Sialoglycoproteins

Glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities.

Also Known As:

Networked: 332 relevant articles (3 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kato, Yukinari: 15 articles (10/2021 - 12/2003)
2.	Kaneko, Mika Kato: 9 articles (02/2015 - 11/2006)
3.	Wang, Jingfeng: 6 articles (11/2021 - 02/2016)
4.	Keay, Susan K: 6 articles (01/2012 - 08/2004)
5.	Mishima, Kazuhiko: 6 articles (10/2010 - 06/2006)
6.	Xue, Changhu: 5 articles (11/2021 - 02/2016)
7.	Mandal, Chitra: 5 articles (01/2012 - 10/2004)
8.	Kaneko, Mika K: 4 articles (10/2021 - 06/2006)
9.	Fujita, Naoya: 4 articles (01/2016 - 12/2003)
10.	Ogasawara, Satoshi: 4 articles (06/2015 - 01/2008)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2007 - "The aim of this study was comparative analysis of cytoplasmic and nuclear sialoglycoproteins isolated from thyroid benign and malignant tumors as well as non-neoplastic lesions. " 10/15/1995 - "In addition to the authors' previous findings, the results of these studies support the concept that cancer is a problem of development and differentiation, and, to the authors' knowledge, prove definitively for the first time that synthesis and expression of hCG, its subunits, and its fragments, is a common biochemical denominator of cancer, providing the scientific basis for studies of its prevention and/or control by active and/or passive immunization against these sialoglycoproteins." 01/01/1978 - "It is suggested that such studies should be extended to postoperative patients and that circulating sialoglycoprotein assays could be one of the ways of monitoring tumor growth, including growth during the nonvisible phase." 12/01/1973 - "Electron microscopic studies on sialoglycoprotein layer of rat Friend tumor cells." 06/01/2022 - "Tumors feature elevated sialoglycoprotein content. "
2.	Osteoporosis 10/31/2023 - "The present study's results demonstrated that T-ES, a novel sialoglycopeptide, showed significant anti-osteoporosis effects, which will accelerate the utilization of T-ES as an alternative marine drug or functional food for anti-osteoporosis." 02/01/2016 - "In this study, we investigated the improvement of osteoporosis by sialoglycoproteins isolated from the eggs of Carassius auratus (Ca-SGP) in ovariectomized rats. " 10/31/2023 - "Several sialoglycopeptides were isolated from several fish eggs and exerted anti-osteoporosis effects. " 10/31/2023 - "Structural Characterization and Anti-Osteoporosis Effects of a Novel Sialoglycopeptide from Tuna Eggs." 10/01/2018 - "The effect of sialoglycoprotein isolated from Gadous morhua eggs (Gm-SGP) on ovariectomized (OVX) induced osteoporosis, which is characterized by high bone turnover activity was investigated. "
3.	Proteinuria 01/01/2006 - "In conclusion, revealed in our study diminished immunoexpression of podocalyxin and significant correlation with the level of proteinuria in FSGS patients suggests a possible role of this sialoprotein in the alteration of the glomerular filtration barrier in this disease." 07/01/2008 - "Disruption of glomerular sialoproteins, however, causes proteinuria and indicates a critical role for these cell-associated glycoproteins in glomerular filtration. " 09/01/1996 - "In PAN, defective sialylation of a major sialoprotein of podocytes, podocalyxin, has been demonstrated and the consequent decrease of anionic charge suggested as a causative factor for increased glomerular permeability and proteinuria. " 03/01/1978 - "The absence of GBM deposits closely correlated with reduced staining for polyanionic glomerular sialoprotein in proteinuric kidneys, since PA-perfused kidneys studied 2 wk after resolution of proteinuria demonstrated return of normal staining for sialoprotein and development of subepithelial complex deposits similar to those in contralateral control kidneys. " 01/01/2004 - "Furthermore, sulfate components such as heparan sulfate proteoglycan might be involved initially followed by carboxyl components such as sialoglycoproteins in the glomeruli of patients with IgA nephropathy contributing to the occurrence of proteinuria. "
4.	Lung Neoplasms (Lung Cancer) 01/01/2021 - "Thus, study on lung cancer associated sialoglycoproteins is of paramount relevance to have a deeper insight into the mechanism of the disease pathogenesis. " 01/01/1989 - "Significance of serum sialoglycoproteins in patients with lung cancer." 12/07/2021 - "In a model study using lung cancer cells, early elution by a high percentage of acetonitrile prominently prefilters nonglycopeptides, facilitating high enrichment specificity for glycopeptides (92-96%) and sialoglycopeptides (77-89%) in the subsequent hydrophilic fractions. "
5.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 05/01/1995 - "Recent immunocytochemical and morphometric studies with an organelle-specific antiserum against MG-160, an intrinsic membrane sialoglycoprotein of the Golgi apparatus, have shown in several patients with sporadic amyotrophic lateral sclerosis (ALS), and in a few patients with related conditions, a fragmentation of the Golgi apparatus of spinal cord motor neurons which resembles the dispersion of the organelle observed in cells treated with microtubule depolymerizing agents. " 03/15/2000 - "The Golgi apparatus (GA) of the anterior horn cells in the spinal cord was examined by immunohistological methods with an antibody against the MG-160 protein, a conserved intrinsic membrane sialoglycoprotein of the medial cisternae of the GA, in three patients with familial amyotrophic lateral sclerosis (FALS) with posterior column involvement. " 10/01/1994 - "In this paper we review studies from our laboratory dealing with 1) the Golgi apparatus during mitosis and the role of microtubules in maintaining the structure of the organelle, 2) the endocytosis of antibodies, exogenous lectins, and toxins into the Golgi apparatus of several cells including neurons in vivo and in vitro, 3) the traffic of MG-160, a membrane sialoglycoprotein of the medial cisternae of the Golgi apparatus, from the trans-Golgi network to the Golgi cisternae, and 4) the involvement of the Golgi apparatus of motor neurons in the pathogenesis of amyotrophic lateral sclerosis. "

Related Drugs and Biologics

1.	Glycophorins (Glycophorin C)
2.	Biomarkers (Surrogate Marker)
3.	Catenins
4.	Lectins
5.	Proteins (Proteins, Gene)
6.	Enzymes
7.	N-Acetylneuraminic Acid (Sialic Acid)
8.	Sialyltransferases
9.	podocalyxin
10.	Osteopontin

Related Therapies and Procedures

1.	Tooth Movement Techniques
2.	Ovariectomy (Oophorectomy)
3.	Ligation
4.	Therapeutics
5.	Immunotherapy