|1.||Ntambi, James M: 19 articles (12/2011 - 06/2002)|
|2.||Dobrzyn, Agnieszka: 8 articles (10/2014 - 02/2004)|
|3.||Miyazaki, Makoto: 8 articles (08/2010 - 11/2002)|
|4.||Dobrzyn, Pawel: 6 articles (10/2014 - 09/2004)|
|5.||Flowers, Matthew T: 6 articles (08/2012 - 01/2007)|
|6.||Igal, R Ariel: 5 articles (09/2012 - 02/2005)|
|7.||Huang, Zheng: 5 articles (01/2012 - 03/2010)|
|8.||Zhang, Lei: 5 articles (01/2012 - 03/2010)|
|9.||Ramtohul, Yeeman K: 4 articles (01/2012 - 03/2010)|
|10.||Li, Chun Sing: 4 articles (01/2012 - 03/2010)|
01/01/2012 - "Up-regulation of stearoyl-CoA desaturase (SCD) is closely related to improved insulin resistance. "
10/21/2011 - "The lipogenic enzyme stearoyl-CoA desaturase 1 is highly induced in SIRT3KO mice, and its deletion rescues both WT and SIRT3KO mice from HFD-induced hepatic steatosis and insulin resistance. "
06/01/2010 - "Increasing evidence suggests that stearoyl-CoA desaturase (SCD), the rate-limiting enzyme of monounsaturated fatty acid biosynthesis, is an important factor in the pathogenesis of lipid-induced insulin resistance. "
10/01/2006 - "Regression analysis of the total population showed that an increase in the C20:4 n-6/C20:3 n-6 ratio (estimated Delta5-desaturase activity) and reductions in the C18:3 n-6/C18:2 n-6 ratio (estimated Delta6-desaturase activity) and the C16:1 n-7/C16:0 ratio (estimated Delta9-desaturase activity or stearoyl-CoA desaturase-1) were significantly associated with a decrease in homeostasis model assessment for insulin resistance. "
12/01/2005 - "Gene expression profiling in skeletal muscle of Zucker diabetic fatty rats: implications for a role of stearoyl-CoA desaturase 1 in insulin resistance."
07/01/2014 - "Variations in stearoyl CoA desaturase (SCD) activity (a key enzyme in the fatty acid metabolism) may be involved in various processes that can lead to diseases such as obesity. "
05/02/2014 - "In addition, hepatic stearoyl-CoA desaturase 1 (SCD1) expression was decreased in Cyp1b1-null mice, and the attenuated diet-induced obesity and lower serum LPC 18:0 in the Cyp1b1-null mice is elevated after SCD1 overexpression, suggesting that SCD1 is correlated with CYP1B1-induced obesity. "
05/01/2014 - "Enhanced fatty-acid desaturation by stearoyl-CoA desaturase enzyme-1 (SCD1) is associated with obesity. "
12/01/2013 - "Polymorphisms in the SCD1 gene are associated with indices of stearoyl CoA desaturase activity and obesity: a prospective study."
09/01/2013 - "Stearoyl-CoA desaturase (SCD)-1 deficient mice are resistant to obesity and plasma SCD indices are related to obesity in humans. "
11/01/2011 - "In the studies reported here, we aimed to understand whether tumor cells require the activity of either human isoform of stearoyl-CoA-desaturase (SCD1 or SCD5) for survival. "
01/01/2013 - "Complete inhibition of stearoyl-CoA desaturase activity may be required to efficiently suppress liver tumor development."
05/01/2012 - "Using BCR-ABL-induced CML mouse model, here we show that expression of the stearoyl-CoA desaturase 1 (Scd1) gene is downregulated in LSCs and that Scd1 plays a tumor-suppressive role in LSCs with no effect on the function of normal hematopoietic stem cells. "
02/01/2011 - "The suppression of stearoyl-CoA desaturase expression reduces cancer cell proliferation and in-vitro invasiveness, and dramatically impairs tumor formation and growth. "
09/01/2010 - "Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer."
10/01/2014 - "The results show that stearoyl-CoA desaturase 1 regulates the level of DNA methylation in adipocytes and suggest that the mechanism by which stearoyl-CoA desaturase 1 affects adipocyte inflammation may involve changes in the methylation of inflammatory genes. "
10/01/2014 - "Stearoyl-CoA desaturase, a key adipogenic enzyme in rodents and humans, plays significant role in the regulation of adipocyte inflammation via a mechanism that involves the regulation of inflammatory gene expression. "
01/01/2011 - "Stearoyl CoA desaturase 1: role in cellular inflammation and stress."
01/01/2010 - "Stearoyl-CoA desaturase 1 (SCD1) is a critical regulator of energy metabolism and inflammation. "
10/01/2009 - "Therefore, stearoyl-CoA desaturase 1 may play an unexpected role in suppressing inflammation by preventing excessive accumulation of endogenous SFA-derived TLR4 agonists. "
|5.||Hepatocellular Carcinoma (Hepatoma)
01/01/2014 - "Stearoyl-CoA desaturase plays an important role in proliferation and chemoresistance in human hepatocellular carcinoma."
10/01/1974 - "Altered stearoyl-CoA desaturase activities in Morris hepatomas 5123C and 7800."
03/28/2015 - "Stearoyl-CoA desaturase 1 (SCD1) is a key regulator in the mechanisms of cell proliferation, survival and transformation to cancer, and autophagy also plays a critical role in hepatocellular carcinoma (HCC). "
07/01/1984 - "Analysis of the stearoyl-CoA desaturase system in cultured hepatoma cells suggests that these cells are similar to the host-grown tumor in this respect and may be used as a model in further examinations of the stearoyl-CoA desaturase system."
04/27/2013 - "To investigate the effect of MEK/ERK1/2 pathway on peroxisome proliferator-activated receptors (PPARγ) agonist-induced alterations in Δ6-desaturase (Δ6D) and stearoyl-CoA desaturase 1 (SCD1) in hepatocellular carcinoma cell line HepG2. "
|2.||Fatty Acid Synthetase Complex (Fatty Acid Synthase)
|4.||Fatty Acids (Saturated Fatty Acids)
|5.||Transcription Factors (Transcription Factor)
|6.||Carnitine O-Palmitoyltransferase (Carnitine Palmitoyltransferase II)
|8.||Biological Markers (Surrogate Marker)
|1.||Fat-Restricted Diet (Diet, Fat Restricted)
|2.||Homologous Transplantation (Allograft)