|2.||Status Epilepticus (Complex Partial Status Epilepticus)
|4.||Encephalitis (Encephalitis, Rasmussen)
|1.||Löscher, Wolfgang: 31 articles (12/2015 - 01/2002)|
|2.||Gorter, Jan A: 27 articles (03/2014 - 01/2002)|
|3.||Nehlig, Astrid: 25 articles (07/2015 - 02/2002)|
|4.||Kim, Ji-Eun: 23 articles (10/2015 - 03/2007)|
|5.||Henshall, David C: 23 articles (10/2015 - 02/2008)|
|6.||Kang, Tae-Cheon: 21 articles (09/2015 - 03/2007)|
|7.||DeLorenzo, Robert J: 21 articles (09/2014 - 10/2003)|
|8.||Aronica, Eleonora: 21 articles (02/2014 - 01/2002)|
|9.||Potschka, Heidrun: 20 articles (09/2015 - 04/2002)|
|10.||Rossetti, Andrea O: 20 articles (08/2015 - 07/2004)|
|1.||Midazolam (Versed)FDA LinkGeneric
12/01/2006 - "To assess the efficacy of high-dose midazolam in the treatment of refractory status epilepticus in children. "
01/09/2013 - "In 2012, intramuscular midazolam appears as effective as intravenous lorezepam for the first line treatment of convulsive status epilepticus. "
03/01/2003 - "[Proposal to obtain a licensed application for midazolam (Dormicam) as a drug effective for status epilepticus]."
09/01/1999 - "Midazolam infusion, as per our described algorithm, is effective in terminating refractory status epilepticus. "
07/01/1998 - "In conclusion, midazolam infusion is an effective and safe therapeutic approach for the management of childhood status epilepticus."
|2.||Diazepam (Valium)FDA LinkGeneric
03/01/2014 - "We sought to retrospectively evaluate the long-term efficacy of high-dose oral diazepam in reducing electrographic and clinical evidence of electrical status epilepticus during slow wave sleep in children. "
12/01/1984 - "Intravenous diazepam, used as the only therapy for status epilepticus, was effective in 58 of 78 episodes. "
04/01/1995 - "Diazepam is administered to children in status epilepticus by paramedics in many Emergency Medical Services systems throughout the United States despite the lack of clear evidence that this therapy is safe and effective when employed in the prehospital environment. "
01/01/1998 - "To determine efficacy of continuous diazepam infusion in the treatment of refractory status epilepticus in a retrospective study, we analyzed data of 62 children admitted consecutively to our Pediatric Intensive Care Unit with a diagnosis of refractory status epilepticus. "
02/01/2015 - "The aim of this study was to examine whether intranasal diazepam is an effective alternative to intravenous diazepam when treating status epilepticus. "
|3.||Valproic Acid (Valproate, Semisodium)FDA LinkGeneric
08/09/2005 - "Efficacy of rapid IV administration of valproic acid for status epilepticus."
01/25/2005 - "Efficacy of rapid IV administration of valproic acid for status epilepticus."
08/01/2015 - "Starting with the established antiepileptic drug, valproic acid, we have taken a novel approach to develop new antiseizure drugs that may be effective in status epilepticus. "
06/01/2010 - "Valproate sodium, a commonly used antiepileptic drug (AED), is effective for the treatment of status epilepticus and is often used as a second-line agent when other AEDs are contraindicated. "
01/01/2006 - "Intravenous valproate may be effective for the treatment of convulsive and non-convulsive status epilepticus that is refractory to conventional drugs. "
|4.||Pilocarpine (Ocusert)FDA LinkGeneric
05/01/2012 - "Its monoterpene, at 25, 50 and 75 mg/kg, was also capable to increase the latency for installation of status epilepticus induced by pilocarpine, and presented a significant protection against lipid peroxidation and nitrite formation in mice hippocampus (P < 0.05). "
02/01/2007 - "at 2 months after pilocarpine-induced status epilepticus, significant reduction of CCR7-10 expression in CB-, CR- and PV-immunpositive interneurons may suggest the phenotype change of surviving interneurons. "
10/29/2015 - "In the present study, we investigated whether endoplasmic reticulum (ER) stress is associated with neuronal- and astroglial-death in the hippocampus using LiCl-pilocarpine-induced status epilepticus (SE) rat model. "
12/01/2014 - "In this study, we used male rats, which were injected with saline or pilocarpine to induce status epilepticus (SE) and killed 24h, 3 and 7 days after pilocarpine administration. "
08/22/2014 - "The purpose of our study was to investigate whether a physical exercise program applied during brain development could influence the hippocampal plasticity of rats submitted to status epilepticus (SE) induced by pilocarpine model at two different ages of the postnatal period. "
|5.||etiracetam (levetiracetam)FDA LinkGeneric
08/01/2014 - "Intravenous levetiracetam (LEV) has been shown to be effective and safe in treating adults with refractory status epilepticus (SE). "
03/01/2014 - "Levetiracetam is effective in individuals with electrical status epilepticus during sleep with tolerable side effects."
