|1.||Orthostatic Hypotension (Postural Hypotension)
|2.||Multiple System Atrophy
|3.||Parkinson Disease (Parkinson's Disease)
|4.||Pure Autonomic Failure
|5.||Hypertension (High Blood Pressure)
|1.||Wenning, Gregor K: 3 articles (01/2013 - 08/2010)|
|2.||Goldstein, David S: 2 articles (06/2004 - 07/2002)|
|3.||Jordan, Jens: 2 articles (07/2002 - 03/2002)|
|4.||Biaggioni, Italo: 2 articles (05/2002 - 03/2002)|
|5.||Osorio-Espinoza, Angélica: 1 article (09/2013)|
|6.||Arias-Montaño, José-Antonio: 1 article (09/2013)|
|7.||Arias, Juan-Manuel: 1 article (09/2013)|
|8.||Flores-Clemente, Cecilia: 1 article (09/2013)|
|9.||Leurs, Rob: 1 article (09/2013)|
|10.||Escamilla-Sánchez, Juan: 1 article (09/2013)|
|1.||Idiopathic orthostatic hypotensionIBA
01/01/1980 - "[Idiopathic orthostatic hypotension and the Shy-Drager syndrome: hemodynamic and pharmacological studies in seven patients (author's transl)]."
01/01/1983 - "[Shy-Drager syndrome and idiopathic orthostatic hypotension]."
01/01/1982 - "Hypothalamic dysfunction in a case of idiopathic orthostatic hypotension (shy-Drager Syndrome)."
10/13/1981 - "A case of idiopathic orthostatic hypotension (Shy-Drager syndrome) in a 50-year-old man is reported. "
10/13/1981 - "[Idiopathic orthostatic hypotension (Shy-Drager syndrome). "
|2.||Propranolol (Inderal)FDA LinkGeneric
11/01/1981 - "Effective treatment of orthostatic hypotension by propranolol in the Shy-Drager syndrome."
05/01/1982 - "Indomethacin and propranolol combined treatment for Shy-Drager syndrome."
01/01/1986 - "[Shy-Drager syndrome: description of a clinical case which failed to respond to propranolol, ergotamine and indomethacin]."
|3.||Midodrine (Midon)FDA LinkGeneric
06/01/1993 - "Therefore, a recent multicenter study evaluated the safety and efficacy of midodrine therapy in 97 patients with neurogenic orthostatic hypotension due to various etiologies: Shy Drager syndrome (No. 18); Bradbury Eggleston syndrome (idiopathic orthostatic hypotension) (No. 20); diabetic autonomic neuropathy (No. 27); Parkinson's disease (No. 22); and miscellaneous (No. 10). "
07/01/1981 - "Five patients with idiopathic orthostatic hypotension, two of whom had central nervous system manifestations (Shy-Drager syndrome), were treated with midodrine, an investigational alpha-adrenergic agonist, in a dosage of 2.5 to 5 mg three times daily. "
11/01/1992 - "In order to increase CO and VR, we orally administered both denopamine 10 mg (a selective beta 1-adrenergic agonist) and midodrine HCl 4 mg (a selective alpha 1-adrenergic agonist) to six patients with progressive autonomic failure (AF). "
|5.||Norepinephrine (Noradrenaline)FDA LinkGeneric
01/01/1998 - "We conclude that ambulatory noradrenaline infusion is a new valuable tool for long-term treatment of advanced Shy-Drager syndrome."
01/01/1998 - "Ambulatory infusion of noradrenaline for long-term treatment of Shy-Drager syndrome."
03/01/1995 - "The Schellong test revealed deficient sympathetic orthostatic pressure response without an increase of plasma norepinephrine; therefore, a Shy-Drager syndrome was diagnosed. "
02/01/1995 - "At this point, after an extensive survey of the literature, the diagnosis of Shy-Drager syndrome was proposed and proved by monitoring ECG and serum levels of noradrenaline during postural changes. "
04/16/1985 - "[Ambulatory noradrenaline infusion in refractory Shy-Drager syndrome]."
|6.||Dopamine (Intropin)FDA LinkGeneric
05/01/1993 - "We report the case of an elderly woman with severe dysautonomic orthostatic hypotension in whom a deficit in dopamine B hydroxylase has been established. "
05/01/1993 - "Dopamine B hydroxylase deficiency responsible for severe dysautonomic orthostatic hypotension in an elderly patient."
