced ventricular tachycardia. "
05/01/2001 - "In experiment 2, after strophanthidin-induced ventricular tachycardia, dogs (n = 7) received 200 mg/kg L-arginine. "
05/01/2001 - "Effect of nitric oxide on strophanthidin-induced ventricular tachycardia."
09/01/1963 - "EFFECT OF EXPERIMENTAL CONGESTIVE HEART FAILURE AND ACETYL STROPHANTHIDIN ON MYOCARDIAL ELECTROLYTE AND WATER CONTENT."
08/01/1957 - " VIII. Effects of acetyl strophanthidin on pulmonary circulation in patients with cardiac failure and mitral stenosis."
05/01/1992 - "We evaluated the efficacy of K-strophanthidin and digoxin in 20 patients with stable, severe congestive heart failure. "
02/01/1959 - "Myocardial response to acetyl strophanthidin in congestive heart failure; a study of electrolytes and carbohydrate substrates."
01/01/1995 - "The major differences in the electro-mechanical actions of strophanthidin in tilapia versus human heart tissues are the smaller positive inotropy and the proneness to contracture in tilapia heart at 37 degrees C."
02/18/1992 - "Strophanthidin (1 microM) progressively increases aNai whereas increases and then decreases contractile force, induces contracture ('mechanical toxicity') and arrhythmias ('electrical toxicity'). "
10/01/1986 - "This would be consistent with the notion that contracture tension is determined by an electrogenic Na/Ca exchange across the cell membrane with a coupling ratio approaching 3 Na+/Ca2+. Exposure of the muscle to strophanthidin reduces the size of the hyperpolarizing pulse required to relax completely the low-Na contracture. "
10/01/1986 - "Contractures induced by treating resting muscles with 5 X 10(-5) M strophanthidin at 30 degrees C exhibited pronounced tension noise. "
12/01/1983 - "Na removal contributes more than depolarization to the effects of a Na-free, K-containing solution on the contracture and rise of [Ca2+]i. Increasing intracellular Na concentration [( Na+]i), by exposure to strophanthidin (10 mumol/l), increased the magnitude of both the contracture and [Ca2+]i in 0 Na(K) solutions. "
|4.||Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
03/15/1990 - "Assessment of the hemodynamic response to acetyl-strophanthidin by Doppler echocardiography in normal subjects and in those with coronary artery disease or idiopathic dilated cardiomyopathy."
05/01/1992 - "[Better efficacy of K-strophanthidin versus digoxin in subjects with dilated cardiomyopathy and chronic heart insufficiency]."
|5.||Cardiac Arrhythmias (Arrythmia)
05/01/2001 - "The purpose of this study was to evaluate the effects of NO on ventricular arrhythmia induced by strophanthidin in guinea pigs and dogs. "
05/01/1984 - "Thus no correlation was observed between the positive inotropic and antiarrhythmic action of acetyl-strophanthidin on ventricular arrhythmia and LVEF. "
05/01/1984 - "Acetyl-strophanthidin suppressed ventricular arrhythmia in 17 patients, but LVEF increased in only six of these patients (57% to 67%), while it was unaltered in 11 patients (28% to 30%). "
08/01/1969 - "Another group received a dose of acetyl strophanthidin which was nontoxic in controls, but which resulted in a ventricular arrhythmia in six of seven animals on antibiotic treatment. "
10/01/1967 - "This view is supported by the myocardial loss of K(+) and arrhythmia induced in normal dogs by strophanthidin and by the fact that pharmacologic regulation of K(+) loss is associated with correction of the arrhythmia, despite persistence of low blood flow."
|5.||Caffeine (No Doz)
|7.||Adenosine Triphosphatases (ATPase)
|8.||Ouabain (G Strophanthin)
|9.||Urethane (Ethyl Carbamate)