|2.||Bovine Spongiform Encephalopathy (Mad Cow Disease)
|4.||Prion Diseases (Transmissible Spongiform Encephalopathies)
|5.||Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease)
|1.||Jeffrey, Martin: 27 articles (01/2014 - 05/2002)|
|2.||Dong, Xiao-Ping: 26 articles (12/2015 - 08/2002)|
|3.||Caughey, Byron: 25 articles (08/2015 - 03/2002)|
|4.||Carp, Richard I: 25 articles (01/2015 - 06/2002)|
|5.||Yokoyama, Takashi: 25 articles (03/2014 - 05/2002)|
|6.||Prusiner, Stanley B: 23 articles (10/2015 - 03/2003)|
|7.||Zhang, Bao-Yun: 21 articles (12/2015 - 08/2002)|
|8.||Kim, Yong-Sun: 21 articles (01/2015 - 09/2004)|
|9.||Baron, Thierry: 19 articles (01/2015 - 02/2003)|
|10.||Beekes, Michael: 19 articles (01/2015 - 11/2003)|
01/01/2006 - "Improved bioassays allowed the transforming principle (TP) to be purified from pneumococci and prions from scrapie-infected hamster brains. "
08/01/2012 - "The diversity of strains of ovine prions within classical scrapie isolates was investigated by transmission studies in wild type mice. "
01/01/2011 - "Unlike other studies, this study utilized a scrapie cell assay to determine infectivity and quantity of infectious prions. "
12/01/2010 - "In the present study, to elucidate the enteric invasion mechanism of prions and to investigate the age-dependent transmission mechanism suggested by epidemiological studies, wild-type and SCID mice were orally administered brain homogenate from scrapie (Tsukuba 1)-infected mice during the suckling and weaning stages, before being analyzed histopathologically. "
03/01/2009 - "This study concludes that all native sheep breeds are poor in scrapie-resistant PrP genotypes and could contract scrapie if exposed to prions."
|2.||Amyloid (Amyloid Fibrils)IBA
01/01/2013 - "We previously reported that PrPres amyloid in scrapie-infected transgenic mice appeared to delay clearance of microinjected brain ISF tracer molecules. "
09/05/2008 - "In the present study we adopted the conversion system from experimental Scrapie in hamster to bovine recPrP and generated amyloid fibrils. "
01/01/2015 - "To gain insight into this unique situation, we used the 263K scrapie hamster model to search for a putative PrP(Sc)-associated factor that contributes to the infectivity of PrP(Sc) amyloid. "
01/01/2014 - "We propose that this method of conversion provides a robust, reproducible and easily accessible model for scrapie-like amyloid formation, allowing the generation of milligram quantities of physiologically stable β-sheet rich oligomers and fibrils. "
04/01/2013 - "In contrast, scrapie-infected Tg44+/+ mice showed blockage of tracer clearance and colocalization of tracer with perivascular PrPres amyloid. "
10/01/2009 - "To establish that PrP(res) infectivity was eliminated, we utilized the Rocky Mountain Laboratory (RML) mouse-adapted scrapie model system for bioassay. "
01/01/2014 - "In this study we examined 7 deviant ovine field cases of scrapie for some typical molecular aspects of PrP(res) found in CH1641‑scrapie, classical scrapie and BSE. "
03/01/2011 - "In the present study, using baculovirus-derived recombinant PrP (Bac-PrP), we demonstrated that Bac-PrP is useful as a PrP(C) substrate for amplification of the mouse scrapie prion strain Chandler, and PrP(Sc) that accumulated in mice inoculated with Bac-PrP(res) had biochemical and pathological properties very similar to those of the PrP(Sc) seed. "
01/01/2009 - "In a recent study, it was shown that sheep intracerebrally inoculated with a US scrapie agent (No. 13-7) developed scrapie and survived for an average of 19 months post inoculation. "
10/01/2004 - "The results from this study seem to confirm that the PrP(res) isolated from the BSE case in Alberta has similar molecular properties to the PrP(res) isolated from a BSE case in the UK, and that it differs in its molecular and immunological characteristics from the CWD and scrapie cases studied."
08/01/2012 - "While vaccine-induced PrP-specific CD4(+) T cells and antibodies partially protect scrapie-infected mice from disease, the potential autoreactivity of CD8(+) cytotoxic T lymphocytes (CTLs) received little attention. "
05/01/2011 - "The most effective results, without any section loss, were obtained with 10 μg/ml PK in phosphate buffered saline containing 0.1% Triton-X at room temperature for 10 min and 150 mM NaOH at 60 °C for 10 min. By this simple procedure, PrP(Sc) was visualized in the brain of animals with BSE and scrapie using a range of anti-PrP primary antibodies."
