Tropical Sprue

A chronic malabsorption syndrome, occurring mainly in residents of or visitors to the tropics or subtropics. The failed INTESTINAL ABSORPTION of nutrients from the SMALL INTESTINE results in MALNUTRITION and ANEMIA that is due to FOLIC ACID deficiency.

Also Known As:

Networked: 216 relevant articles (5 outcomes, 18 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Celiac Disease (Celiac Sprue)
2.	Steatorrhea
3.	Malnutrition (Nutritional Deficiencies)
4.	Lactose Intolerance (Intolerance, Lactose)
5.	Gastroenteritis

Experts

1.	Ghoshal, Uday C: 4 articles (10/2017 - 05/2003)
2.	Murray, Joseph A: 2 articles (10/2012 - 09/2003)
3.	Misra, Asha: 2 articles (03/2006 - 05/2003)
4.	Choudhury, Lopamudra: 1 article (05/2022)
5.	Nag, Sagnik: 1 article (05/2022)
6.	Roy, Souvik: 1 article (05/2022)
7.	Saini, Ankita: 1 article (05/2022)
8.	Amisha, Fnu: 1 article (01/2021)
9.	Biyani, Shubham: 1 article (01/2021)
10.	Gautam, Nitesh: 1 article (01/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Tropical Sprue:

1.	Folic Acid (Vitamin M)FDA LinkGeneric 12/23/1949 - "[Contribution to the clinicoradiologic study of the small intestine in tropical sprue; with reference to the treatment with folic acid]." 09/01/1946 - "Roentgenologic studies on the effect of synthetic folic acid on the gastrointestinal tract of patients with tropical sprue." 02/01/2004 - "Treatment of tropical sprue with folic acid replacement was introduced more than 50 years ago and has become standard medical treatment. " 11/22/1986 - "In 27 Puerto Rican patients with tropical sprue proven by intestinal biopsy and clinical response to folic acid, HLA type was determined with a microcytotoxicity assay. " 08/01/1976 - "In tropical sprue, folate malabsorption is the reflection of impaired folate transport and not of impaired hydrolysis."
2.	Tetracycline (Achromycin)FDA LinkGeneric 01/11/1975 - "Since clinical and biochemical improvement only occurred on treatment with tetracycline when enterobacteria were eliminated from the mucosa, it is suggested that these organisms may be responsible for persisting jejunal abnormalities in tropical sprue." 01/01/2001 - "Four of the seven patients who were misdiagnosed as tropical sprue were treated with tetracycline. " 12/02/2000 - "Various investigations were negative and led to the assumption of tropical sprue, which was treated with tetracycline. " 01/01/1975 - "Patients with the tropical sprue syndrome responded equally well clinically and biochemically to folate and tetracycline. " 09/01/1966 - "Folate repletion associated with oral tetracycline therapy in tropical sprue."
3.	Anti-Bacterial Agents (Antibiotics)IBA 07/01/2017 - "As both IBS, particularly the subset probably associated with SIBO, and tropical sprue improve with antibiotic treatment, we provide evidence and an explanatory model to support a link among these disorders." 05/01/2003 - "In tropical sprue (TS), response to antibiotics may suggest a role for bacterial contamination of the small bowel, which is known in diseases with prolonged orocecal transit time (OCTT). " 05/01/1981 - "Antibiotic-responsive malabsorption: a tropical sprue-like syndrome in countries with temperate climates." 02/01/1972 - "Long-term follow-up of antibiotic-treated tropical sprue." 10/01/1965 - "Long-term antibiotic therapy in tropical sprue."
4.	LactaseIBA 04/01/1968 - "Persistent deficiency of intestinal lactase in apparently cured tropical sprue."
5.	Vitamin DFDA LinkGeneric 03/01/1985 - "These results showed rapid clearance of the D3-3H in the subject with tropical sprue and steatorrhea indicating depletion of vitamin D stores in the tissues and decrease in the net absorption of the dose when given orally. "
6.	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 02/01/1976 - "Assessment of vitamin B12 absorption in tropical sprue utilizing a whole body counter." 09/01/1972 - "Vitamin B 12 and tropical sprue." 09/01/1962 - "Absorption of vitamin B12 in tropical sprue." 12/21/1961 - "Tropical sprue and vitamin B12." 01/01/1952 - "The comparative effect of vitamin B12 administered through different routes in tropical sprue."
7.	Bile Acids and Salts (Bile Acids)IBA 01/01/1971 - "Studies on bile salt deconjugation in patients with tropical sprue." 04/01/1974 - " is suggested that bile salt concentrations may be reduced in the proximal small intestine of patients with tropical sprue as a result of excessive dilution by intestinal fluid. " 04/01/1974 - "Mean and peak jejunal bile salt concentrations during digestion of a standard fat meal were found to be significantly lower in six Puerto Rican patients with untreated tropical sprue, all of whom had steatorrhoea, than in six asymptomatic subjects who had normal fat absorption. " 04/01/1974 - "Bile salt metabolism in tropical sprue." 06/01/1973 - "The increased rate of loss, and non-exponential excretion of bile salts in patients with tropical sprue and ileoctomy."
8.	CarbohydratesIBA 06/01/1966 - "Carbohydrate studies in tropical sprue." 08/01/1965 - "Carbohydrate studies in tropical sprue."
9.	Proteins (Proteins, Gene)FDA Link 04/01/1979 - "An experimental model resembling so-called tropical sprue has been produced in young, growing rhesus monkeys kept on a protein-deficient diet. " 04/01/1979 - "It appears, therefore, that protein malnutrition plays an important role in the experimental tropical-sprue-like syndrome in monkeys." 10/01/1977 - "Weight loss was equally prominent in those patients with tropical sprue who had normal absorption of fat and protein as in those who had excessive fecal loss and reduced absorption of these nutrients. " 06/01/1972 - "Tropical sprue versus protein malnutrition." 06/01/2005 - "Increased IELs in small bowel mucosa have also been associated with autoimmune disorders, tropical sprue, food protein intolerance, Helicobacter pylori-associated gastritis, peptic duodenitis, parasitic and viral infections, as well as the development of intestinal lymphoma. "
10.	AlbuminsIBA 12/01/1977 - "Distribution and degradation of albumin in tropical sprue--multivariate statistical analysis of parameters derived from turnover studies." 06/01/1973 - "The distribution and degradation of albumin in tropical sprue. " 01/01/1965 - "ALBUMIN METABOLISM IN TROPICAL SPRUE." 02/01/1969 - "Metabolism of albumin and fibrinogen in patients with tropical sprue." 01/01/1969 - "Influence of parenteral L-isomeric amino acids on absolute albumin synthesis rates in tropical sprue."