01/01/2013 - "The relatively recent development of levetiracetam shows promise for effective control of acute status epilepticus in adults, but current objective data of its use as a first-line agent for control of status is quite limited. "
09/01/2009 - "IV levetiracetam was effective in stopping status epilepticus in both infants. "
01/15/2015 - "To investigate the antiepileptic and protective effects of intravenous levetiracetam (iv LEV) in the rhesus monkey model of acute status epilepticus (SE). "
|6.||Phenytoin (Dilantin)FDA LinkGeneric
08/01/1983 - "The efficacy of intravenous phenytoin for the treatment of status epilepticus is related to the rapid entry of phenytoin into brain parenchyma. "
11/01/2012 - "Phenytoin is rarely effective in controlling febrile status epilepticus. "
11/01/2012 - "Lack of efficacy of phenytoin in children presenting with febrile status epilepticus."
11/01/2012 - "Lack of efficacy of phenytoin in children presenting with febrile status epilepticus."
01/01/1983 - "Efficacy of phenytoin in treatment of status epilepticus."
|7.||Anticonvulsants (Antiepileptic Drugs)IBA
06/01/2011 - "We describe a 7-year-old pediatric case in which ECT was used successfully to treat medically refractory nonconvulsive status epilepticus (NCSE) without complete withdrawal of antiepileptic drugs (AED)."
02/01/2001 - "In status epilepticus, the optimal efficacy of the antiepileptic drugs depends notably on effective, quickly reached and sufficiently lasting cerebral concentrations and the optimal tolerability notably on the lack of excessive storage in the brain and other tissues. "
01/01/2005 - "In the present case, an add-on high-dose intravenous corticosteroid seems to be effective in the treatment of patients with electrical status epilepticus during slow-wave sleep syndrome, especially when antiepileptic drugs fail."
05/01/2006 - "The use of new antiepileptic drugs for treatment of status epilepticus (SE) has not been studied systematically, particularly with respect to response predictors, the possibility of a dose-response relationship, and the efficacy of administration through a nasogastric tube. "
12/14/1998 - "SSSE induced by PPS is an advantageous animal model of refractory status epilepticus, which may be used in preclinical studies of novel antiepileptic drugs."
08/30/2001 - "Benzodiazepines are safe and effective when administered by paramedics for out-of-hospital status epilepticus in adults. "
08/30/2001 - "It is uncertain whether the administration of benzodiazepines by paramedics is an effective and safe treatment for out-of-hospital status epilepticus. "
12/01/2012 - "Benzodiazepines have been used for decades as first-line treatment for status epilepticus (SE). "
03/01/2015 - "The objectives were to describe the frequency of repeat enrollment within a specific exception from informed consent trial testing benzodiazepine treatment of prehospital status epilepticus and to estimate the effect of repeat enrollments on the analysis of the primary outcome. "
03/01/2014 - "These were prospective and retrospective human studies presenting original data for participants with convulsive benzodiazepine-resistant status epilepticus. "
|9.||Kainic Acid (Kainate)IBA
03/05/2001 - "Kindling prior to a kainic acid challenge also provided substantial protection against status epilepticus-induced damage in the CA3 region of the hippocampus and piriform cortex in most animals. "
02/01/1988 - "Because kainic acid has been suggested as a model for human status epilepticus, CL 218-872 may be a potentially therapeutic treatment for this disorder."
01/01/2012 - "FVB.CAG140 mice are also resistant to neurodegeneration following kainic acid-induced status epilepticus suggesting the existence of a common cellular mechanism that provides protection against multiple types of excitotoxic insult. "
01/01/2011 - "Using pharmacological tools and two transgenic mice deficient for Panx1 we show here that interference with Panx1 ameliorates the outcome and shortens the duration of kainic acid-induced status epilepticus. "
11/02/2015 - "In the present study, we examined the effects of endurance training on susceptibility to kainate (KA)-induced status epilepticus (SE), behavioral changes and neuronal damage in spontaneously hypertensive rats (SHRs). "
02/01/2006 - "The purpose of this study is to report the case of a patient with normal lithium serum levels who developed non-convulsive status epilepticus (NCSE). "
01/01/2014 - "Nonconvulsive status epilepticus and Creutzfeldt-Jakob-like EEG changes in a case of lithium toxicity."
