|1.||Stover, Patrick J: 3 articles (04/2014 - 08/2005)|
|2.||Naushad, Shaik Mohammad: 3 articles (01/2014 - 10/2012)|
|3.||Kutala, Vijay Kumar: 2 articles (11/2013 - 10/2012)|
|4.||Contestabile, Roberto: 2 articles (05/2013 - 01/2007)|
|5.||Selhub, Jacob: 2 articles (04/2013 - 08/2005)|
|6.||Yuthavong, Yongyuth: 2 articles (01/2012 - 06/2008)|
|7.||Leartsakulpanich, Ubolsree: 2 articles (01/2012 - 06/2008)|
|8.||Hitre, Erika: 2 articles (01/2012 - 01/2010)|
|9.||Kralovánszky, Judit: 2 articles (01/2012 - 01/2010)|
|10.||Kongkasuriyachai, Darin: 2 articles (01/2012 - 06/2008)|
|1.||Parkinson Disease (Parkinson's Disease)
07/01/2000 - "The recombinant low-specificity D-threonine aldolase was shown to be an efficient biocatalyst for resolution of L-beta-3,4-methylenedioxyphenylserine, an intermediate for production of a therapeutic drug for Parkinson's disease."
05/01/1984 - "This paper reviews and correlates three separate recent findings that implicate the one-carbon cycle in neuropsychiatric disease: (i) the demonstration by kinetic studies that the Vmax of methionine adenosine transferase (MAT) is reduced in some schizophrenics and depressives and is increased in some manics, and that the activity of serine hydroxymethyltransferase (SHMT) is reduced in a further subpopulation of schizophrenics; (ii) the demonstration that S-adenosylmethionine (the product of MAT) is an effective clinical antidepressant; and (iii) the reports that L-methionine is an effective treatment for certain of the symptoms of Parkinson's disease. "
01/01/2007 - "PLP-dependent enzymes for which there are already commercially available drugs are DOPA decarboxylase (involved in the Parkinson disease), GABA aminotransferase (epilepsy), serine hydroxymethyltransferase (tumors and malaria), ornithine decarboxylase (African sleeping sickness and, potentially, tumors), alanine racemase (antibacterial agents), and human cytosolic branched-chain aminotransferase (pathological states associated to the GABA/glutamate equilibrium concentrations). "
|2.||Breast Neoplasms (Breast Cancer)
10/01/2012 - "Cytosolic serine hydroxymethyltransferase (cSHMT) conferred protection against basal-like breast cancer (OR: 0.47, 95% CI: 0.22-0.98). "
01/01/2015 - "Positive correlation between expression level of mitochondrial serine hydroxymethyltransferase and breast cancer grade."
08/01/2014 - "Polymorphism of cytosolic serine hydroxymethyltransferase and breast cancer risk: evidence from a meta-analysis."
09/01/2008 - "Polymorphism of cytosolic serine hydroxymethyltransferase, estrogen and breast cancer risk among Chinese women in Taiwan."
01/01/2010 - "Cytoplasmic serine hydroxymethyltransferase (cSHMT) affects the flow of one-carbon units through the folate metabolic network, but there is little research on a role for genetic variation in cSHMT in determining breast cancer risk. "
01/01/2014 - "A series of studies have explored the role of cytosolic serine hydroxymethyltransferase (SHMT1) C1420T polymorphism in cancer risk, but their results were conflicting rather than conclusive. "
01/01/2015 - "Published data regarding the association between the cytosolic serine hydroxymethyltransferase (SHMT1) C1420T (Leu474Phe) polymorphism and solid tumor risk have shown inconclusive results. "
07/01/2014 - "Association between cytosolic serine hydroxymethyltransferase (SHMT1) gene polymorphism and cancer risk: a meta-analysis."
01/01/2014 - "C1420T polymorphism of cytosolic serine hydroxymethyltransferase and risk of cancer: a meta-analysis."
05/01/2013 - "In fact, silencing of mitochondrial serine hydroxymethyltransferase was shown to halt cancer cell proliferation. "
04/01/1980 - "Thymidylate synthetase and serine transhydroxymethylase activities in preleukemic disorders of erythropoiesis and acute leukemia."
01/01/2014 - "The current study was aimed to elucidate the association of thymidylate synthase (TYMS) 5'- UTR 28bp tandem repeat and cytosolic serine hydroxymethyltransferase (cSHMT) C1420T polymorphisms with acute leukemia in South Indian subjects. "
01/01/1989 - "In order to determine the biochemical basis for the cytotoxicity of homofolates, poly-gamma-glutamyl derivatives of homofolate (HPteGlu) and tetrahydrohomofolate (H4HPteGlu) were synthesized and tested as inhibitors of glycinamide ribonucleotide formyltransferase (GARFT), aminoimidazolecarboxamide ribonucleotide formyltransferase (AICARFT), thymidylate synthase, and serine hydroxymethyltransferase (SHMT) in extracts of Manca human lymphoma and L1210 murine leukemia cells. "
12/01/2014 - "In this study, we demonstrate that the serine catabolic enzyme, mitochondrial serine hydroxymethyltransferase (SHMT2), is induced when MYC-transformed cells are subjected to hypoxia. "
12/05/2014 - "Contributions of the serine-isocitrate lyase pathway, glycine cleavage system, and c1-THF/serine hydroxymethyltransferase pathway in the acclimation to dark anoxia were found. "
|7.||5' Untranslated Regions (5' UTR)
|8.||Folic Acid (Vitamin M)
|10.||Glycine (Aminoacetic Acid)
|1.||Drug Therapy (Chemotherapy)