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Semicarbazones

A class of organic compounds that are derivatives of imines formed by condensation reactions between KETONES or ALDEHYDES and SEMICARBAZIDES.

Also Known As:

Semicarbazone

Networked: 67 relevant articles (2 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Semicarbazides: 7
  - Semicarbazones: 67

Experts

1.	Gambino, Dinorah: 5 articles (12/2018 - 02/2005)
2.	Cerecetto, Hugo: 3 articles (06/2015 - 02/2005)
3.	González, Mercedes: 3 articles (06/2015 - 02/2005)
4.	Khanam, Jahan Ara: 3 articles (02/2013 - 06/2012)
5.	Sriram, Dharmarajan: 3 articles (05/2007 - 08/2004)
6.	Yogeeswari, Perumal: 3 articles (05/2007 - 08/2004)
7.	Liu, Yajing: 2 articles (01/2021 - 01/2020)
8.	Scalese, Gonzalo: 2 articles (12/2018 - 06/2015)
9.	Kalinowski, Danuta S: 2 articles (05/2018 - 01/2015)
10.	Richardson, Des R: 2 articles (05/2018 - 01/2015)

Related Diseases

1.	Neuralgia (Stump Neuralgia) 01/01/2022 - "Lastly, the lead compound exhibited promising ex-vivo FAAH/MAGL inhibition activity at the dose of 10 mg/kg and 20 mg/kg. Thus, these findings suggest that the semicarbazone-based lead compound can be a potential template for the development of agents for neuropathic pain." 08/12/2004 - "In the search for more efficacious drugs to treat neuropathic pain states, a series of phenoxyphenyl pyridines was designed based on 4-(4-flurophenoxy)benzaldehyde semicarbazone. " 05/17/2007 - "The present study aims at the design and synthesis of newer gamma-aminobutyric acid (GABA) derivatives with the combination of aryl semicarbazone and the GABA pharmacophores in order to develop a multifunctional drug useful in the treatment of neurological disorders like epilepsy and neuropathic pain. "
2.	Nervous System Diseases (Neurological Disorders) 05/17/2007 - "The present study aims at the design and synthesis of newer gamma-aminobutyric acid (GABA) derivatives with the combination of aryl semicarbazone and the GABA pharmacophores in order to develop a multifunctional drug useful in the treatment of neurological disorders like epilepsy and neuropathic pain. "
3.	Epilepsy (Aura) 05/17/2007 - "The present study aims at the design and synthesis of newer gamma-aminobutyric acid (GABA) derivatives with the combination of aryl semicarbazone and the GABA pharmacophores in order to develop a multifunctional drug useful in the treatment of neurological disorders like epilepsy and neuropathic pain. "
4.	Type 2 Diabetes Mellitus (MODY) 10/01/2022 - "This study identifies thio- and semicarbazones as new classes of DPP-IV inhibitors which may translate into safe and effective therapeutics for a better management of type 2 diabetes.Communicated"
5.	Ulcer 06/01/1991 - "Studies on antipeptic ulcer agents: the quantitative structure-activity relationship analysis of heterocyclic aldehyde N4-substituted phenyl (thio) semicarbazones." 01/01/1989 - "[Studies on antipeptic ulcer agents: the synthesis and QSAR analysis of heterocycle aldehyde N4-substituted phenyl(thio)semicarbazones]." 01/01/1990 - "Studies on antipeptic ulcer agents: a structure-activity relationship analysis of aldehyde semicarbazones and aryl hydrazones." 01/01/1989 - "[Studies on antipeptic ulcer agents: the synthesis and structure-activity relationship analysis of heterocycle aldehyde (thio) semicarbazones and acyl hydrazones]."

Related Drugs and Biologics

1.	Dipeptidyl-Peptidase IV Inhibitors
2.	gamma-Aminobutyric Acid (GABA)
3.	Aldehydes
4.	Thiosemicarbazones
5.	Hydrazones
6.	Hydrazines
7.	Nickel
8.	Iron
9.	Hydrogen Peroxide (Hydroperoxide)
10.	cinnamamide

Related Therapies and Procedures

1.	Therapeutics
2.	Renal Dialysis (Hemodialysis)