HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)

A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.
Also Known As:
17 alpha Hydroxylase; CYP17; Hydroxyprogesterone Aldolase; Steroid 17 alpha-Monooxygenase; 17 alpha-Hydroxylase Cytochrome P-450; 17 alpha-Hydroxyprogesterone Aldolase; 17,20-Desmolase; Cytochrome P-450(17-alpha); Cytochrome P450(17 alpha); Steroid 17 alpha-Hydroxylase; Steroid-17-Hydroxylase; 17 alpha Hydroxylase Cytochrome P 450; 17 alpha Hydroxyprogesterone Aldolase; 17 alpha-Hydroxylase, Steroid; 17 alpha-Monooxygenase, Steroid; 17,20 Desmolase; 17,20 Lyase; 17-Hydroxylase, Steroid; 17-Monooxygenase, Steroid; 17-alpha-Hydroxylase, Steroid; Aldolase, 17 alpha-Hydroxyprogesterone; Aldolase, Hydroxyprogesterone; Steroid 17 Hydroxylase; Steroid 17 Monooxygenase; Steroid 17 alpha Hydroxylase; Steroid 17 alpha Monooxygenase; alpha-Hydroxylase, 17; alpha-Hydroxyprogesterone Aldolase, 17; alpha-Monooxygenase, Steroid 17; 17 alpha-Hydroxylase; 17,20-Lyase; Cytochrome P-450(17 alpha); P450(c17); Steroid 17-Hydroxylase; Steroid 17-Monooxygenase; Steroid, hydrogen-donor:oxygen oxidoreductase (17 alpha-hydroxylating)
Networked: 592 relevant articles (12 outcomes, 119 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Hartmann, Rolf W: 10 articles (08/2013 - 12/2004)
2. Njar, Vincent C O: 9 articles (05/2011 - 10/2004)
3. Auchus, Richard J: 8 articles (04/2015 - 12/2003)
4. Hu, Qingzhong: 8 articles (01/2014 - 08/2008)
5. Attard, Gerhardt: 8 articles (08/2011 - 08/2008)
6. de Bono, Johann S: 7 articles (04/2011 - 08/2008)
7. Miller, Walter L: 6 articles (06/2015 - 06/2004)
8. Qiao, Jie: 5 articles (02/2015 - 03/2010)
9. Flück, Christa E: 5 articles (05/2014 - 08/2006)
10. Tsai, Fuu-Jen: 5 articles (10/2005 - 07/2003)

Related Diseases

1. Prostatic Neoplasms (Prostate Cancer)
2. Neoplasms (Cancer)
3. Prostatic Diseases
4. Breast Neoplasms (Breast Cancer)
5. Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal)

Related Drugs and Biologics

1. Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)
2. abiraterone
3. Androgen Receptors (Androgen Receptor)
4. docetaxel (Taxotere)
5. Cytochrome P-450 CYP1A1 (CYP1A1)
6. Cytochromes
7. Cytochrome P-450 Enzyme System (Cytochrome P450)
8. Oxidoreductases
9. DNA (Deoxyribonucleic Acid)
10. Androgens

Related Therapies and Procedures

1. Castration
2. Drug Therapy (Chemotherapy)
3. Heterologous Transplantation (Xenotransplantation)
4. Immunotherapy
5. Chemoprevention