Therapies and Procedures

1.	Therapeutics 05/24/1956 - "[Gluten-free diet in therapy of idiopathic steatorrhea (non-tropical sprue)]." 10/01/2012 - "Immunodeficiency states, including HIV enteropathy, adult autoimmune enteropathy, drug-associated enteropathy, and tropical sprue continue to occur and require specific therapy. " 07/01/1969 - "Tween 80 therapy in tropical sprue." 10/01/1965 - "Long-term antibiotic therapy in tropical sprue." 09/01/1958 - "Long-term or maintenance adrenal steroid therapy in non-tropical sprue."
2.	Gluten-Free Diet 05/24/1956 - "[Gluten-free diet in therapy of idiopathic steatorrhea (non-tropical sprue)]." 04/21/1955 - "[Gluten-free diet in idiopathic steatorrhea; two cases of celiac disease and one of non-tropical sprue]." 04/01/2006 - "If a patient is not responding well to a gluten-free diet, three considerations are necessary: (1) the initial diagnosis of celiac disease must be reassessed;(2) the patient should be sent to a dietician to check for errors in diet or compliance problems, because problems with the gluten-free diet are the most important cause for persisting symptoms; (3) other reasons for persisting symptoms (eg, pancreatic insufficiency, irritable bowel syndrome, bacterial overgrowth, lymphocytic colitis, collagenous colitis, ulcerative jejunitis, protein-losing enteropathy,T-cell lymphoma, fructose intolerance, cavitating lymphadenopathy, and tropical sprue) should be considered. " 12/01/1985 - "Tropical sprue is cured by treatment with tetracycline and folic acid, whereas nontropical sprue responds to a gluten-free diet. "
3.	Drug Therapy (Chemotherapy) 07/01/1956 - "Tropical sprue; a study of seven cases and their response to combined chemotherapy."
4.	Oral Administration 03/01/1985 - "The presence of a higher percentage of the dose in the plasma as HCC-3H after the intravenous and oral administrations in the tropical sprue subjects when compared to controls indicates that the diseased state does not alter vitamin D3 metabolism." 02/01/1952 - "The oral administration of vitamin B12 in tropical sprue." 09/01/1953 - "[Oral administration of vitamin B12 labeled with cobalt60; its elimination in tropical sprue, in liver cirrhosis and in normal subjects]." 11/01/1951 - "Oral administration of vitamin B12 concentrate in tropical sprue and nutritional macrocytic anemia." 05/01/1951 - "[Effect of oral administration in sub-minimal doses of vitamin B12 and folic acid in tropical sprue]."
5.	Aftercare (After-Treatment) 07/16/1992 - "A 76-year-old woman with recurrent diarrhea several months after treatment for tropical sprue." 02/01/2013 - "The authors report two cases of American residents living in Thailand and Vietnam who had been suffering from chronic diarrhea, weight loss, being easily fatigued and nutritional deficiency and who dramatically responded after treatment for tropical sprue. " 02/01/1966 - "Anemia due to vitamin B12 deficiency after treatment with folic acid in tropical sprue."