Aphthous Stomatitis (Aphthous Ulcer)

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576 relevant articles (59 outcomes, 71 trials/studies) found for this Disease

Description: A recurrent disease of the oral mucosa of unknown etiology. It is characterized by small white ulcerative lesions, single or multiple, round or oval. Two to eight crops of lesions occur per year, lasting for 7 to 14 days and then heal without scarring. (From Jablonski's Dictionary of Dentistry, 1992, p742)

Also Known As:

Aphthous Ulcer; Canker Sore; Aphthous Ulcers; Canker Sores; Aphthae; Stomatitis, Aphthous; Aphthous Stomatitides; Sore, Canker; Sores, Canker; Stomatitides, Aphthous; Ulcers, Aphthous; Periadenitis Mucosa Necrotica Recurrens; Ulcer, Aphthous

Relationship Network

Disease Context: Research Results

Stomatognathic Diseases: 250

Mouth Diseases: 55

Stomatitis: 1426

Aphthous Stomatitis: 576

Related Diseases

1.	Pain (Aches)
2.	Erythema Nodosum
3.	Ulcer
4.	HIV Infections (HIV Infection)
5.	Syndrome

Experts

1.	Thornhill, M H: 4 articles (11/2003 - 05/2002)
2.	Gomez, Ricardo Santiago: 3 articles (03/2007 - 04/2003)
3.	Bazrafshani, M R: 3 articles (11/2003 - 08/2002)
4.	Ollier, W E R: 3 articles (11/2003 - 08/2002)
5.	Hajeer, A H: 3 articles (11/2003 - 08/2002)
6.	Albanidou-Farmaki, Eleni: 2 articles (04/2008 - 06/2007)
7.	Epstein, Joel: 2 articles (01/2008 - 01/2007)
8.	Gorsky, Meir: 2 articles (01/2008 - 01/2007)
9.	Correia-Silva, Jeane de Fátima: 2 articles (03/2007 - 09/2005)
10.	Kalapothakis, Evanguedes: 2 articles (09/2005 - 04/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Aphthous Stomatitis:

