|1.||Agarwal, Rajesh: 16 articles (02/2013 - 03/2002)|
|2.||Oberlies, Nicholas H: 15 articles (08/2015 - 05/2005)|
|3.||Polyak, Stephen J: 13 articles (08/2015 - 05/2007)|
|4.||Gharagozloo, Marjan: 9 articles (08/2014 - 08/2006)|
|5.||Katiyar, Santosh K: 8 articles (11/2015 - 12/2002)|
|6.||Singh, Rana P: 8 articles (12/2008 - 03/2002)|
|7.||Hawke, Roy L: 7 articles (05/2013 - 09/2008)|
|8.||Graf, Tyler N: 7 articles (02/2013 - 05/2005)|
|9.||Schuppan, D: 7 articles (04/2007 - 06/2000)|
|10.||Agarwal, R: 7 articles (02/2006 - 04/2000)|
11/13/2003 - "Silymarin, a defined mixture of natural flavonoid, has recently been shown to have potent cancer chemopreventive efficacy against colon carcinogenesis in rat model; however, the mechanism of such efficacy is not elucidated. "
03/01/2002 - "This study reports in vivo therapeutic efficacy of silymarin against skin tumors with mechanistic rationale. "
07/01/2008 - "Silymarin is a known cancer chemopreventive agent, but the relative anticancer efficacy of its constituents is still unknown. "
11/01/2006 - "Studies are now in progress to demonstrate the clinical efficacy of silymarin against various cancers."
11/01/2007 - "In recent years, increasing body of evidence has underscored the cancer preventive efficacy of silymarin in both in vitro and in vivo animal models of various epithelial cancers. "
04/01/2007 - "The results suggest that silymarin may be beneficial in the treatment of UVA-induced skin oxidative injury and inflammation. "
04/01/2015 - "In this study, we investigated the effects of silymarin, a polyphenolic flavonoid isolated from the seeds and fruits of milk thistle, on CS-induced airway inflammation and oxidative stress in mice and the possible mechanisms. "
08/28/2015 - "Natural products like silymarin may be useful as tools to define how metabolic, stress, and repair pathways regulate cellular inflammation. "
08/28/2015 - "Silymarin, a characterized extract of the seeds of milk thistle (Silybum marianum), suppresses cellular inflammation. "
08/28/2015 - "Silymarin Suppresses Cellular Inflammation By Inducing Reparative Stress Signaling."
11/01/2013 - "Silymarin, a C25 containing flavonoid from the plant Silybum marianum, has been the gold standard drug to treat liver disorders associated with alcohol consumption, acute and chronic viral hepatitis, and toxin-induced hepatic failures since its discovery in 1960. "
05/01/2009 - "In this study, our purpose was to determine whether silymarin improves symptoms, signs and laboratory test results in patients with acute clinical hepatitis, regardless of etiology. "
03/01/2001 - "Research results of some small studies suggest silymarin has hepatoprotective, antiinflammatory, and regenerative properties producing a beneficial effect for some types of hepatitis. "
01/01/2012 - "[Pharmacological effects of Abies polyprenols and carsil on alcohol-induced hepatitis]."
05/01/2009 - "Although silymarin is hepatoprotective in animal experiments and some human hepatotoxic exposures, its efficacy in ameliorating the symptoms of acute clinical hepatitis remains inconclusive. "
07/01/2002 - "Silymarin has so far failed to clearly show an antifibrotic effect in human studies, whereas animal experiments suggest that this mixture of flavolignanes may be beneficial in patients which have not yet developed cirrhosis. "
01/01/2012 - "This study investigates the anti-inflammatory/anti-fibrotic effects of silymarin and/or PZQ on schistosomal hepatic fibrosis. "
07/01/2008 - "In this study, we investigated the restoration of the CCl4-induced hepatic fibrosis by high dose of silymarin in rats. "
10/01/2003 - "There were corresponding morphologic changes: at 36 months, 2 of 6 animals fed alcohol had cirrhosis and 2 septal fibrosis, with perivenular fibrosis in 2, whereas with alcohol + silymarin, there was only 1 cirrhosis and 1 septal fibrosis, with perivenular fibrosis in 2, and virtually no lesions in the remaining 2. Silymarin retards the development of alcohol-induced hepatic fibrosis in baboons, consistent with several positive clinical trials. "
02/01/2001 - "Clinical studies with silymarin: fibrosis progression is the end point."
|5.||Liver Cirrhosis (Hepatic Cirrhosis)
04/01/1998 - "Silymarin has protective effects in different experimental conditions, but its efficacy in human liver cirrhosis has not been completely established. "
01/01/1989 - "The efficacy of silymarin treatment in preventing biochemical and histological alterations in CCL4-induced liver cirrhosis in rats was studied. "
03/01/2015 - "Our study aims to investigate the effects of two different doses of Silymarin on a CCl4-induced model of liver fibrosis with a focus on the early stages of liver injury. "
01/01/2012 - "According to open studies the long-term administration of silymarin significantly increased survival time of patients with alcohol induced liver cirrhosis. "
12/21/2008 - "According to open studies, the long administration of silymarin significantly increased the survival time of patients with alcohol-induced liver cirrhosis. "
|4.||Glycyrrhizic Acid (Glycyrrhizin)
|10.||Glutathione (Reduced Glutathione)
|1.||Drug Therapy (Chemotherapy)