Somatomedins (Somatomedin)

Insulin-like polypeptides made by the liver and some fibroblasts and released into the blood when stimulated by SOMATOTROPIN. They cause sulfate incorporation into collagen, RNA, and DNA synthesis, which are prerequisites to cell division and growth of the organism.

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Networked: 271 relevant articles (3 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cappellini, Maria Domenica: 3 articles (08/2016 - 11/2007)
2.	Cattaneo, Agnese: 3 articles (08/2016 - 11/2007)
3.	Cavagnini, Francesco: 3 articles (08/2016 - 11/2007)
4.	D'Angelo, Emanuela: 3 articles (08/2016 - 11/2007)
5.	Danesi, Leila: 3 articles (08/2016 - 11/2007)
6.	Mirra, Nadia: 3 articles (08/2016 - 11/2007)
7.	Scacchi, Massimo: 3 articles (08/2016 - 11/2007)
8.	Zanaboni, Laura: 3 articles (08/2016 - 11/2007)
9.	Argento, Crocetta: 2 articles (08/2008 - 11/2007)
10.	Carnelli, Vittorio: 2 articles (08/2008 - 11/2007)

Related Diseases

1.	Uremia 10/01/1978 - "Somatomedin's levels in uremia are variously reported. " 11/19/1976 - "Further efforts are necessary to identify the inhibitor(s) of somatomedin activity in uremia." 10/01/1984 - "These studies suggest that decreased circulating somatomedin activity and impaired growth in uremia may reflect the accumulation of a circulating peptide inhibitor that would normally be cleared by the kidneys. " 03/01/1983 - "Our findings are consistent with the hypothesis that somatomedin, like other polypeptide hormones, is elevated in uremia and that increased energy intake may affect the growth of children with chronic renal insufficiency by increasing somatomedin levels." 11/01/1986 - "Somatomedin levels measured by radioreceptor assay (RRA) or RIA on acid-ethanol-extracted or unextracted serum from patients with uremia are quite variable relative to normal values. "
2.	Breast Neoplasms (Breast Cancer) 01/01/1988 - "In patients with cancer of the breast, uterus and lung, a significant correlation was established between somatomedin activity, on the one hand, and monocyte. " 01/01/1988 - "In breast cancer patients, a relatively high blood--somatomedin level was mostly observed in solid forms, this being matched by relatively high somatomedin levels in tumor tissue. " 01/01/1980 - "It was shown that in patients with breast cancer and cancer of the corpus uteri in the presence of hypercholesterinemia and hypertriglyceridemia the level of blood somatomedin activity would be 3--5 times the control values, being 3.04 +/- 0.73% unit/ml in breast cancer patients and 2.20 +/- 0.61 unit/ml in those with endometrial cancer. " 01/01/1980 - "[Effect of phenformin and miscleron on the blood somatomedin activity level in breast cancer]." 01/01/1980 - "An antidiabetic drug phenformin (50--100 mg/day) as well as an antidiabetic drug miscleron (1--1.5 g/day), used during 7--24 weeks, were found to result in the reduced level of the somatomedin activity in breast cancer patients being in the stage of remission (1.94 +/- 0.36 unit/ml before the treatment, 0.94 +/- 0.17 unit/ml after it)."
3.	Pituitary Neoplasms (Pituitary Adenoma) 03/01/1982 - "Rat basic somatomedin (Sm) was prepared with an improved purification scheme from the pooled sera of Wistar Furth rats previously inoculated with cells from the pituitary tumor MStT/W15. " 09/01/1982 - "Male and female Wistar-Furth rats bearing the pituitary tumor MtT/W15 had serum GH and PRL levels several hundred-fold higher, and immunoreactive somatomedin levels 3-fold higher, than those of controls. " 06/01/1985 - "Regulation of growth hormone release from cultured human pituitary adenomas by somatomedins and insulin." 02/01/1977 - "We have purified a protein which has somatomedin-like properties from the serum of Wistar-Furth rats bearing a growth hormone producing pituitary tumor (MStT/W15). " 11/01/1985 - "Specific receptors for insulin and the somatomedin peptides insulin-like growth factors I and II (IGF-I and IGF-II) have been characterized on three separate cloned strains of rat pituitary tumor cells (GH3, GH1, and GC). "
4.	Neoplasms (Cancer) 01/01/1988 - "Blood somatomedin activity observed in patients with cancer of the corpus uteri, breast, colon and rectum, pancreas, ovary and lung proved to exceed those in control by 140-300%. " 01/01/1988 - "[Somatomedin activity of the blood: hormonal metabolic and immunological shifts in cancer patients]." 01/01/1988 - "It is suggested that there is a relationship between blood-somatomedin level in cancer patients and tumor mediated by somatomedin-like and -inhibiting factors produced by it." 01/01/1988 - "The tissue of 60% of large bowel tumors was shown to produce an inhibitor of somatomedin activity. " 01/01/1988 - "The effect of tumor on somatomedin level in blood was investigated. "
5.	Pituitary Dwarfism 09/01/1975 - "Pituitary dwarfism in german shepherd dogs: studies on somatomedin activity." 01/01/1976 - "Pituitary dwarfism is a genetically heterogeneous group of disorders associated with a variety of pathogenetic mechanisms which may involve any level of the hypothalamic-pituitary-somatomedin-peripheral tissue axis. " 07/01/1963 - "Sulfation factor measurement as an aid in the recognition of pituitary dwarfism." 10/20/1984 - "[Somatomedin (bioassay) response to long-term growth hormone treatment of idiopathic pituitary dwarfism]." 01/01/1981 - "Inasmuch as the medium was supplemented with 10% fetal calf serum, which presumably contains somatomedin, these data suggest that the Dw/Dw mutant cannot be considered simply a model for pituitary dwarfism. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Hypoglycemic Agents (Hypoglycemics)
3.	Phenformin (Fenformin)
4.	Clofibrate
5.	Growth Hormone (Somatotropin)
6.	Insulin-Like Growth Factor I (IGF-1)
7.	Insulin-Like Peptides
8.	Insulin-Like Growth Factor II (Somatomedin A)
9.	Insulin (Novolin)
10.	Glucose (Dextrose)

Related Therapies and Procedures

1.	Therapeutics
2.	Transplantation
3.	Protein-Restricted Diet (Diet, Protein Restricted)
4.	Ovariectomy (Oophorectomy)
5.	Lasers (Laser)