Soft Tissue Neoplasms

Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.

Also Known As:

Networked: 95 relevant articles (5 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Pain (Aches)
3.	Neurilemmoma (Schwannoma)
4.	Perivascular Epithelioid Cell Neoplasms
5.	Neurofibroma

Experts

1.	Thway, Khin: 6 articles (02/2016 - 06/2012)
2.	Fisher, Cyril: 5 articles (02/2016 - 06/2012)
3.	Agaimy, Abbas: 3 articles (01/2021 - 01/2016)
4.	Dickson, Brendan C: 3 articles (01/2021 - 06/2013)
5.	Al-Ibraheemi, Alyaa: 2 articles (08/2022 - 01/2021)
6.	Schaefer, Inga-Marie: 2 articles (05/2021 - 01/2021)
7.	Folpe, Andrew L: 2 articles (01/2021 - 01/2019)
8.	Haller, Florian: 2 articles (01/2021 - 01/2016)
9.	Jones, Robin L: 2 articles (02/2016 - 01/2016)
10.	Noujaim, Jonathan: 2 articles (02/2016 - 01/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Soft Tissue Neoplasms:

1.	DNA (Deoxyribonucleic Acid)IBA 12/01/1991 - "Fine needle aspiration specimens from 29 patients with bone and soft tissue neoplasms were analyzed by flow cytometry for DNA index and cell cycle analysis to determine whether such studies were helpful in cytologic diagnosis. " 11/01/1993 - "Development and optimization of tissue preparative methodology for DNA content analysis of soft tissue neoplasms." 01/01/1993 - "After optimizing the technique, the DNA content of 50 soft tissue neoplasms derived from FFPE specimens was compared to the corresponding fresh surgical tissue. " 06/15/1997 - "Flow cytometric DNA content analysis of 185 soft tissue neoplasms indicates that S-phase fraction is a prognostic factor for sarcomas. " 11/01/1993 - "Development and optimization of tissue specific preparative techniques for DNA flow cytometry was undertaken prior to routine DNA content analysis of soft tissue neoplasms; 154 soft tissue tumors were studied. "
2.	Monoclonal AntibodiesIBA 01/01/2023 - "There was a higher number of moderate adverse reactions (grade 2 according to the Common Terminology Criteria for Adverse Events Version 4.0) between the first and third chemotherapy cycles, with a latency period of between 6 and 15 min., generally lasting less than 30 min. Association with the degree of immediate adverse reaction (grade) has been observed in male subjects over 71 years of age, with soft tissue neoplasm type and monoclonal antibodies therapeutic group." 01/01/1986 - "The Leu-7 (HNK-1) monoclonal antibody, a hematological marker, has been found to cross-react with a number of cells of schwannian origin and may be helpful in the differential diagnosis of schwannomas and neurofibromas from other soft tissue neoplasms. "
3.	GalliumIBA 01/01/1992 - "The efficacy of gallium scintigraphy in detecting malignant soft tissue neoplasms."
4.	lipoarabinomannan (LAM)IBA 01/01/2022 - "Classified as a low-grade malignant soft tissue neoplasm from the family of perivascular epithelioid cell (PEC) tumors or PEComas, it is characterized by a proliferation of abnormal smooth muscle-like cells (LAM cells), coexpressing myogenic and melanocytic markers, with HMB45 as the gold-standard immunohistochemical diagnostic marker. "
5.	Proteins (Proteins, Gene)FDA Link 09/01/2018 - "Soft tissue neoplasms are diagnostically challenging, although many advances in ancillary testing now enable accurate classification of fine-needle aspiration biopsies by detection of characteristic immunophenotypes (including protein correlates of molecular alterations) and molecular features. " 06/01/2013 - "The purpose of this study was to use immunohistochemistry to characterize SIRT1 protein expression in human soft tissue neoplasms with the hopes of finding new diagnostic and therapeutic modalities. " 01/01/2023 - "Inflammatory myofibroblastic tumor (IMT) is an ultra-rare soft tissue neoplasm associated with fusion proteins encompassing the anaplastic lymphoma kinase (ALK) protein fused to a variety of partner proteins. "
6.	Gadolinium DTPA (Magnevist)FDA Link 10/01/1994 - "[Gadolinium-DTPA combined with a fat suppression technique in studies with magnetic resonance at 0.5 T in soft-tissue neoplasms]." 10/01/1994 - "We combined a modified three-point Dixon technique for fat suppression with gadolinium-DTPA administration in the investigation of soft tissue neoplasms at 0.5 T. " 01/01/1994 - "The technique was combined with intravenous administration of gadolinium-DTPA in five patients with lumbosacral spine conditions, four patients with soft tissue neoplasms and three with skeletal neoplasms; all patients were examined at 0.5 T. "
7.	Sirtuin 1IBA 06/01/2013 - "Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation." 06/01/2013 - "A similar pattern of cytoplasmic SIRT1 expression was observed in soft tissue neoplasms with myoid differentiation, namely, angiomyolipoma (100%), glomus tumor (100%), leiomyoma (90%), leiomyosarcoma (76.5%), and rhabdomyosarcoma (87%). " 06/01/2013 - "The purpose of this study was to use immunohistochemistry to characterize SIRT1 protein expression in human soft tissue neoplasms with the hopes of finding new diagnostic and therapeutic modalities. "
8.	inhibin-alpha subunitIBA 12/01/2003 - "However, no study to date has evaluated alpha-inhibin immunoreactivity in soft-tissue neoplasms, which frequently enter the differential diagnosis of retroperitoneal masses. " 12/01/2003 - "However, the rarity of alpha-inhibin expression by soft-tissue neoplasms provides further support for its overall specificity as a marker of adrenal cortical differentiation in the biopsy evaluation of a retroperitoneal mass." 12/01/2003 - "We investigate the incidence of alpha-inhibin staining in a variety of soft-tissue neoplasms by using formalin-fixed, paraffin-embedded tissue sections from 282 previously classified soft-tissue neoplasms with anti-alpha-inhibin (Serotec, 1:75). "
9.	copper pyruvaldehyde bis(N(4)-methylthiosemicarbazone) complexIBA 01/01/1994 - "To evaluate whether [62Cu]Cu-PTSM could also serve as a blood flow tracer in PET studies of tumor tissue, the tumor uptake of [62Cu]Cu-PTSM was examined in dogs with spontaneously-occurring soft-tissue neoplasms. "
10.	Keratins (Keratin)IBA 07/01/2023 - "It is therefore crucial to be aware of diagnostic pitfalls when encountering cytokeratin positivity in superficial soft tissue neoplasms. " 01/01/2021 - "We present six distinctive giant cell-rich soft tissue neoplasms that expressed keratins and carried a recurrent HMGA2-NCOR2 gene fusion. " 01/01/2021 - "SMARCB1-deficient soft tissue neoplasms comprise a variety of tumors with epithelioid morphology and frequent expression of keratin and/or EMA. " 02/01/1993 - "An immunohistochemical panel that includes antibodies to both cytokeratin and B72.3, in addition to other lineage-selective mesenchymal markers, is useful in the diagnostic recognition of epithelioid soft tissue neoplasms." 10/01/1996 - "Epithelioid sarcoma is a peculiar soft-tissue neoplasm of uncertain origin, which is characterized by an epithelioid morphology of tumor cells coexpressing epithelial (keratin) and nonepithelial (vimentin) antigens. "

