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Glycine Hydroxymethyltransferase (Serine Hydroxymethyltransferase)

A pyridoxal phosphate enzyme that catalyzes the reaction of glycine and 5,10-methylene-tetrahydrofolate to form serine. It also catalyzes the reaction of glycine with acetaldehyde to form L-threonine. EC 2.1.2.1.
Also Known As:
Serine Hydroxymethyltransferase; Threonine Aldolase; Allothreonine Aldolase; Aldolase, Allothreonine; Aldolase, Serine; Aldolase, Threonine; Hydroxymethylase, Serine; Hydroxymethyltransferase, Glycine; Hydroxymethyltransferase, Serine; Transhydroxymethylase, Serine; Serine Aldolase; Serine Hydroxymethylase; Serine Transhydroxymethylase; 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
Networked: 137 relevant articles (2 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Paiardini, Alessandro: 5 articles (11/2020 - 05/2013)
2. Contestabile, Roberto: 5 articles (01/2018 - 01/2007)
3. Giardina, Giorgio: 4 articles (01/2021 - 01/2016)
4. Paone, Alessio: 4 articles (01/2021 - 01/2016)
5. Rinaldo, Serena: 4 articles (01/2021 - 01/2016)
6. Cutruzzolà, Francesca: 4 articles (11/2020 - 01/2016)
7. Naushad, Shaik Mohammad: 4 articles (09/2019 - 10/2012)
8. Stover, Patrick J: 4 articles (05/2018 - 08/2005)
9. Guiducci, Giulia: 3 articles (01/2021 - 11/2016)
10. Rabinowitz, Joshua D: 3 articles (01/2021 - 12/2014)

Related Diseases

1. Parkinson Disease (Parkinson's Disease)
2. Breast Neoplasms (Breast Cancer)
3. Neoplasms (Cancer)
4. Hypoxia (Hypoxemia)
01/01/2020 - "Hypoxia-induced expression of phosphoglycerate dehydrogenase (PHGDH) and the mitochondrial serine hydroxymethyltransferase (SHMT2) was observed in three of five tested glioma cell lines. "
12/01/2014 - "In this study, we demonstrate that the serine catabolic enzyme, mitochondrial serine hydroxymethyltransferase (SHMT2), is induced when MYC-transformed cells are subjected to hypoxia. "
12/05/2014 - "Contributions of the serine-isocitrate lyase pathway, glycine cleavage system, and c1-THF/serine hydroxymethyltransferase pathway in the acclimation to dark anoxia were found. "
01/01/2022 - "Endothelium-specific DKK1-knockout (DKK1ECKO) mice significantly ameliorated hypoxia+Sugen5416 and hypoxia-induced PH. More importantly, neutralizing anti-DKK1 antibody treatment significantly attenuated established hypoxia+Sugen5416 PH. Results of proteome analysis of control and DKK1-knockdown human pulmonary artery endothelial cells identified a significantly differentially expressed protein, SHMT2 (serine hydroxymethyltransferase 2), a key metabolic enzyme in one-carbon metabolism, as a novel DKK1 target. "
01/01/2023 - "The present study is aimed to investigate the impact of hypoxia on the expression of PHGDH (phosphoglycerate dehydrogenase), PSAT1 (phosphoserine aminotransferase 1), PSPH (phosphoserine phosphatase), ATF4 (activating transcription factor 4), and SHMT1 (serine hydroxymethyltransferase 1) in U87MG glioblastoma cells in relation to knockdown of ERN1 with the intent to reveal the role of ERN1 signaling pathway on the endoplasmic reticulum stress-dependent regulation of expression of these genes. "
5. Glioblastoma (Glioblastoma Multiforme)

Related Drugs and Biologics

1. Methionine (L-Methionine)
2. Transferases
3. S-Adenosylmethionine (Ademetionine)
4. Antidepressive Agents (Antidepressants)
5. Adenosine (Adenocard)
6. Enzymes
7. Serine (L-Serine)
8. Carbon
9. Thymidylate Synthase
10. Phosphoglycerate Dehydrogenase (Dehydrogenase, Phosphoglycerate)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Therapeutics
3. Palliative Care (Palliative Therapy)