|1.||Schuchman, Edward H: 35 articles (07/2014 - 05/2002)|
|2.||Gulbins, Erich: 32 articles (01/2016 - 12/2002)|
|3.||Hannun, Yusuf A: 14 articles (06/2015 - 06/2004)|
|4.||Schuchman, E H: 11 articles (01/2009 - 08/2000)|
|5.||Zhang, Yang: 10 articles (01/2016 - 09/2008)|
|6.||Grassmé, Heike: 10 articles (06/2015 - 12/2002)|
|7.||He, Xingxuan: 10 articles (07/2014 - 07/2002)|
|8.||Duan, Rui-Dong: 10 articles (02/2013 - 07/2002)|
|9.||Schütze, Stefan: 9 articles (01/2014 - 02/2004)|
|10.||Becker, Katrin Anne: 8 articles (06/2015 - 11/2008)|
|1.||Niemann-Pick Diseases (Niemann Pick Disease)
10/01/2000 - "Hematopoietic stem cell gene therapy leads to marked visceral organ improvements and a delayed onset of neurological abnormalities in the acid sphingomyelinase deficient mouse model of Niemann-Pick disease."
05/01/2009 - "Pulmonary delivery of recombinant acid sphingomyelinase improves clearance of lysosomal sphingomyelin from the lungs of a murine model of Niemann-Pick disease."
01/01/1999 - "Fluorescence-based selection of gene-corrected hematopoietic stem and progenitor cells from acid sphingomyelinase-deficient mice: implications for Niemann-Pick disease gene therapy and the development of improved stem cell gene transfer procedures."
01/05/2001 - "Although studies using lymphoblasts from Niemann-Pick disease patients or acid sphingomyelinase (ASMase)-deficient mice have provided genetic support for this hypothesis, these models have not been universally accepted as definitive. "
09/01/1987 - "Transitory type of sphingomyelinase deficient Niemann-Pick disease: clinical and morphological studies and follow-up of two sisters."
10/01/2013 - "Accordingly, Hsp70, which supports cancer cell survival by increasing lysosomal acid sphingomyelinase activity, conferred partial protection against SU11652-induced cytotoxicity. "
10/01/2015 - "Activation of acid sphingomyelinase (ASM) leads to ceramide accumulation and induces apoptotic cell death in cancer cells. "
09/15/2015 - "New oleyl glycoside as anti-cancer agent that targets on neutral sphingomyelinase."
07/01/2015 - "The toxicity of both compounds was associated with efficient lipid uptake into the tumor cells and activation of acid sphingomyelinase. "
09/09/2013 - "Here, we identify acid sphingomyelinase (ASM) inhibition as a selective means to destabilize cancer cell lysosomes. "
01/01/2014 - "Aim of this study was to evaluate the impact of neutral sphingomyelinase (nSMase) inhibition on saturated fatty acid induced lipotoxicity and insulin resistance in skeletal muscle myotubes. "
03/27/2009 - "Acid sphingomyelinase plays important roles in ceramide homeostasis, which has been proposed to be linked to insulin resistance. "
01/01/2015 - "[ROLE OF NEUTRAL SPHINGOMYELINASE IN AGE-DEPENDENT MUSCLE INSULIN RESISTANCE DEVELOPMENT AND ITS IMPROVEMENT WITH N-ACETYLCYSTEINE]."
04/01/2012 - " High fat diet feeding caused NAFLD with peripheral and hepatic insulin resistance, increased hepatic expression of pro-ceramide genes, sphingomyelinase activity, and lipid peroxidation, and increased serum ceramide. "
01/01/2004 - "Ceramides, either generated via activation of sphingomyelinase or produced by de novo synthesis, induce insulin resistance in cultured cells by inhibitory effects on insulin signaling. "
06/01/2010 - "Bacillus cereus sphingomyelinase (Bc-SMase) induces hemolysis of sheep erythrocytes which contain large amounts of sphingomyelin. "
06/01/2010 - "Hemolysis induced by Bacillus cereus sphingomyelinase."
10/28/2008 - "We also interpret the slow hemolysis observed at 37 degrees C as a phenomenon of gradual release of aqueous contents, induced by the sphingomyelinase activity, as described by Ruiz-Arguello et al. [(1996) J. "
10/28/2008 - "Ceramide-enriched membrane domains in red blood cells and the mechanism of sphingomyelinase-induced hot-cold hemolysis."
12/01/2007 - "Structure-directed active site mutations show that biological activities, including hemolysis and lymphotoxicity, are due to the sphingomyelinase activity of the enzyme."
|5.||Breast Neoplasms (Breast Cancer)
04/01/2015 - "Neutral sphingomyelinase and breast cancer research."
10/01/2012 - "These results indicate that derivative-6 induced the activation of sphingomyelinase signaling and that JNK played a pivotal role in induction of apoptosis in human breast cancer cells. "
10/01/2012 - "Quinuclidinone derivative 6 induced apoptosis in human breast cancer cells via sphingomyelinase and JNK signaling."
03/01/2011 - "Based on previous results it is proposed that quinuclidinone derivative 8a provokes apoptosis in human breast cancer cells (MCF-7) via the sphingomyelinase pathway."
06/11/2004 - "Recently, we reported that neutral sphingomyelinase 2 (nSMase2) functions as a bona fide neutral sphingomyelinase and that overexpression of nSMase2 in MCF7 breast cancer cells caused a decrease in cell growth (Marchesini, N., Luberto, C., and Hannun, Y. "
|1.||Arachidonic Acid (Vitamin F)
|2.||neodymium pyrocatechin disulfonate (NPD)
|3.||Proteins (Proteins, Gene)
|5.||Phospholipases A2 (Phospholipase A2)
|6.||Lipid Bilayers (Lipid Bilayer)
|9.||Janus Kinase 3
|10.||Phospholipid Transfer Proteins
|1.||Drug Therapy (Chemotherapy)
|5.||Enzyme Replacement Therapy