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Sickle Cell Trait

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The condition of being heterozygous for hemoglobin S.

Also Known As:

Cell Trait, Sickle; Cell Traits, Sickle; Sickle Cell Traits; Trait, Sickle Cell; Traits, Sickle Cell

Networked: 348 relevant articles (9 outcomes, 31 trials/studies) for this Disease, Comments

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Disease Context: Research Results

Hemic and Lymphatic Diseases
- Hematologic Diseases: 1467
  - Anemia: 15930
    - Hemolytic Anemia: 3237
      - Congenital Hemolytic Anemia: 198
        Sickle Cell Anemia: 3795
        Sickle Cell Trait: 348
  - Hemoglobinopathies: 868
    - Sickle Cell Anemia: 3795
      - Sickle Cell Trait: 348
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 449
- Inborn Genetic Diseases: 568
  - Hemoglobinopathies: 868
    - Sickle Cell Anemia: 3795
      - Sickle Cell Trait: 348
  - Congenital Hemolytic Anemia: 198
    - Sickle Cell Anemia: 3795
      - Sickle Cell Trait: 348

Related Diseases

1.	Malaria
2.	Sickle Cell Anemia (Hemoglobin S Disease)
3.	Infection
4.	Falciparum Malaria (Plasmodium falciparum Malaria)
5.	beta-Thalassemia (Cooley's Anemia)

Experts

1.	Connes, Philippe: 9 articles (12/2008 - 07/2005)
2.	Hue, Olivier: 7 articles (12/2008 - 03/2003)
3.	Tripette, Julien: 6 articles (12/2008 - 01/2007)
4.	Deloron, Philippe: 6 articles (03/2007 - 10/2002)
5.	Hardy-Dessources, Marie-Dominique: 5 articles (01/2008 - 03/2003)
6.	Etienne-Julan, Maryse: 5 articles (01/2008 - 03/2003)
7.	Wouassi, Dieudonné: 4 articles (02/2010 - 07/2005)
8.	Thiriet, Patrice: 4 articles (02/2010 - 07/2005)
9.	Martin, Cyril: 4 articles (02/2010 - 07/2005)
10.	Sara, Fagnété: 4 articles (11/2007 - 03/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sickle Cell Trait:

1.	IronIBA 11/01/2002 - "51% of sickle cell trait and 86% of control cases had mild to severe anaemia which improved with iron therapy in trait cases. " 04/01/2008 - "Twenty two sickle cell anaemia (SS), 47 sickle cell trait (AS) and 150 normal control (AA) individuals who were iron deficient, were given iron therapy for a period of 12 wk and the laboratory investigations were repeated at the 13th wk. RESULTS: Sixty seven per cent of subjects with sickle cell anaemia and 26 per cent with sickle cell trait had elevated ZPP/H ratios (>80 micromol/mol) as against 22.8 per cent of normal individuals. " 10/01/1982 - "The reduced frequency of iron deficiency anaemia in sickle cell trait may be explained by increased iron absorption, or alternatively by reduced iron requirements and a lower risk of discrepancy between iron supply and demand. " 10/01/1982 - "The prevalence of iron deficiency anaemia defined as the coexistence of Hb below 13 g/dl in adult males and below 12 in adult females and children with two laboratory indicators of iron deficiency, was 10.3% in the normal population as against 1.3% in the sickle cell trait group (P less than 0.008). " 10/01/1982 - "There was a reciprocal relation between the presence of sickle cell trait and of iron deficiency anaemia. " Order ALL the reference details at left...
2.	Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)IBA 10/01/1981 - "Sickle cell trait and glucose-6-phosphate dehydrogenase deficiency. " 04/01/1981 - "Sickle cell trait, thalassaemia and glucose-6-phosphate dehydrogenase deficiency in the Bhil tribe of southern Rajasthan." 01/01/1980 - "The prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency and sickle cell trait was determined in 371 Cameroonian males and 668 male blood donors in Chicago. " 01/01/1980 - "Interaction of sickle cell trait and glucose-6-phosphate dehydrogenase deficiency in Cameroon." 05/03/1979 - "The overall frequency of sickle-cell trait was 7.8 per cent and of glucose-6-phosphate dehydrogenase dificiency 11.2 per cent. " Order ALL the reference details at left...
3.	Sickle HemoglobinIBA 07/01/2003 - "Among children with sickle cell trait, percentage of hemoglobin S was significantly greater in children who had tortuosity than percentage of hemoglobin S in children who had normal blood vessels at MR angiography (P <.03). " 12/01/2005 - "RESULTS: Of 1,906 children screened preoperatively, 79 (4.1%) were diagnosed as having sickle cell trait and three (0.16%) as having some form of SCD: one had homozygous hemoglobin S and two had sickle-hemoglobin C disease. " 02/01/1984 - "However, for purposes of the regulation, sickle cell trait is defined as 41% or less S hemoglobin. " 02/01/1984 - "Hemoglobin S levels in sickle cell trait individuals." 01/01/1977 - "In those with sickle cell trait, the proportion of sickle hemoglobin in hemolysates (mean = 26%, range 19-32%) was substantially lower than that reported for any other population." Order ALL the reference details at left...
4.	CytokinesIBA 06/01/2003 - "Protection against severe clinical manifestations of Plasmodium falciparum malaria among sickle cell trait subjects is due to modification of the release of cytokines and/or cytoadherence of infected erythrocytes to the host vascular beds." Order ALL the reference details at left...
5.	Proteins (Proteins, Gene)IBA 10/01/1982 - "Because of the central role of iron in the function of a great number of enzymes and proteins, it is possible that protection against iron deficiency anaemia by the sickle cell trait may result in improved working capacity and a lower incidence of infections." Order ALL the reference details at left...
6.	Immunologic Factors (Immunomodulators)IBA 05/01/1989 - "The same longitudinal techniques were used to examine the effect of two non-immunological factors, sickle cell trait and mosquito net usage, both of which showed significant protection against clinical episodes and malaria." Order ALL the reference details at left...
7.	EnzymesIBA 10/01/1982 - "Because of the central role of iron in the function of a great number of enzymes and proteins, it is possible that protection against iron deficiency anaemia by the sickle cell trait may result in improved working capacity and a lower incidence of infections." Order ALL the reference details at left...
8.	sulfadoxine-pyrimethamine (Fansidar)FDA Link 12/01/2002 - "Increased efficacy of sulfadoxine-pyrimethamine in the treatment of uncomplicated falciparum malaria among children with sickle cell trait in Western Kenya." Order ALL the reference details at left...
9.	Hemoglobins (Hemoglobin)IBA 12/05/2008 - "This study compared the nocturnal autonomic nervous system (ANS) activity in seven sickle cell trait (SCT) carriers and six subjects with normal hemoglobin in response to exercise Sympathetic and parasympathetic indices of nocturnal ANS were measured in the two groups before and 24 and 48 h after a strenuous exercise consisting of the repetition of three maximal exercise bouts. " 01/01/2008 - "This study investigated the cardioventilatory responses during heavy exercise in sickle cell trait carriers (SCTc) and subjects with normal hemoglobin (control group). " 11/01/2007 - "This study investigated 1) whether ventilatory and lactic thresholds (VT and LT, respectively) are different in sickle cell trait carriers (SCTc) and subjects with normal hemoglobin (control group), and 2) whether the first LT and VT and the second LT and VT are respectively coincident in the two populations. " 12/01/2002 - "OBJECTIVE: The aim of the study is to assess the pregnancy outcome among Omani women with sickle cell trait (SCT), and to compare it with a control group of Omani women with normal hemoglobin. " 08/01/2009 - "Hemoglobin electrophoresis revealed an 41.8% HbS diagnostic of sickle cell trait. " Order ALL the reference details at left...
10.	hemoglobin ASIBA 08/01/1997 - "STUDY DESIGN AND METHODS: RBCs from 12 donors with sickle cell trait (Hb AS) and from 12 with normal Hb (Hb AA) were studied. " 02/01/2008 - "We conclude that the H/H131 genotype and H131 allele rather than Hb AS genotype (sickle cell trait patients) appear to associate with the Fulani ethnic group." 11/01/2007 - "Sickle cell trait (hemoglobin AS) is the most common genotype and has traditionally been considered a benign condition. " 09/01/2004 - "BACKGROUND Red blood cell (RBC) components from donors with sickle cell trait (Hb AS) often occlude white blood cell (WBC) reduction filters. " 07/01/2003 - "PURPOSE: To determine whether sickle cell trait (hemoglobin AS) is associated with abnormalities in the brain of asymptomatic children. " Order ALL the reference details at left...

