|1.||Dai, Yue: 5 articles (07/2015 - 08/2010)|
|2.||Boujedaini, Naoual: 4 articles (06/2011 - 07/2009)|
|3.||Paul, Saili: 4 articles (06/2011 - 07/2009)|
|4.||Wei, Zhifeng: 3 articles (07/2015 - 12/2012)|
|5.||Xia, Yufeng: 3 articles (07/2015 - 12/2012)|
|6.||Bhattacharyya, Soumya Sundar: 3 articles (06/2011 - 07/2010)|
|7.||Khuda-Bukhsh, Anisur Rahman: 3 articles (06/2011 - 07/2010)|
|8.||Lee, Mi-Kyung: 2 articles (09/2015 - 04/2014)|
|9.||Lee, Hae-In: 2 articles (09/2015 - 04/2014)|
|10.||Chen, Li: 2 articles (07/2015 - 01/2014)|
09/17/2015 - "Coordinated regulation of scopoletin at adipose tissue-liver axis improved alcohol-induced lipid dysmetabolism and inflammation in rats."
09/17/2015 - "This study investigated the effects of scopoletin on lipid homeostasis and inflammation at the WAT and liver in chronic alcohol-fed rats. "
09/17/2015 - "These results indicated that coordinated regulation of scopoletin at the WAT-liver axis may play an important role in improvement of alcohol-induced lipid dysregulation and inflammation. "
01/01/2012 - "Ameliorative Effects of Scopoletin from Crossostephium chinensis against Inflammation Pain and Its Mechanisms in Mice."
12/01/2012 - "Thus, the results clearly indicated that scopoletin inhibited the monosodium urate crystal-induced inflammation both in vivo and in vitro. "
12/01/2012 - "The present study determined the anti-inflammatory activity of scopoletin in gout air pouch model and revealed the underlying mechanisms by in vitro assays. "
12/01/2012 - "In combination with our previous findings that scopoletin shows hypouricemic, anti-angiogenesis and pro-apoptotic activities, this compound may be a potential agent for gout therapy and could serve as a structural base for developing new drugs."
12/01/2012 - "Monosodium urate (MSU) crystal-induced inflammation in mouse air pouch model, an experimental model for acute gout, was used to assess the efficacy of scopoletin. "
01/01/2013 - "These results suggest that scopoletin is a useful treatment for sugar cataracts. "
01/01/2013 - "Scopoletin's protective effect against sugar cataracts was mediated by inhibiting both AR activity and oxidative stress. "
01/01/2013 - "Administering scopoletin delayed the progression of the cataracts that were induced by dietary galactose. "
01/01/2013 - "To assess scopoletin's ability to mitigate sugar cataract formation in vivo, we studied its effects in a rat model of dietary galactose-induced sugar cataracts. "
07/01/2010 - "Anti-cancer potentials of scopoletin (7-hydroxy-6-methoxy coumarin) separated from plant extract (Gelsemium sempervirens) were demonstrated earlier from our in vitro studies. "
01/01/2009 - "Scopoletin, a bioactive component of noni fruit extract, is measurable in blood and urine following noni ingestion and can be used to study the pharmacokinetics of noni in cancer patients."
07/01/2009 - "Scopoletin, an alkaloid separated from ethanolic extract of the medicinal plant, Gelsemium sempervirens (Fam: Loganiaceae) has been reported to have anti-cancer potentials. "
10/19/2006 - "These results indicate that scopoletin could be a potential antitumoral compound to be used for cancer treatment."
07/01/2015 - "(E)-3-(4-chlorophenyl)-N-(7-hydroxy-6-methoxy-2-oxo-2H-chromen-3-yl) acrylamide (SC-III3), a newly synthesized derivative of scopoletin, was previously shown to reduce the viability of HepG2 cells and tumor growth of HepG2 xenograft mouse model. "
|5.||Hepatocellular Carcinoma (Hepatoma)
07/01/2015 - "SC-III3, a novel scopoletin derivative, induces autophagy of human hepatoma HepG2 cells through AMPK/mTOR signaling pathway by acting on mitochondria."
01/01/2014 - "SC-III3, a novel scopoletin derivative, induces cytotoxicity in hepatocellular cancer cells through oxidative DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation."
03/01/2010 - "In this study the leaves of the Thai noni/Yor, (Morinda citrifolia Linn.) were extracted by several methods and evaluated against human cancer cell lines: KB (human epidermoid carcinoma), HeLa (human cervical carcinoma), MCF-7 (human breast carcinoma) and HepG2 (human hepatocellular carcinoma) cell lines as well as a Vero (African green monkey kidney) cell line, employing the MTT colorimetric method, comparing it to damnacanthal, rutin, and scopoletin. "
08/01/2003 - "Activity-guided fractionation of the EtOAc-soluble extract of the whole plants of Sida acuta using a bioassay based on the induction of quinone reductase (QR) in cultured Hepa 1c1c7 mouse hepatoma cells, led to the isolation of ten active compounds of previously known structure, quindolinone (1), cryptolepinone (2), 11-methoxyquindoline (3), N-trans-feruloyltyramine (4), vomifoliol (5), loliolide (6), 4-ketopinoresinol (7), scopoletin (8), evofolin-A (9), and evofolin-B (10), along with five inactive compounds of known structure, ferulic acid, sinapic acid, syringic acid, (+/-)-syringaresinol, and vanillic acid. "
|1.||Uric Acid (Urate)
|2.||Acetic Acid (Vinegar)
|3.||Interleukin-6 (Interleukin 6)
|1.||Heterologous Transplantation (Xenotransplantation)
|2.||Traditional Medicine (Folk Remedies)
|3.||Chinese Traditional Medicine (Traditional Chinese Medicine)