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Steroid 12-alpha-Hydroxylase (CYP8B1)

A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol.
Also Known As:
CYP8B1; 12alpha-Hydroxylase; Cytochrome P450 8B1; Cytochrome P450 CYP8B1; Steroid 12-Hydroxylase; Steroid-12-Hydroxylase; Steroid-12-Monooxygenase; Sterol 12 alpha-Hydroxylase; 12 alpha Hydroxylase; 12 alpha-Hydroxylase, Sterol; 12alpha Hydroxylase; Steroid 12 Hydroxylase; Steroid 12 Monooxygenase; Steroid 12 alpha Hydroxylase; Sterol 12 alpha Hydroxylase; alpha-Hydroxylase, Sterol 12; 12-alpha-Hydroxylase; Steroid 12-Monooxygenase; Sterol 12-alpha-Hydroxylase; Steroid, hydrogen-donor:oxygen oxidoreductase (12-alpha-hydroxylating)
Networked: 16 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Huang, Wei: 2 articles (04/2013 - 08/2011)
2. Hua, Qi: 2 articles (04/2013 - 08/2011)
3. Qin, Jian: 2 articles (04/2013 - 08/2011)
4. Wang, Xiang-Dong: 1 article (01/2015)
5. Hu, Kang-Quan: 1 article (01/2015)
6. Liu, Chun: 1 article (01/2015)
7. Lian, Fuzhi: 1 article (01/2015)
8. Li, Xinli: 1 article (01/2015)
9. Rahnenführer, Jörg: 1 article (12/2014)
10. Widera, Agata: 1 article (12/2014)

Related Diseases

1. Gallstones (Gallstone)
2. Starvation
3. Fibrosis (Cirrhosis)
4. Dyslipidemias (Dyslipidemia)
5. Liver Failure

Related Drugs and Biologics

1. Messenger RNA (mRNA)
2. Cholesterol
3. Cholic Acid
4. Steroid 12-alpha-Hydroxylase (CYP8B1)
5. Nicotinamide Phosphoribosyltransferase
6. Cytochrome P-450 CYP2E1 (CYP2E1)
7. Thyroxine (Levothyroxine)
8. Streptozocin (Streptozotocin)
9. RNA (Ribonucleic Acid)
10. Proteins (Proteins, Gene)

Related Therapies and Procedures

1. Hypophysectomy