Steatitis

A disease of cats and mink characterized by a marked inflammation of adipose tissue and the deposition of "ceroid" pigment in the interstices of the adipose cells. It is believed to be caused by feeding diets containing too much unsaturated fatty acid and too little vitamin E. (Merck Veterinary Manual, 5th ed; Stedman, 25th ed)

Also Known As:

Networked: 23 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Vitamin E Deficiency
2.	Muscular Diseases (Myopathy)
3.	Abdominal Pain (Pain, Abdominal)
4.	Ectopic Pregnancy
5.	Neoplasms (Cancer)

Experts

1.	Murata, Koichi: 2 articles (01/2015 - 01/2011)
2.	Neagari, Yasuko: 2 articles (01/2015 - 01/2011)
3.	Chantrey, Julian: 1 article (09/2021)
4.	García, Gerardo: 1 article (09/2021)
5.	Lopez, Javier: 1 article (09/2021)
6.	Payne, Imogen L: 1 article (09/2021)
7.	Rich, Andrew F: 1 article (09/2021)
8.	Alexander, Amy B: 1 article (01/2021)
9.	Arendt, Michael D: 1 article (01/2021)
10.	Brisson, Jennifer: 1 article (01/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Steatitis:

1.	Vitamin EFDA LinkGeneric 01/01/2021 - "By highlighting the need to provide more effective vitamin E supplementation, and the need to re-assess specific components of the diet, this study may lead to reduced incidence and improved medical management of steatitis in cold-stunned sea turtles." 01/01/2011 - "Egrets with steatitis had low blood levels of vitamin E. " 07/01/1954 - "Experimental production of steatitis yellow fat disease) in kittens fed a commercial canned cat food and prevention of the condition by vitamin E." 09/01/2003 - "These findings suggest that vitamin E deficiency may be involved in the development of anemia, myopathy, and steatitis in callitrichids; however, in some marmosets, underlying diseases such as chronic colitis may have influenced the development of anemia and impaired vitamin E status." 04/01/1992 - "Some syndromes, such as steatitis in cats, result from an increased requirement of vitamin E in diets that contain large amounts of polyunsaturated fatty acids, and these diseases will only respond to vitamin E administration. "
2.	Tocopherols (Tocopherol)IBA 01/01/2021 - "The objectives of this study were to investigate the clinical (n = 23) and histologic findings (n = 11) in cold-stunned KRT, and to compare plasma concentrations of α-tocopherol (vitamin E), thiobarbituric acid reactive substances (TBARS), and the TBARS to vitamin E (T/E) ratio (an assessment of oxidative stress) between cold-stunned KRT with clinically and/or histologically confirmed steatitis (n = 10) and free-ranging KRT (n = 9). "
3.	Thiobarbituric Acid Reactive SubstancesIBA 01/01/2021 - "The objectives of this study were to investigate the clinical (n = 23) and histologic findings (n = 11) in cold-stunned KRT, and to compare plasma concentrations of α-tocopherol (vitamin E), thiobarbituric acid reactive substances (TBARS), and the TBARS to vitamin E (T/E) ratio (an assessment of oxidative stress) between cold-stunned KRT with clinically and/or histologically confirmed steatitis (n = 10) and free-ranging KRT (n = 9). "
4.	AntioxidantsIBA 08/01/2006 - "In conclusion, the results of this study have shown that although the morbidity rate is not different between the two breeds, the delay of Siamese cats to develop symptomatic steatitis is presumably attributed to an inherent resistance as a result of the long-standing evolution of more efficient antioxidant mechanisms. "
5.	microcystinIBA 01/01/2015 - "This study aimed to verify a hypothesis that the egrets and herons which died in the reservoir drink microcystin-producing cyanobacteria and microcystin involves in the cause of death as well as the symptoms of steatitis. "