08/01/2010 - "To this end, we have generated PrP-specific antibodies (known as PrioV) by immunization of camels with murine scrapie material adsorbed to immunomagnetic beads. "
03/01/2008 - "Antibodies directed against PrP(c), when added to scrapie-infected cell cultures or passively administered in vivo, can result in elimination of PrP(sc) or prevent its replication, respectively. "
03/01/2007 - "These antibodies also recognized PrP(Sc) from other scrapie-infected mammals. "
|5.||Sodium Hydroxide (Caustic Soda)FDA Link
06/01/2007 - "This study investigated the efficacy of sodium hydroxide at 0.1M, 0.25M and 0.5M concentrations for the inactivation of mouse-adapted scrapie strain ME7. "
06/01/2007 - "Investigation by bioassay of the efficacy of sodium hydroxide treatment on the inactivation of mouse-adapted scrapie."
05/01/2011 - "To detect PrP(Sc) in animals naturally affected with bovine spongiform encephalopathy (BSE) and scrapie, we applied minimal pretreatment with sodium hydroxide (NaOH). "
03/25/1989 - "Of all the chemical and physical decontamination procedures which are effective against conventional viruses, only high temperature autoclaving, high concentrations of sodium hypochlorite, and possibly molar sodium hydroxide, are useful against the group of unconventional transmissible agents which includes scrapie. "
01/01/1991 - "Such studies suggest that no standard chemical or physical decontamination procedure will reliably inactivate the amount of scrapie/BSE infectivity present in worst-case situations but high concentrations of sodium hypochlorite or sodium hydroxide have been shown respectively to be completely effective or almost so. "
|6.||Proteins (Proteins, Gene)IBA
04/01/2015 - "The current understanding of RidA in Salmonella and the broad distribution of Rid family proteins provide exciting opportunities for future studies to define metabolic roles of Rid family members from microbes to man. "
01/01/2013 - "The objective of the present study was to assess the disease specificity of differentially abundant urine proteins able to identify scrapie infected mice. "
04/01/2015 - "The acetylating forms of Sirt1 target proteins, P53, PGC-1, and STAT3, markedly increased both in the brains of scrapie-infected rodents and in SMB-S15 cells, representing decreased Sirt1 activity. "
01/01/2015 - "RidA proteins belong to the YjgF/YER057c/UK114 family (here renamed the Rid family). "
07/01/2014 - "RidA (for Reactive Intermediate Deaminase A) proteins are ubiquitous, yet their function in eukaryotes is unclear. "
|7.||Protein Isoforms (Isoforms)IBA
11/16/1990 - "Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication."
02/01/1987 - "Our analyses may explain some experimental observations on PrP, and suggest further studies on the properties of the scrapie and cellular PrP isoforms."
01/01/2015 - "Scrapie is diagnosed antemortem in sheep by detecting misfolded isoforms of prion protein (PrP(Sc)) in lymphoid follicles of the rectal mucosa and nictitating membranes. "
11/01/2013 - "To clarify conformational differences between these two isoforms, PrP-deficient mice were immunized with brain homogenates of normal and scrapie-infected animals. "
12/11/2012 - "With the PrP118-135 concentration increasing, the molecular number ratio of parallel β-sheet structure increases and reaches about 44% at a concentration of 0.10 mg/mL, indicating the formation of abnormally folded scrapie isoforms. "
01/01/2009 - "We have also shown that manganese increases infectivity of mouse passaged scrapie to culture cells by 2 logs. "
02/01/2000 - "Analyses of food chains supporting isolated clusters of sporadic TSEs (CWD in N Colorado, scrapie in Iceland, CJD in Slovakia) demonstrate a consistent 2 1/2+ fold greater concentration of the pro-oxidant divalent cation, manganese (Mn), in relation to normal levels recorded in adjoining TSE-free localities. "
06/01/2007 - "Elevated manganese levels in blood and central nervous system occur before onset of clinical signs in scrapie and bovine spongiform encephalopathy."
06/01/2010 - "The aim of this study was to analyse the effects of manganese and copper imbalance on neuronal apoptosis in a scrapie-infected Tga20 mouse model. "
01/01/2010 - "Previous studies indicated that the iron (Fe)/manganese (Mn) ratio in forage of sheep was significantly higher on scrapie-afflicted farms than on farms in other scrapie categories. "
06/01/2008 - "The yield of peptides was significantly greater for BSE than scrapie strains and the relative quantities of particular peptide pairs differed between strains. "
03/01/2010 - "The present study was aimed at investigating whether bone-marrow-derived dendritic cells (DCs) loaded with peptides previously shown to be immunogenic in PrP-deficient mice, can overcome tolerance in PrP-proficient wild-type mice and protect them against scrapie. "
03/01/2004 - "Based on epitope mapping studies with P4 and peptides, it appeared that N-terminal amino acid sequence WGQGGSH was intact only in sheep scrapie digests. "
01/15/2003 - "The present study was carried out to determine whether immunization with the immunogenic PrP peptides might influence the natural history of experimental scrapie in mice. "
02/21/2014 - "Using a highly sensitive protein separation technique and taking advantage of reference maps of synthetic PrP peptides, we investigated brain tissues from scrapie-infected "anchorless PrP" Tg mice and wild type mice to determine the contribution of the GPI-anchor to the molecular mass and isoelectric point of PrP quasispecies under two-dimensional electrophoresis. "
04/01/1992 - "Further analysis of nucleic acids in purified scrapie prion preparations by improved return refocusing gel electrophoresis."
