Shy-Drager Syndrome

A progressive neurodegenerative condition of the central and autonomic nervous systems characterized by atrophy of the preganglionic lateral horn neurons of the thoracic spinal cord. This disease is generally considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Affected individuals present in the fifth or sixth decade with ORTHOSTASIS and bladder dysfunction; and later develop FECAL INCONTINENCE; anhidrosis; ATAXIA; IMPOTENCE; and alterations of tone suggestive of basal ganglia dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p536)
Also Known As:
Dysautonomia-Orthostatic Hypotension Syndrome; Syndrome, Dysautonomia-Orthostatic Hypotension; Autonomic Failures, Progressive; Dysautonomia Orthostatic Hypotension Syndrome; Dysautonomia-Orthostatic Hypotension Syndromes; Dysautonomic Orthostatic Hypotension; Dysautonomic Orthostatic Hypotensions; Failure, Progressive Autonomic; Failures, Progressive Autonomic; Hypotension Syndrome, Dysautonomia-Orthostatic; Hypotension Syndromes, Dysautonomia-Orthostatic; Hypotension, Dysautonomic Orthostatic; Hypotensions, Dysautonomic Orthostatic; Idiopathic Orthostatic Hypotension, Shy Drager Type; Orthostatic Hypotensions, Dysautonomic; Progressive Autonomic Failure; Progressive Autonomic Failures; Shy Drager Syndrome; Syndrome, Dysautonomia Orthostatic Hypotension; Syndrome, Shy-Drager; Syndromes, Dysautonomia-Orthostatic Hypotension; Autonomic Failure, Progressive; Idiopathic Orthostatic Hypotension, Shy-Drager Type; Orthostatic Hypotension, Dysautonomic
Networked: 142 relevant articles (3 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Orthostatic Hypotension (Postural Hypotension)
2. Multiple System Atrophy
3. Parkinson Disease (Parkinson's Disease)
4. Pure Autonomic Failure
5. Hypertension (High Blood Pressure)


1. Wenning, Gregor K: 3 articles (01/2013 - 08/2010)
2. Goldstein, David S: 2 articles (06/2004 - 07/2002)
3. Jordan, Jens: 2 articles (07/2002 - 03/2002)
4. Biaggioni, Italo: 2 articles (05/2002 - 03/2002)
5. Osorio-Espinoza, Angélica: 1 article (09/2013)
6. Arias-Montaño, José-Antonio: 1 article (09/2013)
7. Arias, Juan-Manuel: 1 article (09/2013)
8. Flores-Clemente, Cecilia: 1 article (09/2013)
9. Leurs, Rob: 1 article (09/2013)
10. Escamilla-Sánchez, Juan: 1 article (09/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Shy-Drager Syndrome:
1. Idiopathic orthostatic hypotensionIBA
2. Propranolol (Inderal)FDA LinkGeneric
3. Midodrine (Midon)FDA LinkGeneric
4. Trimethaphan (Trimetaphan)IBA
5. Norepinephrine (Noradrenaline)FDA LinkGeneric
6. Dopamine (Intropin)FDA LinkGeneric
8. Dopamine Agonists (Dopamine Agonist)IBA
9. XenonIBA
10. GABA-A Receptors (GABA(A) Receptor)IBA

Therapies and Procedures

1. Intravenous Infusions
2. Denervation
3. General Anesthesia
4. Anesthesia
5. Sympathectomy (Sympathectomies)