Sparganosis

Infection of animals, including fish and man, with a developmental stage of Diphyllobothrium. This stage has recently been referred to as a plerocercoid but the name sparganum has persisted. Therefore, infection of fish or other animals with the plerocercoid larvae is sparganosis. Fish-eating mammals, including man, are the final hosts.

Also Known As:

Networked: 92 relevant articles (9 outcomes, 12 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Cysticercosis
2.	Echinococcosis (Hydatid Cysts)
3.	Schistosomiasis (Bilharziasis)
4.	Infections
5.	Paragonimiasis

Experts

1.	Cui, Jing: 9 articles (05/2017 - 06/2011)
2.	Wang, Zhong Quan: 7 articles (02/2015 - 06/2011)
3.	Liu, Li Na: 5 articles (02/2015 - 07/2013)
4.	Zhang, Xi: 4 articles (05/2017 - 09/2014)
5.	Intapan, Pewpan M: 4 articles (07/2015 - 12/2011)
6.	Maleewong, Wanchai: 4 articles (07/2015 - 12/2011)
7.	Jiang, Peng: 4 articles (02/2015 - 06/2011)
8.	Kong, Yoon: 4 articles (01/2015 - 09/2002)
9.	Yang, Hyun-Jong: 4 articles (01/2015 - 06/2004)
10.	Yamasaki, Hiroshi: 4 articles (09/2014 - 12/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sparganosis:

1.	Praziquantel (Biltricide)FDA Link 10/01/2018 - "The efficacy of praziquantel treatment was similar to that of surgical lesion removal for cerebral sparganosis with respect to both the primary outcome and secondary outcomes. " 05/04/2017 - "This patient was primarily diagnosed as visceral sparganosis, and cured with praziquantel.Sparganosis" 10/01/2018 - "In this small-sample, nonrandomized, retrospective exploratory study, some patients with cerebral sparganosis were responsive to long-term, high-dose praziquantel with an efficacy similar to that of surgical lesion removal. " 08/27/2019 - "Although surgery is the preferred treatment for cerebral sparganosis, praziquantel might also achieve satisfying outcomes." 10/01/2018 - "In contrast, the efficacy and safety of long-term, high-dose praziquantel treatment for cerebral sparganosis have not been explored. "
2.	AntigensIBA 08/24/2021 - "mansoni has been successfully constructed and 4 categories of positive clones have been identified, which provides a basis for further studies on diagnostic antigens for sparganosis mansoni. " 12/01/2021 - "Clinical diagnosis of sparganosis is crucial for effective treatment, thus it is important to identify sensitive and specific antigens of plerocercoids. " 08/24/2021 - "To construct a cDNA library of Sparganum mansoni and immunoscreen antigen candidates for immunodiagnosis of sparganosis mansoni. " 02/01/2015 - "The results showed that the rSeCP might be a potential candidate antigen for early and specific serodiagnosis of sparganosis. " 01/01/2015 - "The rSeCP is a potential diagnostic antigen for sparganosis."
3.	ImmunosorbentsIBA 01/01/2011 - "Immunoserologic testing using enzyme linked immunosorbent assays can be helpful in diagnosing human sparganosis, especially in cases without a subcutaneous lump or mass. " 10/05/2016 - "A total of 216 serum samples from two rural districts, Monduli and Babati, were tested for sparganosis using an enzyme-linked immunosorbent assay. " 05/01/2016 - "Cerebrospinal fluid eosinophil counts and enzyme-linked immunosorbent assay for anti-sparganosis antibody and computed tomography/magnetic resonance imaging scans may be relied on for an early and accurate diagnosis before surgery." 05/01/2016 - "Enzyme-linked immunosorbent assay revealed that serum anti-sparganosis antibody was positive in 9 of 9 patients and cerebrospinal fluid anti-sparganosis antibody was positive in 4 of 6 patients. " 10/01/2007 - "Combined with clinical data and enzyme-linked immunosorbent assay, the preoperative diagnosis of cerebral sparganosis could be established on MR imaging."
4.	EnzymesIBA 01/01/2011 - "Immunoserologic testing using enzyme linked immunosorbent assays can be helpful in diagnosing human sparganosis, especially in cases without a subcutaneous lump or mass. " 10/05/2016 - "A total of 216 serum samples from two rural districts, Monduli and Babati, were tested for sparganosis using an enzyme-linked immunosorbent assay. " 05/01/2016 - "Cerebrospinal fluid eosinophil counts and enzyme-linked immunosorbent assay for anti-sparganosis antibody and computed tomography/magnetic resonance imaging scans may be relied on for an early and accurate diagnosis before surgery." 05/01/2016 - "Enzyme-linked immunosorbent assay revealed that serum anti-sparganosis antibody was positive in 9 of 9 patients and cerebrospinal fluid anti-sparganosis antibody was positive in 4 of 6 patients. " 10/01/2007 - "Combined with clinical data and enzyme-linked immunosorbent assay, the preoperative diagnosis of cerebral sparganosis could be established on MR imaging."
5.	Cysteine Proteases (Cysteine Protease)IBA 02/01/2014 - "Diagnostic efficacy of a recombinant cysteine protease of Spirometra erinacei larvae for serodiagnosis of sparganosis." 01/01/2015 - "The aim of this study was to characterize Spirometra erinaceieuropaei cysteine protease (SeCP) and to evaluate its potential application for serodiagnosis of sparganosis. " 03/01/2017 - "Here, we demonstrated the enzymatic property and involvement of a native 23kDa cysteine protease (Se23kCP), purified from plerocercoids, in sparganosis pathogenesis. " 02/01/2015 - "Serodiagnosis of sparganosis by ELISA using recombinant cysteine protease of Spirometra erinaceieuropaei spargana." 01/01/2015 - "Characterization of Spirometra erinaceieuropaei Plerocercoid Cysteine Protease and Potential Application for Serodiagnosis of Sparganosis."
6.	Albendazole (Albenza)FDA Link 02/29/2012 - "The results indicated albendazole has no obvious efficacy for treating sparganosis in mice." 12/01/2021 - "Although the surgical removal of larvae is known to be the best way of treatment for sparganosis, we administered the high-dosage of praziquantel, albendazole and dexamethasone to prevent the occurrence of another remain worms in this study."
7.	Immunoglobulin G (IgG)IBA 12/01/1989 - "The present study is intended to observe the chronologic changes of experimental sparganosis by histopathological observation and detection of circulating anti-sparganum IgG antibody using ELISA. " 05/21/2016 - "Moreover, the result of the immunoglobulin G antibody test for sparganosis was positive but became negative after endoscopic submucosal dissection. " 07/01/2015 - "IgG antibody tests for sparganosis were positive. " 09/01/2000 - "mansoni plerocercoid is the main antigenic component inducing IgG antibody response in early stage of experimental sparganosis and for specific IgG subclass reactions in human sparganosis." 09/01/2000 - "When 69 patients sera of human sparganosis were examined for their IgG subclass responses, IgG4 levels showed the highest reaction which was followed by IgG1. "
8.	AntibodiesIBA 01/01/2022 - "Along with the "tunnel sign" on MRI, cerebral sparganosis was suspected and confirmed by positive serum and cerebrospinal fluid antibodies against Spirometra mansoni. " 12/01/2018 - "Although the patient's serum was positive for sparganum antibodies, the diagnosis of sparganosis was not confirmed for more than three months. " 09/01/2014 - "Development of a rapid diagnostic kit that uses an immunochromatographic device to detect antibodies in human sparganosis." 03/01/1992 - "When polyclonal antibodies such as BALB/c mouse serum immunized with crude saline extract of sparganum or confirmed sparganosis sera were reacted as primary antibodies, the positive chromogen (3-amino, 9-ethylcarbazole) reactions were recognized at syncytial tegument, tegumental cells, muscle and parenchymal cells and lining cells of excretory canals. " 12/01/2013 - "Sparganosis was diagnosed by demonstration of the sparganum in histopathological sections of surgically resected tissues and also by the presence of serum IgG antibodies by ELISA. "
9.	feralIBA 06/12/2001 - "The primary objective of this study was the determination of the prevalence of gross sparganosis in Florida county of origin in slaughtered feral swine. " 06/01/2012 - "The occurrence of the cestode in feral cats coupled with factors that are unique to Grand Cayman makes this island the ideal location for sporadic cases of human sparganosis." 06/01/2012 - "The occurrence of platynosomiasis and intestinal sparganosis is described in feral cats from Grand Cayman, Cayman Islands. " 06/12/2001 - "Overall prevalence of sparganosis in Florida feral swine was 6.9%. " 06/12/2001 - "Tracebacks to county of origin were conducted for Florida feral swine with and without gross sparganosis. "
10.	Dexamethasone (Maxidex)FDA LinkGeneric 11/01/2013 - "Surgical therapy is optimal in the treatment for cerebral sparganosis, but medication (praziquantel and dexamethasone) has achieved favorable outcomes in some patients. " 12/01/2021 - "Although the surgical removal of larvae is known to be the best way of treatment for sparganosis, we administered the high-dosage of praziquantel, albendazole and dexamethasone to prevent the occurrence of another remain worms in this study."