6.	CeroidIBA 12/01/1999 - "Necropsy revealed a generalized steatitis, and histology showed a necrotizing and granulomatous pansteatitis with intralesional pigment compatible with ceroid. " 12/01/1983 - "The histopathologic diagnosis was granulomatous steatitis, with fat necrosis, based on the finding of multinucleated giant cells, ceroid, and multiple foci of inflammatory cells." 07/01/1979 - "Microscopically, myopathy and steatitis were observed, together with an extensive ceroid storage. " 07/01/2011 - "Necrosis and inflammation of the adipose tissues, with characteristic ceroid accumulation within the resultant granulomata and the associated aggregation of ceroid-containing macrophages, were demonstrated histologically and were typical of steatitis. "
7.	Fatty Acids (Saturated Fatty Acids)IBA 10/01/2019 - "We explored differences between the adipose tissue fatty acid profiles of Great Blue Herons (Ardea herodias) with and without steatitis. " 07/01/1994 - "Steatitis, a sensitive histopathological indicator of vitamin E deficiency in animals fed on diets rich in fatty acids with three or more double bonds, was observed only in the adipose tissue of the FO groups, even in the group with the highest DL-alpha-tocopheryl acetate supplementation. " 08/01/2006 - "Blood alpha-Tocopherol, selenium, and glutathione peroxidase changes and adipose tissue fatty acid changes in kittens with experimental steatitis (yellow fat disease): a comparative study between the domestic shorthaired and Siamese breed."
8.	alpha-TocopherolFDA Link 07/01/1994 - "Steatitis, a sensitive histopathological indicator of vitamin E deficiency in animals fed on diets rich in fatty acids with three or more double bonds, was observed only in the adipose tissue of the FO groups, even in the group with the highest DL-alpha-tocopheryl acetate supplementation. " 08/01/2006 - "Blood alpha-Tocopherol, selenium, and glutathione peroxidase changes and adipose tissue fatty acid changes in kittens with experimental steatitis (yellow fat disease): a comparative study between the domestic shorthaired and Siamese breed."
9.	SeleniumIBA 07/01/1986 - "Generalized steatitis associated with selenium deficiency and normal vitamin E status in a foal." 08/01/2006 - "Blood alpha-Tocopherol, selenium, and glutathione peroxidase changes and adipose tissue fatty acid changes in kittens with experimental steatitis (yellow fat disease): a comparative study between the domestic shorthaired and Siamese breed."
10.	LipidsIBA 01/01/2017 - "There was no direct evidence of thyroid disruption, but this cannot be ruled out until further research determines the factors that underlie the homeostatic shift leading to elevated plasma and liver lipids and T3 levels in steatitis-affected tilapia." 01/01/2017 - "There were distinct sex and seasonal differences, with the highest plasma lipids and T3 levels observed in steatitis-affected females during spring and summer. " 01/15/1974 - "Non-extractable lipids in the adipose tissues of horses and ponies affected with generalized steatitis." 01/15/1974 - "When adipose tissues of horses and ponies affected with generalized steatitis were extracted by acetone, methanol and chloroform, non-extractable lipids were found to be present, which had become insoluble as a result of peroxidation and polymerization and had acquired autofluorescent characteristics. "

Therapies and Procedures

1.	Catheters 01/01/2023 - "Complications encountered include mild abdominal effusion, unsuccessful placement resulting in hemorrhagic abdominal effusion, steatitis, abdominal pain, and kinking of the catheter. "
2.	Surgical Portasystemic Shunt (Portosystemic Shunt) 10/15/1994 - "In 2 cats, chylous ascites was associated with nonneoplastic diseases: 1 cat had severe biliary cirrhosis and an extrahepatic portosystemic shunt; the other had steatitis caused by vitamin E deficiency. "
3.	Laparotomy 04/01/1994 - "In an eight-year old Galloway cow, an ectopic pregnancy with mummification of the fetus which had been assumed because of history and clinical examination of the animal was diagnosed as a "tumor of the adipose tissue" (steatitis) following exploratory laparotomy. "