1.	Thalidomide (Thalomid)FDA Link 07/01/1990 - "Most of the patients who did not achieve a complete remission had a dramatic improvement with regard to the number of aphthae when they were receiving thalidomide" 09/01/1993 - "A child affected by giant recurrent aphthous ulcers was treated successfully over the long term with thalidomide, with no adverse reactions or reduction of therapeutic efficacy" 09/01/1987 - "A 48-year-old man with a 27-year history of debilitating recurrent aphthous stomatitis major and pustular skin lesions was treated successfully with thalidomide" 07/01/1990 - "We concluded that thalidomide in a dosage of 100 mg/d is an effective treatment of severe aphthous stomatitis but is not without some risk." 01/01/1995 - "Randomized placebo-controlled, double-blinded studies are needed to evaluate the efficacy of thalidomide in HIV-positive persons with aphthous ulcers" Order ALL the reference details at left...
2.	amlexanox (Aphthasol)FDA Link 11/01/1997 - "Five percent Amlexanox oral paste is a novel treatment for aphthous ulcers" 11/01/1997 - "Amlexanox oral paste: a novel treatment that accelerates the healing of aphthous ulcers." 02/01/1997 - "5% amlexanox oral paste, a new treatment for recurrent minor aphthous ulcers: II. Pharmacokinetics and demonstration of clinical safety." 02/01/2006 - "BACKGROUND: The study was designed to determine the efficacy of OraDisc (active component 2 mg amlexanox) on the prevention of aphthous ulcers treated at the prodromal stage" 02/01/1997 - "5% Amlexanox oral paste (Aphthasol) was studied in four vehicle-controlled, randomized, double-blind, parallel group, multicenter, clinical studies involving 1335 subjects who had 1 to 3 aphthous ulcers less than 48 hours old at enrollment" Order ALL the reference details at left...
3.	Levamisole (Decaris)FDA Link 01/01/1978 - "A randomized double-blind study was designed to evaluate the safety and efficacy of levamisole in the treatment of recurrent aphthous stomatitis (RAS)" 03/01/1978 - "A randomized double-blind trial of levamisole in the therapy of recurrent aphthous stomatitis." 03/01/1978 - "The results obtained confirm previous studies that levamisole has a beneficial effect on the symptoms of recurrent aphthous stomatitis and is well-tolerated." 03/01/1978 - "In a pilot study as well as in a double-blind placebo-controlled study, 21 patients suffering from recurrent aphthous stomatitis were treated with the immunotherapeutic agent, levamisole" 01/01/1978 - "It is concluded that levamisole, in this study protocol, had no effect on the incidence or severity of aphthous ulcers." Order ALL the reference details at left...
4.	irsogladineIBA 12/01/2001 - "A case of idiopathic relapsing aphthous stomatitis which was effectively treated by irsogladine maleate]" 02/01/1999 - "Irsogladine maleate, which reinforces gap junctional intercellular communication in vitro, was effective for the treatment of transient and relapsing aphthous stomatitis, as well as symptomatic and drug-induced aphthous stomatitis" 01/01/2008 - "The improvement in gap-junctional intercellular communication by irsogladine may contribute to the treatment of aphthous stomatitis in patients with BD" 01/01/2008 - "The dose of irsogladine in this patient was then increased to 4 mg/day, after which aphthous stomatitis resolved" 01/01/2008 - "In case 8, aphthous stomatitis reappeared 2 months after administration of irsogladine 2 mg/day" Order ALL the reference details at left...
5.	TabletsIBA 08/15/1958 - "The treatment of aphthous stomatitis with Lactobacillus tablets." 10/01/1984 - "Clinical evaluation of sebidin tablets in the treatment of chronic recurrent aphthous stomatitis and selected cases of stomatitis]" 10/01/2006 - "100 cases of recurrent aphthous ulcer (RAU) were randomly divided into two groups, 55 cases in the experimental group who were given traditional Chinese medicine Zhong tong'an capsules combined with dexamethasone tablets, while 45 cases in the control group who were given dexamethasone tablets alone" 03/01/1975 - "In a random double blind trial with crossover on 24 patients with recurrent aphthous ulcers (RAU) cromoglycic acid tablets significantly reduced the pain experienced when compared with placebo but did not reduce the number of days with oral ulceration present" 10/01/2006 - "CONCLUSIONS: Amlexanox oral adhesive tablets are effective and safe in reducing aphthous ulcer pain and lesion size, as well as erythema and exudation in this Chinese cohort." Order ALL the reference details at left...
6.	Gluten (Glutens)IBA 01/01/2006 - "All symptoms related to aphthous stomatitis responded well to a gluten-free diet" 03/01/1980 - "In the group, two patients were found to have coeliac disease and their recurrent aphthae cleared soon after starting a gluten free diet" 05/01/1993 - "The results fail to support studies that report widespread benefit in aphthae of gluten withdrawal and suggest simply a marked placebo response in the condition." 05/01/1993 - "Fifty patients with a history of minor recurrent aphthous stomatitis were entered into a 6-month double-blind controlled trial of a gluten-free diet" 12/01/2007 - "Recurrent aphthous stomatitis disappeared in 89% of the patients after 1 year of gluten-free diet" Order ALL the reference details at left...
7.	Dentifrices (Dentifrice)IBA 12/01/1997 - "A statistically significant reduction in recurrent aphthous ulcers was observed during 2 months' use of SLS-free dentifrice compared to 2 months' use of the SLS-containing dentifrice" 01/01/2004 - "PURPOSE: A multicenter, double-blind, randomized, placebo-controlled clinical trial was conducted to determine the efficacy of an experimental dentifrice on the prevention of recurrent aphthous stomatitis (RAS)" 12/01/1997 - "These results support the results of an earlier independent study, and suggest that use of an SLS-free dentifrice should be considered for individuals suffering from recurrent aphthous ulcers." 01/01/2004 - "The effect of a dentifrice in the prevention of recurrent aphthous stomatitis." 10/01/1994 - "The results showed a statistically significant decrease in the number of aphthous ulcers from 14.3 after using the SLS-containing dentifrice to 5.1 ulcers after brushing with the SLS-free dentifrice (p < 0.05)" Order ALL the reference details at left...
8.	Immunoglobulin G (IgG)IBA 05/01/1996 - "In a preliminary study on anti-human cytomegalovirus (HCMV) antibody (Ab) by ELISA, the serum anti-HCMV/IgG Ab concentrations in 22 patients with recurrent aphthous ulcers (RAU) in the remission stage were found to be significantly higher than in 22 control subjects (121 +/- 42 vs 100 +/- 27, P < 0.05) and in 39 patients with RAU in the active stage (121 +/- 42 vs 88 +/- 45, P < 0.01)" 12/01/2005 - "Pylori antibody (IgG), and it is probable that these bacteria are not involved in recurrent oral aphthous ulcers." 11/01/1996 - "Immunoglobulin G subclass measurements in recurrent aphthous stomatitis." 01/01/1992 - "Serum levels of immunoglobulin G (IgG) subclasses were examined in 71 adult patients with minor recurrent aphthous stomatitis (MiRAS)" 01/01/1992 - "Immunoglobulin G subclasses in recurrent aphthous stomatitis." Order ALL the reference details at left...
9.	Tissue Adhesives (Tissue Adhesive)IBA 01/01/1970 - "Treatment of aphthae with tissue adhesives" 03/01/2001 - "CLINICAL IMPLICATIONS: Our clinical trials indicate that these novel tissue adhesives could be used as nonprescription, over-the-counter devices to provide significant pain relief for patients suffering from aphthous ulcers." 03/01/2001 - "In the first study, the investigators applied the tissue adhesive to the aphthous ulcers; in the second trial, the subjects themselves applied the tissue adhesive to their ulcers" 04/01/2000 - "OBJECTIVE: A device to standardize imaging was coupled with a digital intraoral camera to investigate the efficacy of 2-octyl cyanoacrylate (OC) tissue adhesives on the healing of minor aphthous ulcers" Order ALL the reference details at left...
10.	Folic Acid (Vitamin M)FDA LinkGeneric 11/01/1997 - "Folic acid may be beneficial in aphthous stomatitis." 07/08/1980 - "Folic acid and its effect on lymphocyte blastic transformation in patients with recurrent aphthous stomatitis (author's transl)]" 08/02/1975 - "Letter: Recurrent aphthae: treatment with vitamin B12, folic acid, and iron." 05/31/1975 - "Recurrent aphthae: treatment with vitamin B12, folic acid, and iron." 05/31/1975 - "A series of 130 consecutive outpatients with recurrent aphthous stomatitis were screened at the oral medicine department, Glasgow Dental Hospital, for deficienciesin vitamin b12, folic acid, and iron" Order ALL the reference details at left...