Therapies and Procedures

1.	Therapeutics 06/01/2018 - "Surgical removal is effective for the treatment of perineal sparganosis, followed by a course of therapy." 06/01/2022 - "With awareness of the risk factors for cerebral sparganosis and consideration for this diagnosis when the response to therapy for other organisms appears suboptimal, the time to accurate diagnosis may be reduced, and treatment outcomes improved." 10/01/2018 - "Surgical removal of the larvae is considered a standard therapy for cerebral sparganosis. " 10/01/2013 - " experienced a case of sparganosis from a patient with lymphoma whose immune system was suppressed by anticancer therapy, suggesting that the immunosuppression might affect the onset and the exacerbation of the disease. " 06/01/2014 - "Oral praziquantel is effective for the treatment of sparganosis mansoni, although its course of therapy may need to be repeated. "
2.	Aftercare (After-Treatment) 08/01/2013 - "Thus, the patient was first diagnosed as sparganosis; however, new migratory swellings occurred after treatment with praziquantel for 3 days. " 01/01/2023 - "This study provided evidence that the serum IgG antibody level of sparganum was a promising biomarker to evaluate the prognosis of patients with cerebral sparganosis after treatment." 01/01/2023 - "The serum IgG antibody level as a biomarker for clinical outcome in patients with cerebral sparganosis after treatment."
3.	Oral Administration 05/07/2022 - "[Establishment of an animal model of Sparganum mansoni infection and study on therapeutic methods II Establishment of a mouse model of sparganosis mansoni via oral administration of procercoids]." 05/07/2022 - "A mouse model of sparganosis mansoni is successfully created through oral administration of Cyclops infected with Spirometra mansoni procercoids. " 05/07/2022 - "To establish an animal model of sparganosis mansoni through oral administration of Cyclops infected with procercoids. "
4.	Minimally Invasive Surgical Procedures 11/10/2022 - "Then, three segments of incomplete white worms were resected through minimally invasive surgery, and metagenomic sequencing revealed sparganosis mansoni. "
5.	Thrombectomy 06/01/2020 - "We report a case of cerebral intravascular sparganosis in an elderly patient with acute ischemic stroke who was diagnosed by retrieving sparganum during mechanical thrombectomy. "