01/01/1986 - "Molecular hybridization studies with scrapie brain nucleic acids. "
01/01/1986 - "Molecular hybridization studies with scrapie brain nucleic acids. "
07/01/1985 - "This study reports the partial characterization of nucleic acids present in gradient fractions enriched for large membrane vesicles from scrapie-infected and uninfected hamster brains. "
07/10/2012 - "It has been shown that nucleic acids catalyze the misfolding of cellular PrP into a scrapie-like conformer. "
01/22/2001 - "Fetal cell grafts provide long-term protection against scrapie induced neuronal loss."
04/01/2001 - "Normal neurogenesis and scrapie pathogenesis in neural grafts lacking the prion protein homologue Doppel."
01/01/1998 - "Scrapie-infected PrPC-expressing grafts develop a severe spongiform encephalopathy and contain proteinase-resistant protein and infectivity. "
01/01/1998 - "As the infected hosts were not clinically affected, we were able to prolong the experiment and to assess changes in the graft over periods of time, which vastly exceeded the normal life span of scrapie-infected mice. "
01/01/1998 - "Identification of the end stage of scrapie using infected neural grafts."
05/01/2002 - "A single treatment of mice with huTNFR:Fc before or shortly after intraperitoneal injection with the ME7 scrapie strain significantly delayed the onset of disease in the CNS and reduced the early accumulation of disease-specific PrP in the spleen. "
01/01/1994 - "The final experiment dealt with the question of scrapie replication in the lymphoreticular organs in mouse strains with different incubation periods for 139A after intraperitoneal injection. "
01/01/1985 - "Injection of mice with thioglycolate 5 days prior to intraperitoneal injection of scrapie brain homogenate led to a statistically significant increase in scrapie incubation periods. "
03/01/1986 - "A single intraperitoneal injection of 250 micrograms dextran sulphate 500 (DS500) reduced the susceptibility of mice to scrapie given by the same route. "
06/01/1983 - "Administration of potent mouse interferon preparations or anti-mouse interferon globulin did not influence the evolution of scrapie in mice after intraperitoneal injection of the agent. "
|3.||Blood Transfusion (Blood Transfusions)
01/01/2013 - "Our studies found that PrP(Sc) accumulation in 82% of animals' abdominal hemal nodes when PrP(Sc) is detected in both mesenteric and retropharyngeal lymph nodes collected from preclinical and clinical, naturally and experimentally (blood transfusion) scrapie-infected sheep representing all three major scrapie-susceptible Prnp genotypes. "
02/01/2012 - "Using two distinct sheep scrapie models and blood transfusion, this work demonstrates the occurrence of a very early and persistent prionemia. "
01/01/2010 - "Pathological phenotype of sheep scrapie after blood transfusion."
12/01/2008 - "We previously reported preliminary data demonstrating the transmission of BSE and natural scrapie by blood transfusion in sheep. "
11/01/2002 - "A model has been developed for the experimental study of TSE transmission by blood transfusion using sheep experimentally infected with bovine spongiform encephalopathy (BSE) or natural scrapie as donors and susceptible scrapie-free sheep as recipients. "
01/01/2008 - "In the present study, we have examined differential gene expression in ileal Peyer's patches and in laser microdissected follicles of sheep infected with scrapie. "
01/01/2008 - "Ileal Peyer's patches and laser microdissected follicles were of scrapie and control lambs with susceptible genotypes for classical scrapie. "
04/01/2000 - "Using two different murine scrapie models, hippocampal pyramidal cells were studied through microinjection of fluorescent dye, and synaptic integrity, using p38-immunoreactivity (p38-IR), both visualized using confocal laser scanning microscopy. "
01/15/1994 - "We report here the detection of DNA damage consistent with apoptosis in the brain cells of sheep infected with scrapie using laser scanning microscopic analysis of the single cell gel assay. "
03/01/1998 - "A competition immunoassay to detect PrPSC from scrapie-infected sheep was developed using free zone capillary electrophoresis with laser-induced fluorescence (LIF) for detection and flourescein-labeled synthetic peptides from PrPSC. "
07/01/2005 - "High incidence of scrapie induced by repeated injections of subinfectious prion doses."
07/03/2001 - "Mice received intra-hippocampal injections of scrapie-infected brain homogenate. "
01/01/1990 - "The reverse sequence of injections (scrapie-0.5 h-drug) had no effect despite the persistence of high scrapie titre in the peritoneum at the time of drug injection. "
01/01/1986 - "injections in the three mouse genotypes, providing an additional parameter that distinguishes these two scrapie strains."
02/10/2005 - "Earlier studies of prion infection following dorsal hippocampal micro-injections of scrapie have shown clear impairments of spatial alternation, but these occurred significantly later than dysfunction in hippocampus-dependent 'domestic' tasks such as nesting or burrowing. "