Skatole (3 Methylindole)

08/01/1987 - "Additionally, administration of deutero-3-methylindole caused less pulmonary edema compared to 3-methylindole, as assessed by increased wet lung weights. "
10/01/1984 - "3-Methylindole (3MI) is the causative agent in the development of acute bovine pulmonary edema. "
04/01/1983 - "3-Methylindole (3MI) was orally administered as a single dose of 0.1-0.2 gm/kgm which then produced acute pulmonary edema in cattle. "
02/01/1982 - "3-Methylindole (3MI) can cause acute pulmonary edema in goats. "
02/01/1982 - "Concentration of 3-methylindole (3MI) and distribution of radioactivity from 14C-3MI in goat tissues associated with acute pulmonary edema."

03/01/1984 - "Intravenous administration of 3-methylindole produced lung injury more rapidly and at a lower dose rate than the oral route. "
05/01/1996 - "This study was designed to investigate whether 3-methylindole (3-Mi), a tryptamine analogue, could cause pulmonary injury in calves other than by cytotoxicity. "
01/31/1983 - "A study was conducted to investigate the relationship between glutathione (GSH) status, in-vivo metabolite covalent binding and 3-methylindole (3MI)-induced lung injury in goats. "

08/01/2009 - "Skatole causes pulmonary edema and emphysema in ruminants and causes damage to lung Clara cells in animals and humans. "
04/01/1984 - "The 3-methylindole is also the cause of naturally-occurring acute bovine pulmonary edema and emphysema after abrupt pasture change. "
10/01/1979 - "3-Methylindole and naturally occurring acute bovine pulmonary edema and emphysema."
06/01/1976 - "Induction of pulmonary edema and emphysema in goats by intraruminal administration of 3-methylindole."
04/08/1975 - "3-Methylindole has been shown in previous work to cause pulmonary edema and emphysema in cattle and goats. "

07/01/1988 - "After pretreatments the other four goats in each group were challenged with 3-methylindole (0.03 g/kg body weight) by intrajugular infusion. "
04/01/1985 - "Sixteen Holstein cattle allotted into 4 groups (4 cattle/group) were each given a single oral dosage of 0.2 g of 3-methylindole (3MI)/kg of body weight. "
08/01/1984 - "Six adult goats were given 0.2 g of 3-methylindole (3MI)/kg of body weight orally. "
06/01/1980 - "Transmission electron microscopy was used to characterize early pulmonary lesions in goats after a 2-hour intravenous infusion of 0.04 g 3-methylindole (3MI) per kilogram body weight. "
04/01/1982 - "In unanesthetized ponies, arterial blood gas tensions, pulmonary mechanics, and lung volumes were determined before and 24 to 48 hours after oral administration of 500 ml of corn oil or 100 mg of 3-methylindole (3MI)/kg of body weight in 500 ml of corn oil. "

01/01/1985 - "The object of this study was to explore the use of fecal skatole and indole and breath methane and hydrogen as metabolic markers of the anaerobic colonic flora in patients with unresected large bowel cancer or polyps. "
01/01/1985 - "Fecal skatole and indole and breath methane and hydrogen in patients with large bowel polyps or cancer."