Therapies and Procedures

1.	Lasers (Laser) 06/01/1986 - "Clinical study of treatment of recurrent aphthae with the (He-Ne) laser]" 01/01/2000 - "Seventy-five patients with relapsing aphthous stomatitis (41 with the fibrinous form, 25 with glandular form, and 9 with necrotic form) were treated using He-Ne laser and a photosensitizer" 08/01/1996 - "Aphthous ulcers and lasers." 06/01/1991 - "Managing aphthous ulcers: laser treatment applied." 05/01/1992 - "Laser therapy and laser acupuncture of the biologically active sites were administered to 24 patients with chronic recurrent aphthous stomatitis" Order ALL the reference details at left...
2.	Tonsillectomy 05/01/2008 - "The role of tonsillectomy in management of periodic fever, aphthous stomatitis, pharyngitis, and adenopathy: Unanswered questions." 01/01/2008 - "OBJECTIVE: To examine the efficacy of tonsillectomy in ameliorating symptoms and preventing recurrence of episodes in children with PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis, and adenitis)" 05/01/2008 - "Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome is not always successful." 09/01/2007 - "OBJECTIVE: We carried out a prospective, randomized, controlled trial to clarify the effect of tonsillectomy on the clinical course of periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome" 09/01/2007 - "A randomized, controlled trial of tonsillectomy in periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome." Order ALL the reference details at left...
3.	Laser Therapy (Surgery, Laser) 11/01/1992 - "Recurrent aphthous ulcers: etiology and laser ablation." 01/01/1988 - "The use of low energy laser therapy to treat aphthous ulcers." 05/01/1992 - "Laser therapy and laser acupuncture of the biologically active sites were administered to 24 patients with chronic recurrent aphthous stomatitis" 05/01/1992 - "The laser therapy and laser acupunture of patients with chronic recurrent aphthous stomatitis]" 06/01/1991 - "Carbon dioxide laser therapy was used to treat a minor form of the ulcer (canker sore); the laser therapy reduced or eliminated the pain and inflammation with normal wound healing." Order ALL the reference details at left...
4.	Gas Lasers 06/01/1991 - "Carbon dioxide laser therapy was used to treat a minor form of the ulcer (canker sore); the laser therapy reduced or eliminated the pain and inflammation with normal wound healing." 01/01/2003 - "Clinical outcomes and complications for the use of the CO2 laser are presented for the following stomatological conditions: leukoplakia, lichen planus, benign soft-tissue and salivary gland tumors, reactive soft tissue changes (i.e., fibroepithelial polyps), recurrent aphthous stomatitis, drug-induced gingival hyperplasia, mucous extravasation and mucous retention cysts, herpes simplex virus-induced lesions, maxillary midline frenum, and ankyloglossia (tongue-tie)" Order ALL the reference details at left...
5.	Dentures 07/01/1990 - "The efficacy of a commercially available He-Ne-Laser in the treatment of alveolitis, solitary aphthae, ulcers caused by dentures, herpes simplex labialis, marginal periodontopathy and pericoronitis was investigated in 90 cases" Order ALL the reference details at left...

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