|1.||Hartmann, Rolf W: 8 articles (01/2015 - 08/2010)|
|2.||Krone, Nils: 5 articles (10/2013 - 06/2005)|
|3.||Fraser, Robert: 5 articles (09/2013 - 02/2005)|
|4.||Davies, Eleanor: 5 articles (09/2013 - 02/2005)|
|5.||Morel, Y: 5 articles (01/2010 - 11/2000)|
|6.||Mulatero, Paolo: 4 articles (08/2015 - 07/2002)|
|7.||Veglio, Franco: 4 articles (08/2015 - 07/2002)|
|8.||Hu, Qingzhong: 4 articles (09/2014 - 08/2010)|
|9.||Riepe, Felix G: 4 articles (02/2012 - 06/2005)|
|10.||Gordon, R D: 4 articles (04/2008 - 11/2000)|
|1.||Hypertension (High Blood Pressure)
10/01/2010 - "The associations between CYPB11B2/CYP11B1 polymorphisms and persistent postoperative hypertension were assessed by multivariate analysis. "
12/01/2006 - "No variants were identified in the coding region of CYP11B1 that could account for hypertension and/or a raised ARR. "
12/01/2006 - "We therefore aimed to determine whether there is an association between CYP11B1 variants and hypertension and/or an altered ARR. "
10/01/2003 - "Anaesthesia for a girl with severe hypertension due to 11 beta-hydroxylase deficiency."
11/01/2000 - "Genetic analysis showed two new base substitutions of CYP11B1, a conservative transition at the last base of exon 5, and a IVS8+4A-->G transition in intron 8. Difficulties with suppressive therapy resulted in severe hypertension. "
12/12/2013 - "Inhibition of CYP11B1 is being evaluated in the clinic for potential treatment of hypercortisol diseases such as Cushing's syndrome. "
07/26/2012 - "CYP11B1 inhibition is a promising therapy for Cushing's syndrome. "
07/26/2012 - "Novel imidazol-1-ylmethyl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-ones as potent and selective CYP11B1 inhibitors for the treatment of Cushing's syndrome."
08/08/2013 - "Potent and selective CYP11B1 inhibitors could be promising therapeutics for the treatment of Cushing's syndrome. "
01/01/1990 - "2) Adrenal adenoma formation in patients with Cushing's syndrome is accompanied by a relative blockade of 11 beta-hydroxylase activity. "
|3.||Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal)
08/01/1996 - "This case illustrates difficulties in correct diagnosis, choice of appropriate steroid regimen and monitoring efficacy of treatment in congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency. "
11/10/2012 - "The objective of this study was to screen the CYP11B1 gene for mutations in one Vietnamese male suffering from congenital adrenal hyperplasia. "
04/01/1985 - "Studies in three families (A, B, and C) revealed five patients with congenital adrenal hyperplasia (CAH) due to partial and combined 21- and 11 beta-hydroxylase deficiency. "
01/01/1982 - "Studies in 18 Jewish families from Morocco, Tunis, Turkey and Iran revealed 26 patients with congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency. "
09/01/1980 - "These findings are consistent with previous in vitro studies and studies in patients with congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency, suggesting that a single enzyme system is responsible for both 11 beta- and 18-hydroxylation of DOC in the adrenal zona fasciculata. "
01/01/1989 - "Nevertheless the neonate also has severe virilization of the external genitalia and postnatal hormonal studies confirmed the diagnosis of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency. "
03/01/2001 - "Based on the author's experience, prenatal diagnosis and treatment of 21-hydroxylase deficiency is safe and effective in significantly reducing or eliminating virilization in the affected female, and the same outcome seems to be true in the treatment of 11 beta-hydroxylase deficiency. "
01/01/2008 - "A homozygous L299P mutation in the CYP11B1 gene leads to complete virilization in 46,XX individuals with 11-beta-hydroxylase deficiency."
01/01/2007 - "11 beta-Hydroxylase deficiency is a rare form of congenital adrenal hyperplasia, resulting in virilization, glucocorticoid deficiency and hypertension. "
01/01/2001 - "Molecular defects of the CYP11B1 gene lead to 11-hydroxylase deficiency, which is clinically expressed with virilization of the external genitalia of the female and precocious puberty in the male, as well as hypertension in both sexes. "
|2.||Aldosterone Synthase (CYP11B2)
|3.||Steroid 21-Hydroxylase (21 Hydroxylase)
|6.||Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)
|9.||Steroid 11-beta-Hydroxylase (11 beta-Hydroxylase)
|2.||Cardiopulmonary Resuscitation (CPR)