Streptonigrin (Nigrin)

Complex cytotoxic antibiotic obtained from Streptomyces flocculus or S. rufochronmogenus. It is used in advanced carcinoma and causes leukopenia.

Also Known As:

Nigrin; Rufocromomycin; Brunemycin; NSC-45383; NSC 45383; NSC45383; Bruneomycin; 2-Pyridinecarboxylic acid, 5-amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolinyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methyl-

Networked: 88 relevant articles (1 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bolzán, Alejandro D: 3 articles (02/2014 - 01/2003)
2.	Ge, Hui: 2 articles (04/2019 - 10/2017)
3.	Tao, Liang: 2 articles (04/2019 - 10/2017)
4.	Wang, Qin: 2 articles (04/2019 - 10/2017)
5.	Wang, Xiyan: 2 articles (04/2019 - 10/2017)
6.	Cullen, Joseph J: 2 articles (07/2017 - 08/2005)
7.	Lewis, Anne M: 2 articles (07/2017 - 08/2005)
8.	Oberley, Larry W: 2 articles (07/2017 - 08/2005)
9.	Ough, Matthew: 2 articles (07/2017 - 08/2005)
10.	Tsao, Ming-Sound: 2 articles (07/2017 - 08/2005)

Related Diseases

1.	Neoplasms (Cancer) 04/04/2019 - "The effect of Cx32 overexpression on the streptonigrin (SN)-induced tumor growth suppression and apoptosis was assessed in nude mice. " 11/19/2018 - "In addition, a single dose of streptonigrin (0.2 mg/kg) showed marked anti-tumor effects in a preclinical RCC model by stabilizing p53. " 11/19/2018 - "The anti-cancer effects of streptonigrin on RCC cell lines were demonstrated in cell proliferation and cell death assays. " 02/15/2014 - "Streptonigrin which possesses both anti-tumor and anti-bacterial activity was later identified as a highly potent PAD4 inhibitor. " 12/01/1963 - "CLINICAL EFFECTS OF PROLONGED (CONTINUOUS) INFUSION OF STREPTONIGRIN (NSC-45383) IN ADVANCED CANCER."
2.	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/01/1968 - "[Reticulosarcoma of the fronto-ortibal region treated by rufocromomycin with radiotherapy (1 case)]." 02/01/1968 - "[Study of combined action of bruneomycin and prednisolone on the development of mouse lymphosarcoma (strain LIO-1)]." 01/01/1978 - "A randomized therapeutic trial of three induction regimens for patients with lymphosarcoma and reticulum-cell sarcoma was conducted by the Cancer and Leukemia Group B (CALGB) (formerly Acute Leukemia Group B.) Addition of streptonigrin, but not cyclophosphamide, to the combination of vincristine and prednisone improved the complete remission rate achieved after a 42-day induction program. "
3.	Leukemia 05/01/1980 - "[Therapeutic results of chronic leukemia and other myeloproliferative syndrome with streptonigrin in 92 cases (author's transl)]." 01/01/1969 - "[Experience of use of bruneomycin in leukemia]." 06/01/1976 - "Therapeutic activity of pretazettine, a narcissus alkaloid on Rauscher leukemia: comparison with tazettine and streptonigrin." 06/01/1976 - "The therapeutic activity of narcissus alkaloid pretazettine HC1 (PTZ) on established Rauscher leukemia has been demonstrated and compared with the isomer tazettine (TZ) and an antibiotic, streptonigrin (SN). " 01/01/1978 - "A randomized therapeutic trial of three induction regimens for patients with lymphosarcoma and reticulum-cell sarcoma was conducted by the Cancer and Leukemia Group B (CALGB) (formerly Acute Leukemia Group B.) Addition of streptonigrin, but not cyclophosphamide, to the combination of vincristine and prednisone improved the complete remission rate achieved after a 42-day induction program. "
4.	Chromosome Aberrations (Chromosome Abnormalities) 06/01/1981 - "In the new data presented in this study, none of the 90 control blastocysts karyotyped had consistent structural chromosome abnormalities while 13 of 278 from female rabbits treated with streptonigrin (NSC-45383) before conception did. " 06/01/1984 - "The frequency of consistent structural chromosome aberrations was determined for 108 fetuses (day 14 of gestation) from 20 female rabbits treated before conception with 90 micrograms/kg of streptonigrin (NSC-45383). " 01/01/1981 - "Factors affecting the sensitivity of rabbit lymphoid and bone marrow cells to Streptonigrin-induced chromosome aberrations." 05/01/1964 - "THE PRODUCTION OF CHROMOSOMAL ABERRATIONS BY STREPTONIGRIN IN VICIA FABA." 02/01/2014 - "We analyzed the chromosomal aberrations involving telomeres in the progeny of mammalian cells exposed to the radiomimetic compound streptonigrin (SN) in order to determine if this antineoplastic drug induces long-term telomere instability. "
5.	Lymphoma (Lymphomas) 04/23/2009 - "As pro-B-cell lymphoma is caused by a translocation between chromosomes 12 and 15, we tested fibroblasts for DNA repair capacity, and found that p53-mutant fibroblasts are more sensitive to streptonigrin and paraquat when deleted for Ku80 as compared with Ku70. " 06/01/1969 - "Comparison of chlorambucil and streptonigrin (NSC-45383) in the treatment of malignant lymphomas." 10/01/1966 - "Treatment of malignant lymphomas with methyl ester of streptonigrin (NSC 45384)." 05/01/1965 - "METHYL ESTER OF STREPTONIGRIN (NSC-45384) IN TREATMENT OF MALIGNANT LYMPHOMA." 07/01/1983 - "In a randomized, prospective trial from 1974-1978, 73 patients with non-Hodgkin's lymphomas in clinical Stage I or II were treated with extended field radiotherapy alone (RT) or RT plus adjuvant chemotherapy with vincristine, streptonigrin, cyclophosphamide and prednisone (RT + CT). "

Related Drugs and Biologics

1.	Vincristine (Oncovin)
2.	Prednisone (Sone)
3.	Cyclophosphamide (Cytoxan)
4.	Daunorubicin (Cerubidine)
5.	Mutagens
6.	Prednisolone (Predate)
7.	Cisplatin (Platino)
8.	Anti-Bacterial Agents (Antibiotics)
9.	Antineoplastic Agents (Antineoplastics)
10.	Olivomycins

Related Therapies and Procedures

1.	Radiotherapy
2.	Adjuvant Chemotherapy
3.	Aftercare (After-Treatment)
4.	Therapeutics
5.	Intravenous Infusions