Therapies and Procedures

1.	Radiofrequency Ablation 08/17/2021 - "Background and Objective: To evaluate the effectiveness of radiofrequency ablation (RFA) using the moving-shot technique for benign soft tissue neoplasm. " 08/17/2021 - "Ultrasound-Guided Moving Shot Radiofrequency Ablation of Benign Soft Tissue Neoplasm." 09/01/2004 - "The purpose of this study was to analyze the feasibility, safety, and efficacy of radiofrequency ablation (RFA) to treat pain from soft tissue neoplasms. "
2.	Therapeutics 02/01/2016 - "As the classification of soft tissue neoplasms continues to diversify, so does the approach to therapy. " 01/07/2014 - "In tumours not approachable by surgery or reduction of immunosuppression, the angiogenic microenvironment might be a potential target of therapy, an approach that is well utilised in other soft tissue neoplasms. " 02/01/2011 - "Non-thermal irreversible electroporation (N-TIRE) has shown promise as an ablative therapy for a variety of soft-tissue neoplasms. " 04/01/2004 - "The high technical and clinical success together with a low complication rate makes RFA of osseous and soft tissue neoplasms a valuable supportive tool for patients not referable for surgery or systemic therapy." 09/15/1991 - "In addition, the role for endocrine therapy in other soft tissue neoplasms should be determined."
3.	Drug Therapy (Chemotherapy) 03/01/2012 - "[III. The role of chemotherapy for soft tissue neoplasm]." 01/01/2011 - "Systemic chemotherapy induced the remarkable improvement of the lesions, the infiltrative lung shadow and the soft tissue neoplasm. " 01/01/1969 - "[Locoregional chemotherapy in the treatment of soft tissue neoplasms]." 01/01/2003 - "Chemotherapy regimens are available for soft tissue neoplasms and osteosarcoma and are primarily designed to improve local control. " 01/01/2023 - "There was a higher number of moderate adverse reactions (grade 2 according to the Common Terminology Criteria for Adverse Events Version 4.0) between the first and third chemotherapy cycles, with a latency period of between 6 and 15 min., generally lasting less than 30 min. Association with the degree of immediate adverse reaction (grade) has been observed in male subjects over 71 years of age, with soft tissue neoplasm type and monoclonal antibodies therapeutic group."
4.	Myocutaneous Flap 12/01/2004 - "Benign soft tissue neoplasm of a myocutaneous flap masquerading as recurrent squamous cell carcinoma of parotid gland."
5.	Intravenous Administration 01/01/1994 - "The technique was combined with intravenous administration of gadolinium-DTPA in five patients with lumbosacral spine conditions, four patients with soft tissue neoplasms and three with skeletal neoplasms; all patients were examined at 0.5 T. "