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Farnesyl-Diphosphate Farnesyltransferase (Squalene Synthase)

The first committed enzyme of the biosynthesis pathway that leads to the production of STEROLS. it catalyzes the synthesis of SQUALENE from farnesyl pyrophosphate via the intermediate PRESQUALENE PYROPHOSPHATE. This enzyme is also a critical branch point enzyme in the biosynthesis of ISOPRENOIDS that is thought to regulate the flux of isoprene intermediates through the sterol pathway.
Also Known As:
Squalene Synthase; Squalene Synthetase; FPP-FPP Farnesyl Transferase; Farnesyldiphosphate-Farnesyldiphosphate Farnesyltransferase; Presqualene-Diphosphate Synthase; FPP FPP Farnesyl Transferase; Farnesyl Diphosphate Farnesyltransferase; Farnesyl Transferase, FPP-FPP; Farnesyldiphosphate Farnesyldiphosphate Farnesyltransferase; Farnesyltransferase, Farnesyl-Diphosphate; Farnesyltransferase, Farnesyldiphosphate-Farnesyldiphosphate; Presqualene Diphosphate Synthase; Synthase, Presqualene-Diphosphate; Synthase, Squalene; Synthetase, Squalene; Transferase, FPP-FPP Farnesyl
Networked: 45 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Kourounakis, Angeliki P: 3 articles (03/2014 - 12/2007)
2. Ishibashi, Shun: 2 articles (05/2015 - 09/2006)
3. Kitamine, Tetsuya: 2 articles (05/2015 - 09/2006)
4. Tozawa, Ryuichi: 2 articles (05/2015 - 08/2007)
5. Okazaki, Hiroaki: 2 articles (05/2015 - 09/2006)
6. Yagyu, Hiroaki: 2 articles (05/2015 - 09/2006)
7. Sekiya, Motohiro: 2 articles (05/2015 - 09/2006)
8. Tazoe, Fumiko: 2 articles (05/2015 - 09/2006)
9. de Souza, Wanderley: 2 articles (05/2014 - 01/2011)
10. Urbina, Julio A: 2 articles (05/2014 - 01/2011)

Related Diseases

1. Hepatocellular Carcinoma (Hepatoma)
2. Inflammation
3. Glioma (Gliomas)
4. Hypercholesterolemia
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Cholesterol
2. Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)
3. Enzymes
4. Lipoproteins (Lipoprotein)
5. Transferases
6. Peptides
7. Anticholesteremic Agents
8. cis-isoprenyltransferase
9. dolichol monophosphate (dolichyl phosphate)
10. 1- ((1- (3- acetoxy- 2,2- dimethylpropyl)- 7- chloro- 5- (2,3- dimethoxyphenyl)- 2- oxo- 1,2,3,5- tetrahydro- 4,1- benzoxazepin- 3- yl)acetyl)piperidine- 4- acetic acid

Related Therapies and Procedures

1. Therapeutics