Sphingomyelins

A class of sphingolipids found largely in the brain and other nervous tissue. They contain phosphocholine or phosphoethanolamine as their polar head group so therefore are the only sphingolipids classified as PHOSPHOLIPIDS.

Also Known As:

Networked: 1514 relevant articles (28 outcomes, 144 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jiang, Xian-Cheng: 16 articles (11/2019 - 02/2005)
2.	Schuchman, Edward H: 15 articles (10/2021 - 07/2002)
3.	Duan, Rui-Dong: 15 articles (02/2018 - 02/2002)
4.	Okazaki, Toshiro: 9 articles (11/2021 - 08/2011)
5.	Park, Tae-Sik: 8 articles (01/2022 - 11/2004)
6.	Liebisch, Gerhard: 8 articles (10/2021 - 05/2013)
7.	Albi, Elisabetta: 8 articles (10/2021 - 01/2015)
8.	Thurberg, Beth L: 8 articles (09/2020 - 05/2009)
9.	Li, Zhiqiang: 8 articles (12/2016 - 07/2005)
10.	Nilsson, Ake: 8 articles (03/2010 - 02/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1992 - "Neutral sphingomyelin vesicles with 67-Ga-labelled aqueous phase offer promise in scintigraphic imaging of tumors." 04/05/2022 - "Before in vivo studies: In vitro screening of sphingomyelin nanosystems using a relevant 3D multicellular pancreatic tumor spheroid model." 01/01/1997 - "The objective of this study was to determine whether chemically synthesized sphingomyelin reduces the appearance of ACF, one of the earliest morphological changes in the development of colonic tumors, and to investigate the specificity of this inhibition for the unsaturated sphingoid base backbone. " 07/12/2023 - "Sphingomyelin (SM) and its metabolites are crucial regulators of tumor cell growth, differentiation, senescence, and programmed cell death. " 10/31/2021 - "Cell surface biochemical changes, notably excessive increase in outer leaflet sphingomyelin (SM) content, are important in cancer initiation, growth, and immune evasion. "
2.	Niemann-Pick Diseases (Niemann Pick Disease) 01/01/1988 - "Epstein-Barr virus-transformed lymphoid cell lines from normal individuals and from patients with Niemann-Pick disease types A, B or C were subjected to various culture conditions in order to study the source of the characteristic lysosomal storage of sphingomyelin observed in the tissues of Niemann-Pick patients. " 01/01/2023 - "Acid sphingomyelinase deficiency (ASMD) is an autosomal recessive disease caused by biallelic pathogenic variants in the sphingomyelin phosphodiesterase-1 (SMPD1) gene. " 01/01/2023 - "Acid sphingomyelinase deficiency (ASMD), previously known as Niemann Pick A/B disease, is also an autosomal recessive lysosomal storage disorder due to mutations in the SMPD1 gene, which result in acid sphingomyelinase deficiency and the accumulation of sphingomyelin in mononuclear phagocytic system and hepatocytes. " 01/01/2023 - "Sphingomyelin 16:0 is a therapeutic target for neuronal death in acid sphingomyelinase deficiency." 01/01/2023 - "Niemann-Pick disease fibroblasts with a higher concentration of sphingomyelin exhibited lower TF activity compared with wild-type fibroblasts. "
3.	Dyslipidemias (Dyslipidemia) 08/22/2022 - "Vitamin D deficiency and dyslipidemia have a deep impact on sphingomyelins profile. " 01/01/2020 - "Milk sphingomyelin (SM), a polar lipid (PL) component of milk fat globule membranes, is protective against dyslipidemia. " 01/01/2018 - "In vivo ceramide reduction by inhibition of de novo ceramide synthesis reduced PLIN2 and hepatic steatosis in alcohol-fed mice, but only de novo synthesis inhibition, not sphingomyelin hydrolysis, improved glucose tolerance and dyslipidemia. " 01/01/2015 - "Since plasma ceramides are increased in NAFLD and sphingomyelin, a ceramide metabolite, is an independent risk factor for CVD, the role of ceramides in dyslipidemia was assessed using LDLR(-/-) mice, a diet-induced model of NAFLD and atherosclerosis. " 01/01/2020 - "Women who were underweight-associated sPTB also showed evidence of dyslipidemia characterized by elevated phospholipids, unsaturated triglycerides, sphingomyelins, cholesteryl esters and long-chain acylcarnitines. "
4.	Inflammation (Inflammations) 12/01/2019 - "Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin." 01/01/2017 - "Dietary sphingomyelin attenuates hepatic steatosis and adipose tissue inflammation in high-fat-diet-induced obese mice." 01/01/2011 - "The findings provide evidence that dietary sphingomyelin may increase intestinal inflammation." 01/01/2011 - "Dietary sphingomyelin in the IL-10(-/-) model confirmed aggravation of mucosal inflammation. " 08/01/2001 - "Sphingomyelin: a natural modulator of membrane homeostasis and inflammation."
5.	Cardiovascular Diseases (Cardiovascular Disease) 03/01/2010 - "A high plasma sphingomyelin level is not associated with an increased risk of incident CHD in population-based adults free of clinical cardiovascular disease at baseline." 05/15/2006 - "These observations are consistent with the hypothesis that plasma sphingomyelin is in the biologic pathway that mediates the risk for subclinical disease attributable to standard cardiovascular disease risk factors." 05/15/2006 - "Women with sphingomyelin levels of 60 or more mg/dl had more severe subclinical disease by all three measures than did the referent group with sphingomyelin levels of 39 or less mg/dl, although associations were not significant after multivariate adjustment for standard cardiovascular disease risk factors. " 07/07/2022 - "Circulating Palmitoyl Sphingomyelin Is Associated With Cardiovascular Disease in Individuals With Type 2 Diabetes: Findings From the China Da Qing Diabetes Study. " 03/01/2022 - "Circulating Palmitoyl Sphingomyelin Is Associated With Cardiovascular Disease in Individuals With Type 2 Diabetes: Findings From the China Da Qing Diabetes Study."

Related Drugs and Biologics

1.	Lipids
2.	Phosphatidylcholines (Phosphatidylcholine)
3.	Cholesterol
4.	Sphingomyelin Phosphodiesterase (Sphingomyelinase)
5.	Phospholipids (Phosphatides)
6.	Liposomes (Liposome)
7.	Fatty Acids (Saturated Fatty Acids)
8.	olipudase alfa
9.	Arachidonic Acid (Vitamin F)
10.	Vincristine (Oncovin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Glycemic Control
4.	Carbohydrate-Restricted Diet (Low Carbohydrate Diet)
5.	Tocolysis