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Sertoli Cell Tumor

Gonadal neoplasm composed entirely of SERTOLI CELLS or may have a component of GRANULOSA CELLS. Some of the Sertoli cell tumors produce ESTROGEN or ANDROGENS, but seldom in sufficient quantity to cause clinical symptoms such as FEMINIZATION or masculinization (VIRILISM).
Also Known As:
Tumor, Sertoli Cell
Networked: 77 relevant articles (0 outcomes, 4 trials/studies)

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Granulosa Cell Tumor
3. Sex Cord-Gonadal Stromal Tumors (Sex Cord-Stromal Tumor)
4. Sertoli-Leydig Cell Tumor
5. Carcinoma (Carcinomatosis)

Experts

1. Barner, Ross: 3 articles (03/2009 - 09/2007)
2. Vang, Russell: 3 articles (03/2009 - 09/2007)
3. Zhao, Chengquan: 3 articles (03/2009 - 09/2007)
4. Young, Robert H: 3 articles (11/2008 - 02/2005)
5. Shen, Keng: 2 articles (02/2022 - 06/2008)
6. Baydar, Dilek Ertoy: 2 articles (01/2019 - 08/2017)
7. McCluggage, W Glenn: 2 articles (01/2019 - 07/2007)
8. Dabbs, David: 2 articles (03/2009 - 10/2008)
9. McManus, Kim: 2 articles (03/2009 - 10/2008)
10. Vinh, Tuyethoa N: 2 articles (03/2009 - 10/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sertoli Cell Tumor:
1. Inhibins (Inhibin)IBA
2. Aromatase (CYP19)IBA
3. beta CateninIBA
4. SteroidsIBA
11/01/2012 - "Male precocious puberty may be caused by a sex steroid-producing Leydig or Sertoli cell tumor of the testis. "
02/01/1995 - "Testicular steroid biosynthesis in a boy with a large cell calcifying Sertoli cell tumor producing prepubertal gynecomastia."
07/01/2007 - "Neoplasms studied were adult granulosa cell tumor (n = 40), juvenile granulosa cell tumor (n = 8), Sertoli cell tumor (n = 1), Sertoli-Leydig cell tumor (n = 14), Leydig cell tumor (n = 2), steroid cell tumor, not otherwise specified (n = 2), sclerosing stromal tumor (n = 1), sex cord tumor with annular tubules (n = 2), and fibroma (n = 15). "
02/01/2022 - "Results Among the 18 cases,7(7/18,38.9%)developed secondary sex signs before puberty,including 5 cases showing precocity(including 2 cases of juvenile granulosa cell tumor,1 case of gonadoblastoma,1 case of ovarian follicular cyst,and 1 case of 46,XY simple gonadal dysplasia combined with dysgerminoma)and 2 cases presenting masculine manifestations(1 case of steroid cell tumor and 1 case of sclerosing stromal tumor).The rest 11(11/18,61.1%)cases showed abnormal development of secondary sexual characteristics during puberty,including 8 cases with masculine manifestations or abnormal menstruation after menarche(7 cases with sex cord stromal cell tumor and 1 case with cystic granulosa cell tumor),2 cases with primary amenorrhea(1 case with androgen insensitivity syndrome combined with testicular sertoli cell tumor and 1 case with endometriosis cyst combined with reproductive tract malformation),and 1 case diagnosed as 46,XX gonadal dysplasia with serous cystadenoma and no secondary sexual development during puberty. "
05/01/2007 - "The interstitial cell tumor, but not the Sertoli cell tumor, was immunohistochemically positive for Melan-A, consistent with steroid production. "
5. MART-1 AntigenIBA
6. Calbindin 2IBA
09/01/2007 - "The diagnostic utility of WT1 in Sertoli cell tumor is similar to inhibin but better than that of calretinin."
09/01/2007 - "Coordinate patterns for the extent of expression of WT1, inhibin, and calretinin in pure Sertoli cell tumor showed that all 3 markers were positive in 54% of cases; however, 42% were positive for WT1 and inhibin but negative for calretinin. "
09/01/2007 - "Additionally, inhibin and calretinin immunostaining were performed in all cases of Sertoli cell tumor for purposes of comparing expression with WT1. "
03/01/2009 - "Immunohistochemical stains for markers which have known variable specificity for sex cord-stromal lineage [inhibin, calretinin, MART-1/melan-A, CD99, steroidogenic factor 1 (SF-1, adrenal 4-binding protein), and WT1], were performed in 127 cases of 5 different types of ovarian sex cord-stromal tumors: adult granulosa cell tumor (n=32), Sertoli cell tumor (n=27), Sertoli-Leydig cell tumor (n=18), steroid cell tumor (n=25), and fibroma/fibrothecoma (n=25). "
02/15/2012 - "The tumor was positive for cytokeratin AE1/AE3, CAM 5.2, vimentin, CD56, CK8, synaptophysin and S100, and negative for inhibin, calretinin, WT1, CD99, CD117, CK5/6, CK7, chromogranin A, placental alkaline phosphatase, neuron specific enolase, D2-40, smooth muscle actin, Melan-A, epithelial membrane antigen and carbonic anhydrase IX. This is the second reported case of a Sertoli cell tumor with reactivity limited to neuroendocrine markers and the first such case of the sclerosing variant. "
7. Testosterone (Sustanon)FDA Link
8. LipidsIBA
9. Estrogens (Estrogen)FDA Link
10. Growth Hormone (Somatotropin)IBA

Therapies and Procedures

1. Orchiectomy (Orchidectomy)
2. Metastasectomy
3. Therapeutics
4. Lymph Node Excision (Lymph Node Dissection)
5. Ligation