Sialadenitis

INFLAMMATION of salivary tissue (SALIVARY GLANDS), usually due to INFECTION or injuries.

Also Known As:

Adenitis, Salivary Gland; Chronic Sialadenitis; Irradiation-Induced Sialadenitis; Salivary Gland Inflammation; Sialoadenitis; Adenitides, Salivary Gland; Chronic Sialadenitides; Inflammation, Salivary Gland; Inflammations, Salivary Gland; Irradiation Induced Sialadenitis; Irradiation-Induced Sialadenitides; Salivary Gland Adenitides; Salivary Gland Adenitis; Salivary Gland Inflammations; Sialadenitides; Sialadenitides, Chronic; Sialadenitides, Irradiation-Induced; Sialadenitis, Chronic; Sialadenitis, Irradiation-Induced; Sialitides; Sialoadenitides; Sialitis

Networked: 799 relevant articles (42 outcomes, 71 trials/studies)

Relationship Network

Disease Context: Research Results

Stomatognathic Diseases: 705
- Mouth Diseases: 98
  - Salivary Gland Diseases: 102
    - Sialadenitis: 799

Related Diseases

1.	Salivary Gland Calculi (Sialolithiasis)
2.	Autoimmune Pancreatitis
3.	Dacryocystitis (Dacryoadenitis)
4.	Immunoglobulin G4-Related Disease
5.	Neoplasms (Cancer)

Experts

1.	Li, Wei: 11 articles (01/2022 - 01/2015)
2.	Sumida, Takayuki: 10 articles (09/2020 - 07/2010)
3.	Tsuboi, Hiroto: 10 articles (09/2020 - 07/2010)
4.	Matsumoto, Isao: 9 articles (09/2020 - 07/2010)
5.	Maehara, Takashi: 8 articles (01/2022 - 12/2012)
6.	Moriyama, Masafumi: 8 articles (01/2022 - 12/2012)
7.	Nakamura, Seiji: 8 articles (01/2022 - 12/2012)
8.	Takahashi, Hiroki: 8 articles (09/2019 - 01/2012)
9.	Yamamoto, Motohisa: 8 articles (09/2019 - 01/2012)
10.	Iizuka, Mana: 8 articles (05/2015 - 07/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sialadenitis:

