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Steroid 11-beta-Hydroxylase (11 beta-Hydroxylase)

A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11B1 gene, is important in the synthesis of CORTICOSTERONE and HYDROCORTISONE. Defects in CYP11B1 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
Also Known As:
11 beta-Hydroxylase; Steroid 11 beta Hydroxylase; CYP11B1; CYP 11B1; Cytochrome P450 11B1; Steroid 11 Hydroxylase; Steroid 11-Hydroxylase; Steroid-11-Hydroxylase; 11 beta Hydroxylase; Cytochrome P 450 CYP11B1; Steroid 11 beta Monooxygenase; Cytochrome P-450 CYP11B1; Cytochrome P-450(11 beta); Steroid 11-beta-Monooxygenase; Steroid, reduced-adrenal-ferredoxin:oxygen oxidoreductase (11 beta-hydroxylating)
Networked: 323 relevant articles (8 outcomes, 30 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Gomez-Sanchez, Celso E: 11 articles (07/2020 - 07/2002)
2. Hartmann, Rolf W: 11 articles (01/2019 - 08/2010)
3. Sasano, Hironobu: 7 articles (01/2022 - 07/2014)
4. Hu, Qingzhong: 7 articles (01/2019 - 08/2010)
5. Davies, Eleanor: 7 articles (03/2017 - 02/2005)
6. Nakamura, Yasuhiro: 6 articles (01/2022 - 07/2014)
7. Holterhus, Paul-Martin: 6 articles (05/2020 - 07/2006)
8. Riepe, Felix G: 6 articles (05/2020 - 06/2005)
9. Nishimoto, Koshiro: 6 articles (11/2019 - 05/2010)
10. Mukai, Kuniaki: 6 articles (11/2017 - 05/2010)

Related Diseases

1. Hypertension (High Blood Pressure)
2. Cushing Syndrome
3. Adenoma (Adenomas)
4. Pituitary ACTH Hypersecretion
5. Necrosis

Related Drugs and Biologics

1. Metyrapone
2. Cytochrome P-450 CYP11B2 (CYP11B2)
3. Cytochrome P450 Family 11
4. Aromatase Inhibitors
5. Corticosterone
6. LH Receptors (LH Receptor)
7. Luteinizing Hormone (Lutropin)
8. Isoxazoles
9. Chorionic Gonadotropin (Human Chorionic Gonadotropin)
10. Hydrocortisone (Cortisol)

Related Therapies and Procedures

1. Adrenalectomy
2. Therapeutics