02/01/2008 - "Lithium overdose causing non-convulsive status epilepticus: the importance of lithium levels and the electroencephalography in diagnosis."
12/01/2007 - "We report a case of lithium overdose in a patient who presented in non-convulsive status epilepticus. "
12/01/2007 - "Lithium overdose causing non-convulsive status epilepticus--the importance of lithium levels and the electroencephalography in diagnosis."
|1.||Drug Therapy (Chemotherapy)
09/01/2015 - "Pharmacotherapy of status epilepticus, especially of its later stages, represents an "evidence-free zone," due to a lack of high-quality, controlled trials to inform clinical decisions. "
11/01/2011 - "Our literature review revealed >249 cases that share several main features: febrile illness with no preceding condition, negative laboratory studies including cerebrospinal fluid (CSF) analysis, status epilepticus refractory to conventional pharmacotherapy, and long-term developmental delays. "
09/01/2015 - "Pharmacotherapy for Status Epilepticus."
02/12/2013 - "Better treatment of status epilepticus (SE), which typically becomes refractory after about 30 min, will require new pharmacotherapies. "
09/01/2012 - "These findings may inform decision making on drug therapy in status epilepticus and help develop safer and more effective treatment strategies to improve outcome."
12/01/2012 - "[Intramuscular or intravenous inaugural injections for status epilepticus?]."
01/01/2012 - "Status epilepticus (SE) was induced (N = 13) by low-dose injections of KA, while controls (N = 9) received saline. "
01/01/1985 - "Bilateral injections of large doses of both gamma-aminobutyrate antagonists (2-3 nmol) resulted in the status epilepticus. "
12/02/1966 - "Biweekly injections led to status epilepticus. "
02/01/2011 - "Seventy-six percent of all animals receiving H-PILO injections had continuous seizures called status epilepticus (SE). "
12/01/2015 - "The ketogenic diet is an effective and well-tolerated treatment option for patients with refractory myoclonic status epilepticus and should be considered earlier in the course of treatment. "
02/01/2015 - "Recent reports have promoted the use of the ketogenic diet as an effective treatment for refractory status epilepticus. "
12/01/2015 - "Between May 1, 2014 and January 1, 2015, two patients who met the diagnostic criteria for refractory myoclonic status epilepticus, seen at our department, were placed on the ketogenic diet and followed for a minimum of six months. "
12/01/2015 - "We describe two patients with refractory myoclonic status epilepticus treated with the ketogenic diet. "
12/01/2015 - "The ketogenic diet in two paediatric patients with refractory myoclonic status epilepticus."
03/01/2013 - "When status epilepticus continues or recurs 24 hours or more after the initiation of anesthetic therapy, or recurs on the reduction or withdrawal of anesthesia, it is termed super RSE. "
11/01/2012 - "Possibly lifesaving, noninvasive, EEG-guided neuromodulation in anesthesia-refractory partial status epilepticus."
01/01/2007 - "Chaos theory and the treatment of refractory status epilepticus: Who benefits from prolonged anesthesia, and is there a better way?"
11/01/2005 - "Electroencephalogram monitoring is essential to evaluate the electrophysiologic treatment response and depth of anesthesia, especially in refractory status epilepticus. "
05/01/1969 - "[Anesthesia and muscle relaxants in the complex treatment of status epilepticus]."
10/01/2013 - "At the time of EEG, a continuous intravenous infusion (cIV) of an anticonvulsant drug was used to treat refractory status epilepticus (RSE). "
08/16/1999 - "Given at 20 mg/kg as single dose and with maintenance rate of 1 mg/kg/hour by intravenous infusion in 19 paediatric patients (1 day-7 years) status epilepticus was controlled in 58%, with reduction of status in 26%. "
05/01/2013 - "A comparative assessment the efficacy of intravenous infusion of sodium valproate and phenytion in the treatment of status epilepticus."
07/01/1998 - "[Efficacy of continuous intravenous infusion of midazolam in the treatment of status epilepticus in children]."
11/01/2009 - "A 9-year-old girl was treated with high-dose, continuous intravenous infusion of midazolam for the management of refractory status epilepticus. "