1.	Adrenal Cortex Hormones (Corticosteroids)IBA 06/15/1993 - "Corticosteroids were immediately effective in eliminating signs of periorbital disease and sialadenitis. " 03/01/2022 - "Efficacy of corticosteroid ductal irrigation in acute salivary gland inflammation induced in a rat model." 07/01/2022 - "This qualitative systematic review evaluates the evidence in support of the use of oral corticosteroids in patients undergoing sialendoscopy for the treatment of obstructive sialadenitis. " 06/15/1993 - "A 3-month corticosteroid treatment was used because the sialadenitis and periorbital disease were immune-mediated. " 04/01/2012 - "Corticosteroids are effective for the treatment of chronic sclerosing sialadenitis, but the natural clinical course of this disease is not fully understood. "
2.	AutoantibodiesIBA 07/01/2010 - "This finding suggests that some autoantibodies encoded by germline or less mutated VH genes may fail to be eliminated and could play a role in the development of SS and IgG4-related sclerosing sialadenitis." 03/01/2016 - "Results from this study suggest blockade of CXCL13 and BAFFR together may be an effective therapeutic strategy in preventing salivary hypofunction and reducing autoantibody titers and sialadenitis in patients with SS. " 01/01/2023 - "Although blood examination revealed all autoantibodies to be negative, a lip biopsy revealed lymphocytic sialadenitis, and a sialoscintigraphy indicated hypofunctional salivary glands, leading to the diagnosis of seronegative SS. " 01/01/2019 - "Additionally, therapeutic treatment with MR1 suppressed CD40 pathway genes and sialadenitis, inhibited ectopic lymphoid structure formation and autoantibody production, as well as decreased the frequency of antibody-secreting cells in SGs but had minimal effects on AQP5 expression in NOD/ShiLtJ SGs. " 01/01/2019 - "Additionally, we dosed MR1 (anti-CD154 antibody) in NOD mice after the onset of SS-like disease and examined the effects of MR1 treatment on sialadenitis, autoantibody production, SG leucocyte infiltration, gene expression downstream of CD40 and acquaporin 5 (AQP5) expression. "
3.	SteroidsIBA 01/01/2018 - "This pilot study confirms that interventional sialendoscopy with steroid duct irrigation significantly reduces the number of painful episodes of sialadenitis and improves the subjective sensation of oral dryness and other disease symptoms in patients with SS. " 01/01/2018 - "To evaluate the effectiveness of interventional sialendoscopy alone or combined with outpatient intraductal steroid irrigations in patients with sialadenitis due to Sjögren's syndrome (SS). " 12/01/2014 - "After steroid treatment, the prominent sonographic feature of IgG4-related sialadenitis gradually receded. " 12/01/2014 - "The changes on ultrasonography in 14 patients with IgG4-related sialadenitis before and after steroid treatment were evaluated. " 05/01/2012 - "In this article, we report a 46-year-old male patient who was admitted with recurrent sialadenitis attacks which responded well to steroid treatment for three years, but recur after the cessation of the therapy. "
4.	Immunoglobulin G (IgG)IBA 08/01/2016 - "The incidence of IgG4 related sialadenitis in the present study is 2%, indicating that it is a rare condition. " 08/15/2020 - "Serological IgG4 level was significantly elevated and the diagnosis of IgG4 sclerosing sialadenitis was confirmed by histopathology. " 12/18/2019 - "The serum IgG4 level of the patients in the IgG4-related sialadenitis group was increased, with an average (9.60±6.43) g/L. " 08/28/2019 - "The authors have chosen to report this case because of the unusual presentation of IgG4 disease as acute sialadenitis." 08/28/2019 - "Kuttner's tumour, also known as chronic sclerosing sialadenitis, is a localised form of IgG4 disease which presents as asymptomatic submandibular gland swelling. "
5.	IodineIBA 01/01/2021 - "This study explores the unique characters of high dose radioactive iodine (RAI) induced chronic sialadenitis. " 01/01/2016 - "The purpose of this study was to determine whether sialendoscopy could ameliorate radioactive iodine-induced obstructive sialadenitis and restore the salivary gland dysfunction in recalcitrant radioactive iodine sialadenitis. " 01/01/2023 - "Chronic sialadenitis is the most common complication of radioactive iodine (RAI) treatment. " 01/01/2023 - "Iodine contrast-induced sialadenitis (CIS) is an uncommon adverse effect to iodine-containing contrast exposition. " 01/01/2023 - "Management of iodine contrast induced salivary gland swelling (sialadenitis): experiences from an observational study."
