|1.||Kourounakis, Angeliki P: 3 articles (03/2014 - 12/2007)|
|2.||Ishibashi, Shun: 2 articles (05/2015 - 09/2006)|
|3.||Kitamine, Tetsuya: 2 articles (05/2015 - 09/2006)|
|4.||Tozawa, Ryuichi: 2 articles (05/2015 - 08/2007)|
|5.||Okazaki, Hiroaki: 2 articles (05/2015 - 09/2006)|
|6.||Yagyu, Hiroaki: 2 articles (05/2015 - 09/2006)|
|7.||Sekiya, Motohiro: 2 articles (05/2015 - 09/2006)|
|8.||Tazoe, Fumiko: 2 articles (05/2015 - 09/2006)|
|9.||de Souza, Wanderley: 2 articles (05/2014 - 01/2011)|
|10.||Urbina, Julio A: 2 articles (05/2014 - 01/2011)|
|1.||Hepatocellular Carcinoma (Hepatoma)
05/29/2003 - "Among these compounds, (Z)-3-[2-(9H-fluoren-2-yloxy)ethylidene]-quinuclidine hydrochloride 31 was found to be a potent inhibitor of squalene synthase derived from hamster liver and human hepatoma cells with IC(50) values of 76 and 48 nM, respectively. "
06/05/1992 - "Subcellular localization of squalene synthase in human hepatoma cell line Hep G2."
08/15/2003 - "Among the novel compounds, (Z)-2-[2-(quinuclidin-3-ylidene)ethoxy]-9H-carbazole hydrochloride 8 (YM-53579) and (E)-2-[2-fluoro-2-(quinuclidin-3-ylidene)ethoxy]-9H-carbazole hydrochloride 28 (YM-53601) were potent inhibitors of squalene synthase derived from human hepatoma cells, with IC(50) values of 160 and 79 nM, respectively. "
02/22/2002 - "Squalestatin1 (SQ1), a potent inhibitor of squalene synthase produced a dose-dependent induction of cytochromes P450 CYP2H1 and CYP3A37 mRNAs in chicken hepatoma cells. "
03/14/1989 - "Regulation of squalene synthetase in human hepatoma cell line Hep G2 by sterols, and not by mevalonate-derived non-sterols."
08/01/1997 - "Taken together, our results suggest that the discordant regulation of HMG-CoA reductase and squalene synthase during the host response to infection and inflammation may have substantial effects on the regulation of substrate flux into the non-sterol pathways of mevalonate metabolism."
11/01/2004 - "This article summarises novel developments in the lipid-altering therapies under development, including combination therapies, squalene synthase inhibitors, microsomal transfer protein inhibitors, acyl-cholesterol acyl transferase inhibitors, cholesterol ester transfer protein antagonists, peroxisome proliferator-activated receptor agonists, high-density lipoprotein-derived peptides and inflammation inhibitors, which have at least reached trials in animal models. "
09/01/1995 - "Direct in vitro enzyme studies with membrane fractions from primary cultures of embryonic rat brain (IC50 = 37 nM), pig brain (IC50 = 21 nM), and C6 glioma cells (IC50 = 35 nM) demonstrated that SQ potently inhibited squalene synthase activity but had no effect on the long-chain cis-isoprenyltransferase catalyzing the conversion of F-P-P to polyprenyl pyrophosphate (Poly-P-P), the precursor of dolichyl phosphate (Dol-P). "
05/10/2011 - "Lapaquistat acetate is a squalene synthase inhibitor investigated for the treatment of hypercholesterolemia. "
05/10/2011 - "Lapaquistat acetate: development of a squalene synthase inhibitor for the treatment of hypercholesterolemia."
01/01/2009 - "In particular, we investigate their role in the regulation of cellular and plasma cholesterol levels, including data that suggest that squalene synthase may be involved in the etiology of hypercholesterolemia."
12/01/2007 - "Chlorogenic acid inhibited the squalene synthase of pig liver with an IC50 level of 100 nM. Since chlorogenic acid was an effective inhibitor against the squalene synthase of an animal source, it may be a potential therapeutic agent for hypercholesterolemia."
09/01/2006 - "Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver."
09/15/2014 - "Squalene synthase (SQS) was up-regulated in CL1-5 cells and in the tumor regions of the lung cancer specimens. "
06/29/2007 - "Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation."
07/01/2013 - "We evaluated the expression of three lipid synthesis/processing protein markers alpha/beta hydrolase domain-containing protein 5 (ABHD5), progesterone receptor membrane component-1 (PGRMC1) and squalene synthase (SQS) in sebaceous carcinoma and investigated their utility in differentiating sebaceous tumors from BCC with clear cell features. "
09/30/2007 - "A full-length cDNA encoding squalene synthase (designated as TcSqS) was isolated from Taxus cuspidata, a kind of important medicinal plants producing potent anti-cancer drug, taxol. "
10/13/1998 - "We investigated the candidate cancer-related gene CTSB, and potential coamplified genes from this region including farnesyl-diphosphate farnesyltransferase (FDFT1), arylamine N-acetyltransferase (NAT-1), lipoprotein lipase (LPL), and an uncharacterized expressed sequence tag (D8S503). "
|2.||Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)
|9.||dolichol monophosphate (dolichyl phosphate)
|10.||1- ((1- (3- acetoxy- 2,2- dimethylpropyl)- 7- chloro- 5- (2,3- dimethoxyphenyl)- 2- oxo- 1,2,3,5- tetrahydro- 4,1- benzoxazepin- 3- yl)acetyl)piperidine- 4- acetic acid