|1.||Hashimoto, Kenji: 17 articles (06/2015 - 06/2003)|
|2.||Pollegioni, Loredano: 15 articles (09/2015 - 03/2008)|
|3.||Cravatt, Benjamin F: 15 articles (07/2015 - 08/2002)|
|4.||Chung, Jing-Gung: 13 articles (09/2015 - 03/2010)|
|5.||Sacchi, Silvia: 12 articles (09/2015 - 04/2006)|
|6.||Javitt, Daniel C: 12 articles (05/2015 - 07/2002)|
|7.||de Koning, T J: 10 articles (12/2015 - 12/2000)|
|8.||Iyo, Masaomi: 10 articles (06/2015 - 06/2003)|
|9.||Heresco-Levy, Uriel: 10 articles (03/2015 - 02/2004)|
|10.||Molla, Gianluca: 9 articles (09/2015 - 04/2006)|
|1.||Schizophrenia (Dementia Praecox)
12/15/2011 - "D-Serine administration has been shown to be effective for the treatment of schizophrenia symptoms. "
02/01/2013 - "This study evaluated the feasibility, safety, tolerability, and efficacy of 12 weeks of D-serine, combined with CRT in the treatment of cognitive deficits in schizophrenia at two academic sites in parallel, in India and the United States. "
02/01/2013 - "Feasibility, safety, and efficacy of the combination of D-serine and computerized cognitive retraining in schizophrenia: an international collaborative pilot study."
05/01/2012 - "D-serine (DSR) allosterically modulates in-vivo NMDAR-mediated neurotransmission and has been shown to improve negative and antipsychotic drug-induced parkinsonian symptoms in schizophrenia patients. "
06/01/2015 - "This study suggests that SB induced antipsychotic effects in the PCP model of schizophrenia, although it did not increase D-serine levels in the brain."
12/02/2015 - "In the current study, we have addressed the conserved phosphorylation site serine 192 in human MCAK to characterize its function in more depth in human cancer cells. "
01/01/2015 - "However, dependence on increased PHGDH expression extends beyond production of serine alone, and further studies of PHGDH function are necessary to elucidate its role in cancer cells. "
03/01/2008 - "Further studies lead to the isolation and characterization of phosphatidyl serine (PS) as a NO inhibitory factor produced by mammary tumor cells. "
08/01/2005 - "Immunohistochemical studies revealed much higher phosphorylation of FADD at serine 194 in normal epithelial cells than in cancer cells, although FADD was found to be highly expressed to the same extent in both cases. "
09/01/2004 - "The goal of the present study was to identify specific populations of cells that contain activated Akt-1, as determined by the presence ofphosphorylated Akt at serine 473 (p Akt), during development of skin tumors using a murine multi-stage carcinogenesis model. "
10/01/2004 - "The present study suggests that increased SAPK/JNK activation may play an important role in the pathogenesis of vascular insulin resistance via inhibitory serine phosphorylation of IRS-1."
11/21/2015 - "Hepatitis C virus NS5A promotes insulin resistance through IRS-1 serine phosphorylation and increased gluconeogenesis."
02/01/2015 - "Mean exosomal levels of extracted P-serine 312-IRS-1 and P-pan-tyrosine-IRS-1 by ELISA and the ratio of P-serine 312-IRS-1 to P-pan-tyrosine-IRS-1 (insulin resistance factor, R) for AD and DM2 and P-serine 312-IRS-1 and R for FTD were significantly different from those for case control subjects. "
02/01/2015 - "Finally, high-fat diet (HFD)-induced insulin resistance was associated with enhanced phosphorylation of PKCθ, IKK, JNK, and IRS1 at serine 307 in white adipose tissues from WT mice, all of which were not found in Mpo knockout mice fed HFDs. "
09/01/2012 - "pJNK, pIKK-β and pIRS-1 levels were increased in OG with pJNK and pIKK-β levels positively correlated with serine pIRS-1 and negatively with GLUT4 supporting their role in insulin resistance. "
01/01/2016 - "l-Serine treatment led in patient 1 to a significant reduction of seizures after one week of treatment and decrease of electroencephalographic abnormalities within one year. "
09/01/2000 - "Treatment with oral L-serine abolished seizures and improved psychomotor development, hyperexcitability, head growth, cortical and subcortical hypotrophy, and hypomyelination of the brain on MRI scans. "
10/21/1999 - "In contrast, L-Serine-O-phosphate gives only partial protection against sound-induced clonic seizures for 15-30 min (ED(50) 79 [45-139] nmol) in DBA/2 mice. "
07/01/2012 - "Serine synthesis defects, characterized by developmental delay and seizures, have been described in children. "
02/01/2011 - "Both patients responded favourably to relatively low dosages of serine supplementation with cessation of seizures, normalisation of their EEG abnormalities and improvement of well-being and behaviour. "
11/01/2001 - "Protective immunity studies revealed that P-8c1 (serine metalloproteinase-glycolipid complex) confers comparable protection against infection as immunopurified P-8. "
01/01/2013 - "In this study, we show that the N-terminal region of GR is required for RSV repression of GR transactivation and that RSV infection of lung epithelial cells reduces ligand-dependent GR phosphorylation at serine 211 and serine 226. "
03/01/2006 - "In the present study, we showed that a serine residue of Akt was phosphorylated in Vero E6 cells in subconfluent culture and that Akt was dephosphorylated rapidly after SARS-CoV infection without up-regulation of its phosphorylation. "
06/01/1998 - "In this study, we examined gB oligomerization, processing, and incorporation into mature virus during infection by two mutant viruses in which either the gB Cys-633 [KgB(C633S)] or both Cys-633 and Cys-596 [KgB(C596S/C633S)] residues were mutated to serine. "
11/01/2015 - "Although effective inhibitor combinations are in development for the treatment of infections caused by Gram-negative bacteria with serine carbapenemases, better options are still necessary for pathogens that produce metallo-β-lactamases (MBLs). "
|1.||Glycine (Aminoacetic Acid)
|5.||Protein Kinases (Protein Kinase)
|8.||Glutamic Acid (Glutamate)
|10.||Aspartic Acid (Aspartate)
|2.||Drug Therapy (Chemotherapy)
|3.||Heterologous Transplantation (Xenotransplantation)