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Sphingomyelin Phosphodiesterase (Sphingomyelinase)

An enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide (N-acylsphingosine) plus choline phosphate. A defect in this enzyme leads to NIEMANN-PICK DISEASE. EC 3.1.4.12.
Also Known As:
Sphingomyelinase; Sphingomyelinase C; Sphingomyelin Cholinephosphohydrolase; Sphingomyelin Cleaving Enzyme
Networked: 632 relevant articles (13 outcomes, 46 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Schuchman, Edward H: 35 articles (07/2014 - 05/2002)
2. Gulbins, Erich: 32 articles (01/2016 - 12/2002)
3. Hannun, Yusuf A: 14 articles (06/2015 - 06/2004)
4. Schuchman, E H: 11 articles (01/2009 - 08/2000)
5. Zhang, Yang: 10 articles (01/2016 - 09/2008)
6. Grassmé, Heike: 10 articles (06/2015 - 12/2002)
7. He, Xingxuan: 10 articles (07/2014 - 07/2002)
8. Duan, Rui-Dong: 10 articles (02/2013 - 07/2002)
9. Schütze, Stefan: 9 articles (01/2014 - 02/2004)
10. Becker, Katrin Anne: 8 articles (06/2015 - 11/2008)

Related Diseases

1. Niemann-Pick Diseases (Niemann Pick Disease)
2. Neoplasms (Cancer)
3. Insulin Resistance
4. Hemolysis
5. Breast Neoplasms (Breast Cancer)

Related Drugs and Biologics

1. Arachidonic Acid (Vitamin F)
2. neodymium pyrocatechin disulfonate (NPD)
3. Proteins (Proteins, Gene)
4. Phospholipids
5. Phospholipases A2 (Phospholipase A2)
6. Lipid Bilayers (Lipid Bilayer)
7. Glutaral (Glutaraldehyde)
8. Acetylcysteine (Siran)
9. Janus Kinase 3
10. Phospholipid Transfer Proteins

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Ligation
3. Transplants (Transplant)
4. Decompression
5. Enzyme Replacement Therapy