Steroid 11-beta-Hydroxylase (11 beta-Hydroxylase)

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217 relevant articles (6 outcomes, 19 trials/studies) found for this Bio-Agent

Description: A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11B1 gene, is important in the synthesis of CORTICOSTERONE and HYDROCORTISONE. Defects in CYP11B1 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).

Also Known As:

11 beta-Hydroxylase; Steroid 11 beta Hydroxylase; CYP11B1; CYP 11B1; Cytochrome P450 11B1; Steroid 11 Hydroxylase; Steroid 11-Hydroxylase; Steroid-11-Hydroxylase; 11 beta Hydroxylase; Cytochrome P 450 CYP11B1; Steroid 11 beta Monooxygenase; Cytochrome P-450 CYP11B1; Cytochrome P-450(11 beta); Steroid 11-beta-Monooxygenase; Steroid, reduced-adrenal-ferredoxin:oxygen oxidoreductase (11 beta-hydroxylating)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Morel, Y: 4 articles (01/2007 - 11/2000)
2.	Mulatero, P: 2 articles (12/2002 - 07/2001)
3.	Chabre, O: 2 articles (11/2000 - 11/2000)
4.	Defaye, G: 2 articles (11/2000 - 11/2000)
5.	Portrat-Doyen, S: 2 articles (11/2000 - 11/2000)
6.	Vivier, J: 2 articles (11/2000 - 11/2000)
7.	Bernhardt, Rita: 1 article (01/2008)
8.	Riedl, Stefan: 1 article (01/2008)
9.	Waldhauser, Franz: 1 article (01/2008)
10.	Schulze, Egbert: 1 article (01/2008)

Related Diseases

1.	Hypertension (High Blood Pressure) 12/01/2006 - "CONCLUSION: No variants were identified in the coding region of CYP11B1 that could account for hypertension and/or a raised ARR" 12/01/2006 - "We therefore aimed to determine whether there is an association between CYP11B1 variants and hypertension and/or an altered ARR" 10/01/2003 - "Anaesthesia for a girl with severe hypertension due to 11 beta-hydroxylase deficiency." 11/01/2000 - "Genetic analysis showed two new base substitutions of CYP11B1, a conservative transition at the last base of exon 5, and a IVS8+4A-->G transition in intron 8. Difficulties with suppressive therapy resulted in severe hypertension" 08/01/1998 - "Statistical analyses did not show significant linkage of the CYP11B1 microsatellite marker to hypertension" Order ALL the reference details at left...
2.	Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal) 08/01/1996 - "This case illustrates difficulties in correct diagnosis, choice of appropriate steroid regimen and monitoring efficacy of treatment in congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency" 04/01/1985 - "Studies in three families (A, B, and C) revealed five patients with congenital adrenal hyperplasia (CAH) due to partial and combined 21- and 11 beta-hydroxylase deficiency" 01/01/1982 - "Studies in 18 Jewish families from Morocco, Tunis, Turkey and Iran revealed 26 patients with congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency" 09/01/1980 - "These findings are consistent with previous in vitro studies and studies in patients with congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency, suggesting that a single enzyme system is responsible for both 11 beta- and 18-hydroxylation of DOC in the adrenal zona fasciculata" 03/01/1980 - "Hormonal studies in obligate heterozygotes and siblings of patients with 11 beta-hydroxylase deficiency congenital adrenal hyperplasia." Order ALL the reference details at left...
3.	Cushing Syndrome 01/01/1990 - "2) Adrenal adenoma formation in patients with Cushing's syndrome is accompanied by a relative blockade of 11 beta-hydroxylase activity" 06/01/1994 - "For metyrapone, an inhibitor of adrenal 11 beta-hydroxylase, promising results were reported for the treatment of Cushing's syndrome" 01/01/2002 - "Coexistence of 21-hydroxylase and 11 beta-hydroxylase deficiency in adrenal incidentalomas and in subclinical Cushing's syndrome." 02/01/2003 - "Adenomas from patients with Cushing's syndrome have a strong expression of CYP11B1 and CYP17" 05/01/1988 - "The activity of 11 beta-hydroxylase was investigated in the mitochondrial fractions of 19 surgically resected adrenocortical tumors associated with Cushing's syndrome (4 adenomas and 2 carcinomas), primary aldosteronism (8 adenomas), adrenogenital syndrome (AGS) (2 carcinomas) and no hormonal symptoms (3 adenomas)" Order ALL the reference details at left...
4.	Virilism (Virilization) 01/01/2008 - "A homozygous L299P mutation in the CYP11B1 gene leads to complete virilization in 46,XX individuals with 11-beta-hydroxylase deficiency." 01/01/1989 - "Nevertheless the neonate also has severe virilization of the external genitalia and postnatal hormonal studies confirmed the diagnosis of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency" 03/01/2001 - "Based on the author's experience, prenatal diagnosis and treatment of 21-hydroxylase deficiency is safe and effective in significantly reducing or eliminating virilization in the affected female, and the same outcome seems to be true in the treatment of 11 beta-hydroxylase deficiency" 01/01/2007 - "11 beta-Hydroxylase deficiency is a rare form of congenital adrenal hyperplasia, resulting in virilization, glucocorticoid deficiency and hypertension" 01/01/2001 - "Molecular defects of the CYP11B1 gene lead to 11-hydroxylase deficiency, which is clinically expressed with virilization of the external genitalia of the female and precocious puberty in the male, as well as hypertension in both sexes" Order ALL the reference details at left...
5.	Necrosis 12/14/1987 - "In addition, metyrapone, an efficient and specific inhibitor of the mitochondrial 11 beta-hydroxylase, provided protection against DMBA-induced toxicity, which is in agreement with previous observations that adrenal necrosis caused by DMBA apparently originates in mitochondria" Order ALL the reference details at left...

Related Drugs and Biologics

1.	Metyrapone
2.	Steroid 21-Hydroxylase (21 Hydroxylase)
3.	9,10-Dimethyl-1,2-benzanthracene (DMBA)
4.	Aldosterone Synthase (CYP11B2)
5.	Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)
6.