04/01/1976 - "Subsensitivity to dopamine was observed in patients with Parkinson's disease, but supersensitivity in those with the Shy-Drager syndrome."
10/02/1989 - "In both patients with Shy-Drager syndrome, basal plasma concentrations of epinephrine and dopamine were low under resting conditions and could not be stimulated in the upright position. "
04/01/1976 - "Blood pressure responses to noradrenaline and dopamine infusions in Parkinson's disease and the Shy-Drager syndrome."
02/01/1978 - "Autopsy confirmed the Shy-Drager syndrome and multiple areas of degeneration were observed in areas of the CNS outside the medullary respiratory centers, suggesting their importance in the origin of the respiratory abnormalities in SAS."
02/01/1978 - "A patient with autonomic insufficiency and extrapyramidal signs (Shy-Drager syndrome) and sleep apnea syndrome (SAS) underwent hemodynamic studies. "
03/01/2004 - "Although SAS is frequently associated with Shy-Drager syndrome but not with PAF, patients with PAF had been reported to have degenerative changes in the central nervous system overlapping with Shy-Drager syndrome or Lewy body disease. "
|8.||Dopamine Agonists (Dopamine Agonist)IBA
|10.||GABA-A Receptors (GABA(A) Receptor)IBA
08/01/1995 - "We used positron emission tomography with [11C]flumazenil to study gamma-aminobutyric acid type A/benzodiazepine receptor binding quantitatively in the cerebral hemispheres, basal ganglia, thalamus, cerebellum, and brainstem of 72 subjects, including 14 with multiple system atrophy of the ataxic (olivopontocerebellar atrophy) type, 5 with multiple system atrophy of the extrapyramidal/autonomic (Shy-Drager syndrome) type, 18 with sporadic olivopontocerebellar atrophy, 15 with dominantly inherited olivopontocerebellar atrophy, and 20 normal control subjects with similar age and sex distributions. "
03/01/1985 - "The arginine vasopressin response to an intravenous infusion of hypertonic saline was determined in six patients with progressive autonomic failure. "
08/01/1986 - "The blood pressure (BP) and heart rate (HR) responses to 5 min incremental intravenous infusions of noradrenaline (NA) and arginine vasopressin (AVP) were investigated both in patients with progressive autonomic failure (PAF) and in normal volunteers. "
04/01/1976 - "Studies of pulse rate and blood pressure responses to graded intravenous infusions of noradrenaline and dopamine were performed on five patients with Parkinson's disease, five with the Shy-Drager syndrome and seven healthy subject. "
09/01/1988 - "In patients with progressive autonomic failure and multiple system atrophy, the bladder neck was incompetent in every case and the striated muscle of the urethra was affected by a process of denervation and re-innervation. "
04/01/1987 - "These findings do not permit the vocal cord paralysis seen in the Shy-Drager syndrome to be explained by motorneuron loss and denervation. "
01/01/1981 - "1. Denervation supersensitivity to adrenergic agonists occurs after degeneration of the sympathetic nervous system in the disease called multiple system atrophy (MSA) or the Shy Drager Syndrome.2. Supersensitivity to the chronotropic effect of i.v. isoprenaline on the heart was demonstrated in eight subjects with sympathetic nervous system degeneration and MSA.3. There was an increased number of beta-receptors present in MSA as measured by [H(3)]dihydroalprenolol ([H(3)]DHA) binding to beta-receptors on lymphocytes isolated from venous blood taken from the MSA subjects compared with [H(3)]DHA binding to lymphocytes from seven normal subjects. "
01/01/2001 - "A 53-year-old man with Shy-Drager syndrome underwent emergency surgery for the resection of the larynx under general anesthesia. "
06/01/1989 - "A 57-year-old man with Shy-Drager syndrome underwent plastic surgery for decubitus on the buttocks under general anesthesia. "
07/01/2005 - "A 61-year-old man with Shy-Drager Syndrome underwent partial pulmonary lobectomy under general anesthesia combined with thoracic epidural anesthesia. "
07/01/2005 - "[A patient with Shy-Drager syndrome managed under general anesthesia with thoracic epidural anesthesia]."
01/01/1997 - "Sympathetic denervation of myocardium demonstrated by 123I-MIBG scintigraphy in pure progressive autonomic failure."
10/01/1995 - "2. Eighteen subjects with chronic sympathetic denervation were studied; 12 had pure autonomic failure and six had additional neurological features of the Shy-Drager syndrome. "