6.	AntibodiesIBA 10/01/2002 - "Our results suggested that anti-SDF-1 antibodies injection was effective in inhibiting diabetes and insulitis without affecting autoimmune sialoadenitis or SS in NOD mice. " 01/01/1982 - "The purpose of the present study was to investigate the possibility of experimental induction of sialadenitis in rats by heterologous anti-salivary gland antibodies. " 10/01/2022 - "Non-specific chronic sialadenitis (NSCS) is a common pathology of labial salivary glands (LSGs), and NSCS with positive anti-SSA/SSB antibodies is common in clinical practice. " 01/01/2019 - "Moreover, anti-RNP-positive patients had higher median gammaglobulin levels (22.5 vs 13 g/L, p<0.01), more frequently anti-SSA antibodies (90.5% vs 67.1%, p=0.03), but less frequent lymphocytic sialadenitis with a focus score ≥1 (66.7% vs 85.5%, p=0.03). " 01/01/2016 - "Serum levels of anti-CarP antibodies were measured in Norwegian patients with pSS (n=78) and corresponding controls (n=74) using ELISA and analysed in relation with exocrine gland function, degree of salivary gland inflammation, signs of ectopic germinal centre (GC) formation and immunological markers. "
7.	IodidesIBA 01/01/2010 - "The risk for sialadenitis is directly related to serum iodide levels (> 10 mg/100 mL) and inversely related to normal renal function so that in renal impairment, ICM can be eliminated through alternative pathways such as the salivary glands and other excretory organs." 01/01/1965 - "[Studies on iodide-induced sialadenitis and I-131-activity of the salivary glands]." 08/20/2021 - "Acute iodide sialadenitis is a rare adverse reaction to iodinated contrast that causes self-limited salivary gland swell-ing. " 05/01/2021 - "A rare cause of non-infectious sialadenitis: Iodide-induced sialadenitis associated with coronary angiography." 01/01/2021 - "A rare cause of non-infectious sialadenitis: Iodide-induced sialadenitis associated with coronary angiography."
8.	DNA (Deoxyribonucleic Acid)IBA 09/01/2002 - "Absence of human parvovirus B19 DNA in myoepithelial sialadenitis of primary Sjögren's syndrome." 12/01/1999 - "The genomic DNA of the backcross mice was examined by simple sequence-length polymorphism analysis, and the highly associated polymorphic microsatellite markers with sialadenitis were determined as sialadenitis susceptibility loci. " 04/01/2023 - "Since DNA is the main intracellular target of radiation, and the integrity of the DNA structure is critical to genomic stability and the cellular survival of salivary glands, regulating radiation-induced DNA damage offers great promise in preventing and managing radiation sialadenitis. " 02/01/2016 - "Gene expression was analyzed by DNA microarray in submandibular glands (SMGs) from patients with IgG4-RD (n = 5), chronic sialoadenitis (CS) (n = 3), and controls (n = 3). " 02/01/2016 - "The demonstration of CMV-DNA would significantly clarify the cause of death and collection of epidemiological data in SUDI cases with clinical history and histopathological findings of CMV infection accompanying chronic CMV sialadenitis. "
9.	Anti-Bacterial Agents (Antibiotics)IBA 04/01/1982 - "This affords possible explanation for such phenomena as the therapeutic value that often accrues from sialography and the efficacy of many different antibiotics in obstructive sialadenitis, despite the fact that most antibiotics do not normally permeate to the saliva." 01/01/2019 - "There was no difference in sialadenitis between the dietary groups treated with antibiotics; the mice were protected by microbiota depletion regardless of diet. " 01/01/2018 - "Median duration between sialadenitis onset and death, concomitant treatment, average infusion volume per day, site of onset, symptoms, effectiveness of antibiotic treatment, and mean duration until symptomatic relief. " 01/01/2014 - "If the predefined inclusion criteria were met, the articles were screened for various variables: antibiotic type, mode of administration, type of examined saliva, peak salivary antibiotic concentrations, biochemical methodology, and minimal inhibitory concentrations of bacteria implicated in sialadenitis (Staphylococcus aureus, Viridans streptococci, various gram-negative strains, and anaerobes). " 01/01/2014 - "Therefore, an evidence-based literature review was conducted to identify antibiotics with favorable pharmacokinetics in saliva and to establish recommendations for the antibiotic treatment of sialadenitis. "
10.	AntigensIBA 01/01/2007 - "Immunization of Balb/c mice with modified auto-antigens for induction of autoimmune sialoadenitis." 05/01/2001 - "In contrast, these antigens were not found in the minor salivary glands of normal subjects or of patients with mild sialoadenitis. " 03/15/1998 - "Clonal salivary gland infiltrates associated with myoepithelial sialadenitis (Sjögren's syndrome) begin as nonmalignant antigen-selected expansions." 02/01/2006 - "However, the thymocytes that were generated in the absence of CCR7 or CCR7L were potent in causing autoimmune dacryoadenitis and sialadenitis in mice and were thus incapable of establishing central tolerance to organ-specific antigens. " 01/01/1992 - "The cell-mediated immune response to this antigen was studied by the leukocyte migration inhibition test (LMT) in patients with chronic pancreatitis (CP), Sjögren's syndrome (SjS), and chronic sialoadenitis (CSA). "