Therapies and Procedures

1.	Chemoprevention 06/25/2003 - "However, the sickle cell trait, fever and the use of chemoprophylaxis did not have a significant association with the presence of P. " 03/01/2007 - "BACKGROUND & OBJECTIVES: Sickle-cell trait confers protection against malaria while homozygote sickle-cell disease (SCD) patients are at greater risk of malaria infection, hence the use of malaria chemoprophylaxis in SCD patients. " Order ALL the reference details at left...
2.	Mosquito Nets 05/01/1989 - "The same longitudinal techniques were used to examine the effect of two non-immunological factors, sickle cell trait and mosquito net usage, both of which showed significant protection against clinical episodes and malaria." Order ALL the reference details at left...
3.	Transplantation (Transplant Recipients) 01/01/1985 - "The child's sickle cell anemia was converted to the donor's sickle cell trait and she remains in complete remission from her leukemia 22 months following transplantation. " Order ALL the reference details at left...
4.	Cardiopulmonary Bypass (Heart-Lung Bypass) 10/01/2004 - "Con: Exchange transfusion is not required for sickle cell trait patients undergoing cardiopulmonary bypass." 10/01/2004 - "Pro: Exchange transfusion is required for sickle cell trait patients undergoing cardiopulmonary bypass." 10/01/1996 - "[Cardiac surgery using cardiopulmonary bypass in a patient with sickle-cell trait]" 11/01/1984 - "Hypothermic cardiopulmonary bypass in a patient with sickle-cell trait." 02/01/2006 - "Data of 43 patients with sickle cell traits and 2 with sickle cell disease, who were operated on under cardiopulmonary bypass and cold cardioplegic arrest in a tertiary center from the beginning of 1995 to the end of 2004, were retrospectively analyzed. " Order ALL the reference details at left...
5.	Transplants (Transplant) 12/01/2007 - "We report a case of living-related renal transplant, in which both the recipient and the donor had sickle cell trait, and the postoperative course for both was uneventful." 12/01/2007 - "Kidney transplant from sickle cell trait donor to sickle cell trait recipient." 09/01/1999 - "IMPLICATIONS: Fast-track cardiac anesthesia can be used safely in patients with sickle cell trait undergoing first-time coronary artery bypass graft surgery. " 09/01/1999 - "We conducted a retrospective review of 10 patients with sickle cell trait (SCT) and 30 patients (cohort control) without SCT undergoing first-time coronary artery bypass graft surgery with cardiopulmonary bypass. " 03/01/1978 - "A black male with known sickle cell trait (hemoglobin AS) received two cadaveric renal transplants in succession. " Order ALL the reference details at left...

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