Stigmasterol

01/01/2022 - "The current study attempts to conduct a literature review on stigmasterol for its anti-tumor effect to provide reference for researchers and clinical workers."
01/01/2022 - "Multiple studies have revealed that stigmasterol holds promise as a potentially beneficial therapeutic agent for malignant tumors because of its significant anti-tumor bioactivity. "
01/01/2015 - "From the present study, it can be inferred that stigmasterol has chemopreventive activity in an experimental model of cancer. "
01/01/2022 - "Presently, stigmasterol has been poorly understood, and there is a paucity of systemic review on the mechanism underlying its anti-tumor effect. "
01/01/2022 - "There have been multiple mechanisms underlying the anti-tumor effect of stigmasterol, which make stigmasterol promising as a new anti-tumor agent and provide insights into research on its anti-tumor role. "

01/01/2021 - "Our study aimed to identify the effects of stigmasterol on experimental colitis and the related mechanisms. "
11/15/2017 - "These results suggest that dietary intake of stigmasterol and β-sitosterol ameliorates colitis. "
01/01/2021 - "Stigmasterol Restores the Balance of Treg/Th17 Cells by Activating the Butyrate-PPARγ Axis in Colitis."
11/15/2017 - "Both β-sitosterol and stigmasterol significantly inhibited colon shortening, lowered fecal hemoglobin content, and reduced the severity of colitis in the middle and distal colon (p < 0.05). "
11/15/2017 - "In this study, we investigated and compared the effects of stigmasterol and β-sitosterol (both with purities ≥95%) on dextran sulfate sodium (DSS)-induced colitis in C57BL/6J male mice fed a high fat Western-style diet. "

05/28/2020 - "Our findings suggest that stigmasterol can be used as a new treatment for ovarian cancer."
05/28/2020 - "We confirmed that stigmasterol suppressed cell migration and angiogenesis genes in human ovarian cancer cells. "
05/28/2020 - "Stigmasterol inhibited development of human ovarian cancer cells. "
05/28/2020 - "We also conducted migration assay to confirm whether that stigmasterol inhibits ovarian cancer cell migration. "
05/28/2020 - "However, there are no reports on stigmasterol's effects on ovarian cancer. "

09/01/2018 - "Coclusion: The results of this study indicate that stigmasterol could prove beneficial in the treatment of gastric cancer and therefore further in vivo studies are required to confirm its efficacy within biosystems."
01/01/2021 - "Stigmasterol Simultaneously Induces Apoptosis and Protective Autophagy by Inhibiting Akt/mTOR Pathway in Gastric Cancer Cells."
09/01/2018 - "The results showed that stigmasterol inhibited the growth of gastric cancer cells as observed by MTT and colony formation assay. "
09/01/2018 - "Stigmasterol exhibits potent antitumor effects in human gastric cancer cells mediated via inhibition of cell migration, cell cycle arrest, mitochondrial mediated apoptosis and inhibition of JAK/STAT signalling pathway."
09/01/2018 - "To investigate the anticancer effects of stigmasterol on the human gastric cancer cell line SNU-1, GES-1 normal cell line and to also investigate the effects on cancer cell migration, cell cycle phase distribution, apoptosis and JAK/STAT signalling pathway. "

05/01/2018 - "Several medicinal compounds including ascorbic acid, asiatic acid, oleanolic acid, stevioside, stigmasterol, and α-humulene were identified in the crude extract of CA. Findings from this study suggest CA may protect diabetic tissues from stress via antioxidant and anti-inflammatory mechanisms that can be useful in the management of diabetic complications."