Therapies and Procedures

1.	Therapeutics 01/01/2022 - "Intraductal administration of gentamicin + NAC + betamethasone seemed effective for the therapy of chronic obstructive sialoadenitis. " 12/01/2013 - "Salivary endoscopy is a minimally invasive technique that is effective in the management of idiopathic chronic sialadenitis refractory to medical therapy. " 02/04/2022 - "Clinical application of the novel questionnaire produced by this study will allow for a patient-centered assessment of the patient reported effectiveness of sialendoscopy assisted therapies for management of chronic sialadenitis. " 09/01/2007 - "To review the results of surgical management of chronic parotid sialadenitis refractory to medical therapy, with particular respect to long-term symptom resolution and development of post-operative complications. " 12/01/2021 - "This study aimed to evaluate the long-term outcome and quality of life of IgG4-related sialadenitis (IgG4-RS) patients after submandibular gland (SMG) excision without immunomediate therapy. "
2.	Neck Dissection (Radical Neck Dissection) 04/01/2020 - "The indications were chronic sialoadenitis (67.7%), pleomorphic adenoma (12.9%) and as a part of neck dissection for oncologic clearance of neck (19.4%). " 04/01/2020 - "Chronic submandibular sialoadenitis, benign submandibular gland tumours and cases of neck dissection where level I cervical lymph nodes were not involved by metastasis were included in this study. " 06/01/1998 - "Removal of the submandibular gland is most commonly performed for sialolithiasis, chronic sialoadenitis, or as part of a neck dissection. " 10/01/1997 - "The likelihood of temporary facial weakness correlated with the extent of surgery and was especially influenced by tumor location deep to the plane of the facial nerve, previous parotid surgery, a diagnosis of sialadenitis, and the addition of neck dissection to the parotidectomy. " 10/01/1997 - "Based on the diagnosis and extent of surgery, rates of facial weakness were 16.5% and 13%, respectively, for benign and malignant tumors located in the superficial lobe and treated with limited superficial parotidectomy; 30% and 34% for sialadenitis treated with complete superficial parotidectomy and near-total parotidectomy, respectively; 31% and 100%, respectively, for benign and malignant lobe tumors treated with near-total parotidectomy; 83% for parotidectomy associated with a neck dissection; and 33% for patients who had previous parotid surgery. "
3.	Conservative Treatment 01/01/2021 - "Compared to patients electing for conservative management, patients with sialadenitis without sialolithasis treated with SASDS had improved symptom scores and a greater reduction of symptom severity after 6 months. " 12/01/2016 - "Historically, for patients with chronic sialadenitis who failed conservative management, salivary gland removal was the standard treatment option. " 01/01/2014 - "[New in conservative therapy of chronic sialoadenitis]." 02/15/2010 - "Acute and chronic sialadenitis not responding to conservative treatment requires an appropriate surgical approach. " 01/01/2006 - "Acute and chronic sialadenitis not responding to conservative treatment requires an appropriate surgical approach."
4.	Radiotherapy 04/01/2023 - "Radiation sialadenitis is the most common complication associated with radiotherapy applied to the head and neck and it severely affects patients' quality of life. " 01/15/2021 - "However, radiotherapy results in inevitable side effects, particularly radiation sialadenitis, that significantly impairs quality of life. " 02/01/2019 - "Radiotherapy combined with sialadenitis significantly raised ORN incidence in HNC patients except for NPC patients. " 10/01/2021 - "Based on our and other's studies, NAMPT may have dual roles in cancer radiotherapy: the upregulation of NAMPT could serve to suppress radiotherapy complications such as radiation sialadenitis, and combination regimens that involve NAMPT inhibitors may enhance efficacy of radiotherapy for cancer treatment." 10/01/2021 - "Salivary gland dysfunction is associated with different diseases, including Sjögren syndrome, sialadenitis, and iatrogenic disease, due to radiotherapy and medications and is usually reported as a loss of secretory volume, which can range in severity. "
5.	Drug Therapy (Chemotherapy) 01/01/2021 - "Acute Sialadenitis in Children With Acute Leukemia During Chemotherapy: A Case Series Study." 01/01/2021 - "We submitted 4 patients with acute leukemia who got diagnosed with acute sialadenitis during their chemotherapy period." 02/01/2014 - "The modern technology of sialoendoscopy to treat obstructive sialoadenitis from mucous plugging, and the addition of rituximab to current chemotherapy, have allowed patients with Sjögren's syndrome to have a better quality of life and, if they develop lymphomatous changes, a significant increase in their disease remission and survival rate. "